Expression of GM3 synthase in human atherosclerotic lesions

Activation of ganglioside GM3 biosynthesis in human blood mononuclear cells in atherosclerosis

“…Изменение содержания и состава ганглиозидов в клетках и тканях характерно для ряда патологических процессов, связанных с клеточной трансформацией, миграцией, дифференцировкой и пролиферацией [8]. Ранее мы показали, что содержание основного ганглиозида GM3 в интиме артерий при атеросклерозе резко возрастает по сравнению с непораженной интимой, и установили, что это связано с миграцией моноцитов крови в интиму и их последующей дифференцировкой в макрофаги [20].…”

Suppression of vascular smooth muscle cell responses induced by TNF-α in GM3 synthase gene transfected cells

“…Many studies have demonstrated the ganglioside composition involved in the development and progression of atherosclerosis (23)(24)(25). Studies have shown that GM1 and GM2 induce VSMC proliferation through ERK1/2 activation (31).…”

“…Several studies have shown a dual function of ganglioside GD3, in both cell proliferation and inhibition of cell growth in VSMC (32,33). A number of studies have demonstrated massive and excessive accumulation of GM3 in atherosclerotic lesions (23,24). Other studies reported that exogenously-supplied GM3 inhibited DNA synthesis independently of ERK1/2 activation in VSMC (31).…”

“…Furthermore, the addition of GM3 to the culture medium reduced PDGF-induced signaling pathways in VSMC (25). Although many studies have investigated the effects of ganglioside GM3 in VSMC (23)(24)(25)31), the exact role of GM3 endogenously generated in VSMC remains unclear. In this study, the effects of GM3 synthase gene expression on TNF-· signaling in VSMC were examined.…”

“…Moreover, previous studies showed enhanced insulin sensitivity in animal models lacking the GM3 synthase gene (22). Several studies have shown the accumulation of GM3 in atherosclerotic lesions (23,24). In another study, exogenously-supplied GM3 inhibited VSMC proliferation caused by PDGF (25).…”