2000
DOI: 10.1111/j.1528-1157.2000.tb00133.x
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Abstract: Summary: Purpose:The hippocampus is one of the principal target areas for neurosteroidal action, and the major neuroendocrine conversion of progesterone appears to be Sa-reduction and 301-hydroxysteroid oxidoreduction, leading to the potent neurosteroid 3~~,5~~-tetrahydroxyprogesterone. To investigate whether the human hippocampus is equipped with the enzymes 5a-reductase and 3a-hydroxysteroid oxidoreductase (301-HSOR), we studied the expression of 5a-reductase types 1 and 2 and 3a-HSOR types 1 and 2 in the re… Show more

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Cited by 58 publications
(36 citation statements)
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References 49 publications
(40 reference statements)
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“…Our detection of HSD17B7 mRNA in human CNS is a novel finding. We also detected SRD5A2 transcripts within hippocampus and cerebellum, although a previous study had failed to find it in human hippocampus (Stoffel-Wagner et al 2000), possibly due to a lack of sensitivity in their assay, as our C t results for this gene were high (w35 cycles in hippocampus), signifying low levels of transcription. Given the use of homogenised brain tissue in this study, it was not possible to assess whether gene transcription is solely neuronal or glial, or whether it occurs in both cell types.…”
Section: Discussionmentioning
confidence: 79%
“…Our detection of HSD17B7 mRNA in human CNS is a novel finding. We also detected SRD5A2 transcripts within hippocampus and cerebellum, although a previous study had failed to find it in human hippocampus (Stoffel-Wagner et al 2000), possibly due to a lack of sensitivity in their assay, as our C t results for this gene were high (w35 cycles in hippocampus), signifying low levels of transcription. Given the use of homogenised brain tissue in this study, it was not possible to assess whether gene transcription is solely neuronal or glial, or whether it occurs in both cell types.…”
Section: Discussionmentioning
confidence: 79%
“…The most widely studied are allopregnanolone, THDOC, and androstanediol (Fig.1). There is now compelling evidence that all of the enzymes required for the biosynthesis of the neurosteroids from cholesterol are present in the brain (Stoffel-Wagner et al, 2000; 2003). Allopregnanolone and related neurosteroids are produced via sequential A-ring reduction of the steroid hormones by 5α-reductase and 3α-hydroxysteroid-oxidoreductase isoenzymes (Reddy, 2009a).…”
Section: Neurosteroid Biosynthesis In the Brainmentioning
confidence: 99%
“…of progesterone, are not totally inactive but may have significant biological effects. 3a,5a-Tetrahydro-progesterone (3a,5a-TH-P) and 3a,5b-TH-P are ligands for the gamma-aminobutyric acid A receptor and have anesthetic, anxiolytic and anticonvulsant potency (21)(22)(23)(24). 5b-Dihydro(DH)-P reduces myometrial contractions (25) and shows pyrogenic effects (21).…”
Section: Introductionmentioning
confidence: 99%