Expression of  -Catenin, a Key Mediator of the WNT Signaling Pathway, in Basal Cell Carcinoma

Boonchai, Waranya; Walsh, Michael D.; Cummings, Margaret C.; Chenevix-Trench, Georgia

doi:10.1001/archderm.136.7.937

Cited by 24 publications

(16 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to earlier work by Boonchai et al. , 71 El‐Bahrawy et al . have recently shown that the immunohistological localization of β‐catenin gives a degree of credence to the growth pattern classification of BCC used in the minimum dataset 72 .…”

Section: How Does Molecular Analysis Impact On the Minimum Dataset Focontrasting

confidence: 83%

Basal cell carcinoma: a dermatopathological and molecular biological update

2003

View full text Add to dashboard Cite

The ideal classification of basal cell carcinoma (BCC) should be able to identify subtypes which correlate with clinical behaviour and treatment requirements. Unfortunately, however, such a classification has yet to be defined. In the interim, the currently most favoured classification is one based predominantly on histological growth pattern. This classification contributes to the useful concept of low- and high-risk histological subtypes of BCC. The latter are characterized by an increased probability of subclinical extension and/or incomplete excision and/or aggressive local invasive behaviour and/or local recurrence. The Royal College of Pathologists has published a minimum dataset for the histopathological reporting of BCC and this has been written to be compatible with the British Association of Dermatologists' management guidelines. Growth patterns to be reported include nodular, superficial, infiltrative/morphoeic and micronodular types, together with differentiation when of severely atypical or malignant squamous type (basosquamous carcinoma). Deep and peripheral excision margins will be reported to be either involved or clear. The latter will include a comment of a clearance of less than 1 mm for close margins and a measured distance in whole millimetres for other excisions. Clinical assessment and histology remain the 'gold standard' for evaluating BCC and cancers in general. However, in the postgenomic era emphasis is changing from the gathering and archiving of genomic data to its analysis and use in guiding clinical practice. In this context, a current goal is to define cancer phenotype in terms of molecular abnormalities and use this as a new gold standard. One way to assess whether this goal is being achieved for BCC is to determine whether our knowledge of its molecular pathology has any relevance to the minimum dataset for histological reporting. Knowledge of BCC molecular pathology has been fuelled by the recent discovery that deregulation of the Hedgehog (Hh) signalling pathway, a key player in embryonic patterning, appears to be fundamental to tumour growth. But despite accrual of a large amount of data concerning Hh pathway molecular alterations in neoplasia, little is known about the functional consequences of these changes in BCC, how they lead to tumour development, or how they relate to non-Hh pathway alterations such as TP53 mutation. Recent work suggests that the cellular localization of beta-catenin gives a degree of credence to the growth pattern classification of BCC. Furthermore, it is possible that beta-catenin may have a pathogenetic role in the invasive behaviour of BCC. This review draws on current evidence to discuss these issues and assess whether they are relevant to the minimum dataset.

show abstract

Section: How Does Molecular Analysis Impact On the Minimum Dataset Focontrasting

confidence: 83%

Basal cell carcinoma: a dermatopathological and molecular biological update

2003

View full text Add to dashboard Cite

show abstract

“…While preparing this paper, it was reported that β‐catenin only localizes in the cytoplasm and plasma membrane, but not in the nuclei in BCC 14 . With these observations, the authors concluded that β‐catenin appeared to play a role in BCC as a cell adhesion molecule but is not involved in nuclear signalling.…”

Section: Discussionmentioning

confidence: 88%

“…Although their findings are entirely in contrast with the present observations showing nuclear localization in BCC at higher frequency, we anticipate that this discrepancy may be caused by differences in the methods of immunohistochemical staining. While Boonchai et al 14 . immunostained paraffin‐embedded sections with immunochemical substrates as a colour developer, we examined frozen non‐fixed samples with an immunofluorescence method.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.

et al. 2001

View full text Add to dashboard Cite

show abstract

“…Lack of expression and/or suppressed activation of patched homologue 1 (PTCH1), a tumour suppressor gene that forms part of the hedgehog signaling network [21], has been reported to be fundamental to the development of BCC [22]. Disruption of this tumour suppressor gene results in up-regulated cell proliferation [6].…”

Section: Discussionmentioning

confidence: 99%

Untitled

et al. 2006

View full text Add to dashboard Cite

Background: Skin cancer accounts for 1/3 of all newly diagnosed cancer. Although seldom fatal, basal cell carcinoma (BCC) is associated with severe disfigurement and morbidity. BCC has a unique interest for researchers, as although it is often locally invasive, it rarely metastasises. This paper, reporting the first whole genome expression microarray analysis of skin cancer, aimed to investigate the molecular profile of BCC in comparison to non-cancerous skin biopsies. RNA from BCC and normal skin specimens was analysed using Affymetrix whole genome microarrays. A Welch t-test was applied to data normalised using dCHIP to identify significant differentiallyexpressed genes between BCC and normal specimens. Principal component analysis and support vector machine analysis were performed on resulting genelists, Genmapp was used to identify pathways affected, and GOstat aided identification of areas of gene ontology more highly represented on these lists than would be expected by chance.

show abstract

Expression of -Catenin, a Key Mediator of the WNT Signaling Pathway, in Basal Cell Carcinoma

Cited by 24 publications

References 5 publications

Basal cell carcinoma: a dermatopathological and molecular biological update

Basal cell carcinoma: a dermatopathological and molecular biological update

Immunohistochemical detection for nuclear beta-catenin in sporadic basal cell carcinoma.

Untitled

Contact Info

Product

Resources

About