2007
DOI: 10.1164/rccm.200607-931oc
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Abstract: Cigarette smoke induces significant changes in oxidant defense responses; some of these are further amplified, but not in a linear fashion, in individuals who develop COPD.

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Cited by 187 publications
(185 citation statements)
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“…In addition to endogenous sources of oxidative stress, cellular systems also have to cope with a variety of exogenous sources of oxidative stress including that imposed by either smoking or exposure to second-hand cigarette smoke. Several other studies have alluded to the importance of cigarette smoke-induced oxidative stress in the pathogenesis of chronic airway inflammation in smokers (Barnes, 2003;Kluchova et al, 2007;Pierrou et al, 2007;Tkacova et al, 2007). Oxidative stress induces CXCL8/IL-8 by macrophages and epithelial cells (Mio et al, 1997;Yang et al, 2006), and has been implicated in the induction of adhesion molecules involved in the recruitment of monocytes and neutrophils to sites of inflammation (Shen et al, 1996).…”
Section: Discussionmentioning
confidence: 99%
“…In addition to endogenous sources of oxidative stress, cellular systems also have to cope with a variety of exogenous sources of oxidative stress including that imposed by either smoking or exposure to second-hand cigarette smoke. Several other studies have alluded to the importance of cigarette smoke-induced oxidative stress in the pathogenesis of chronic airway inflammation in smokers (Barnes, 2003;Kluchova et al, 2007;Pierrou et al, 2007;Tkacova et al, 2007). Oxidative stress induces CXCL8/IL-8 by macrophages and epithelial cells (Mio et al, 1997;Yang et al, 2006), and has been implicated in the induction of adhesion molecules involved in the recruitment of monocytes and neutrophils to sites of inflammation (Shen et al, 1996).…”
Section: Discussionmentioning
confidence: 99%
“…Unfortunately, few studies to date have attempted to address this possibility and no knockout mice for DUOX1/2 are yet available. Analysis of bronchial biopsies from smokers or patients with COPD revealed decreased expression of DUOX1 and ~2-fold upregulation of DUOX2 (207,208), which might be related to characteristic epithelial alterations within these subjects, such as goblet cell hyperplasia and squamous metaplasia (115,209). Analysis of bronchial tissues from patients with severe cystic fibrosis indicated decreased DUOX2 expression (210), thus suppressing a component of host defense leading to enhanced respiratory infections in these subjects.…”
Section: Duoxmentioning
confidence: 96%
“…61,62 In humans, Gpx-1 has been shown to be increased in COPD, 63 and Gpx-2 showed a three-to five-fold up-regulation in epithelial cells of smokers compared with nonsmokers. [64][65][66] Gpx-3 showed a two-fold up-regulation in epithelial cells of smokers compared with nonsmokers. 65,67 There was little evidence of differential regulation of Gpx-4, Gpx-5, or Gpx-7 by disease status.…”
Section: Gpxs In Normal Physiology and Lung Diseasesmentioning
confidence: 91%
“…[64][65][66] Gpx-3 showed a two-fold up-regulation in epithelial cells of smokers compared with nonsmokers. 65,67 There was little evidence of differential regulation of Gpx-4, Gpx-5, or Gpx-7 by disease status. 65 Gpx activity is significantly reduced in smokers and subjects with COPD, highlighting its prominent role in lung antioxidant defense.…”
Section: Gpxs In Normal Physiology and Lung Diseasesmentioning
confidence: 91%