Biochemical Pharmacology volume 77, issue 2, P258-268 2009 DOI: 10.1016/j.bcp.2008.10.012 View full text
Justin D. Lutz, Vaishali Dixit, Catherine K. Yeung, Leslie J. Dickmann, Alex Zelter, Jayne E. Thatcher, Wendel L. Nelson, Nina Isoherranen

Abstract: AbstractRetinoic acid (RA) is a critical signaling molecule that performs multiple functions required to maintain cellular viability. It is also used in the treatment of some cancers. Enzymes in the CYP26 family are thought to be responsible for the elimination of RA, and CYP26A1 appears to serve the most critical functions in this family. In spite of its importance, CYP26A1 has neither been heterologously expressed nor been characterized kinetically. We expressed the rCYP26A1 in baculovirus infected insect c…

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