Expression and regulation of genes associated with cell death during murine preimplantation embryo development

Nuclear–cytoplasmic incompatibility and inefficient development of pig–mouse cytoplasmic hybrid embryos

“…Apoptosis is regulated by the activity of pro-and anti-apoptotic genes during preimplantation development (Jurisicova et al 1998). Therefore, we also evaluated the expression of anti-apoptotic genes such as Bcl2 and Hspb1 (Jurisicova et al 1998, Exley et al 1999; both the genes were significantly downregulated in cytoplasmic hybrids. Taken together, while the low abundance of Mfn2, glucose transporter genes increased the sensitivity of cytoplasm hybrids to apoptotic stimuli, poor expression of anti-apoptotic genes may have failed to prevent apoptosis.…”

Effects of in vitro fertilization and embryo culture on TRP53 and Bax expression in B6 mouse embryos

“…Embryos produced Trp53 mRNA throughout the preimplantation stage, confirming findings in other strains [12]. TRP53 protein was also expressed at relatively low levels during the normal preimplantation phase development.…”

p53-Dependent S-Phase Damage Checkpoint and Pronuclear Cross Talk in Mouse Zygotes with X-Irradiated Sperm

“…One-cell-stage transcription of the p53 gene is consistent with the previous report (21). Lack of G 1 /S arrest in irradiated-sperm zygotes.…”