2012
DOI: 10.1093/gerona/glr225
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Abstract: The level of green fluorescent protein expression from an hsp-16.2-based transcriptional reporter predicts life span and thermotolerance in Caenorhabditis elegans. The initial report used a high-copy number reporter integrated into chromosome IV. There was concern that the life-span prediction power of this reporter was not attributable solely to hsp-16.2 output. Specifically, prediction power could stem from disruption of some critical piece of chromatin on chromosome IV by the gpIs1 insertion, a linked mutat… Show more

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Cited by 43 publications
(46 citation statements)
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“…Others HSPs, mostly the small, monomeric hsp-16 family, are induced by and function during stress [7,1013]. HSP-reporter proteins now serve as rheostats for stress induction [1417]…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Others HSPs, mostly the small, monomeric hsp-16 family, are induced by and function during stress [7,1013]. HSP-reporter proteins now serve as rheostats for stress induction [1417]…”
Section: Introductionmentioning
confidence: 99%
“…The observations that HSPs accumulate in response to various stresses [16] and during aging [3638], that mutations that alter HSP expression influence lifespan [39], and that HSP expression can be predictive of lifespan [17] have led to the model that the perdurance of HSPs (and other proteins) from an initial stress exposure will be protective when an organism is exposed to subsequent insults [4043]. …”
Section: Introductionmentioning
confidence: 99%
“…Subsequent studies, however, were more consistent with substantial heritability of these phenotypes (Cypser et al, 2013). We await more detailed information on subsequent generations of single copy transgenic worms with exceptionally strong or exceptionally weak expression (Mendenhall et al, 2012).…”
Section: The Role Of Chancementioning
confidence: 84%
“…Golden et al have performed microarray analysis of individual wild type and daf-2 hypomorph worms during aging, finding among other things that again heat-shock proteins show significant variation with age [80, 81]. In agreement with these findings, heat shock protein hsp-16.2 expression has been shown to predict individual lifespan in a genetically homogenous population of worms [82, 83]. …”
Section: Whole Genome Expression Profiling Of Aging and Lifespanmentioning
confidence: 85%