2011
DOI: 10.18632/oncotarget.340
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Abstract: The Facilitates Chromatin Transcription (FACT) chromatin remodeling complex, comprised of two subunits, SSRP1 and SPT16, is involved in transcription, replication and DNA repair. We recently showed that curaxins, small molecules with anti-cancer activity, target FACT and kill tumor cells in a FACT-dependent manner. We also found that FACT is overexpressed in human and mouse tumors and that tumor cells are sensitive to FACT downregulation. To clarify the clinical potential of FACT inhibition, we were interested… Show more

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Cited by 90 publications
(133 citation statements)
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“…Rather, we and others have shown that FACT expression is generally limited to stem-like or undifferentiated cells such as germ cells, stem cells and progenitor cells in mammals and undifferentiated cells in growing parts of plants. [15][16][17] Moreover, Hertel et al demonstrated that protein levels of both FACT subunits decrease during senescence or differentiation of mouse fibroblasts, 18,19 and we found that levels of SSRP1 and, even more dramatically, SPT16, decline upon induction of in vitro differentiation of mouse myoblasts into myotubes. 16 Given the very low or undetectable levels of expression of both FACT subunits in normal adult tissues, FACT has strong potential as a diagnostic/prognostic marker and therapeutic anticancer target, particularly for poorly differentiated, aggressive tumors.…”
Section: Introductionsupporting
confidence: 58%
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“…Rather, we and others have shown that FACT expression is generally limited to stem-like or undifferentiated cells such as germ cells, stem cells and progenitor cells in mammals and undifferentiated cells in growing parts of plants. [15][16][17] Moreover, Hertel et al demonstrated that protein levels of both FACT subunits decrease during senescence or differentiation of mouse fibroblasts, 18,19 and we found that levels of SSRP1 and, even more dramatically, SPT16, decline upon induction of in vitro differentiation of mouse myoblasts into myotubes. 16 Given the very low or undetectable levels of expression of both FACT subunits in normal adult tissues, FACT has strong potential as a diagnostic/prognostic marker and therapeutic anticancer target, particularly for poorly differentiated, aggressive tumors.…”
Section: Introductionsupporting
confidence: 58%
“…[15][16][17] Moreover, Hertel et al demonstrated that protein levels of both FACT subunits decrease during senescence or differentiation of mouse fibroblasts, 18,19 and we found that levels of SSRP1 and, even more dramatically, SPT16, decline upon induction of in vitro differentiation of mouse myoblasts into myotubes. 16 Given the very low or undetectable levels of expression of both FACT subunits in normal adult tissues, FACT has strong potential as a diagnostic/prognostic marker and therapeutic anticancer target, particularly for poorly differentiated, aggressive tumors. 16,14 To facilitate development of strategies for therapeutic modulation of FACT, this study was aimed at characterizing the endogenous mechanisms that control cellular levels of FACT.…”
Section: Introductionsupporting
confidence: 58%
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