2010
DOI: 10.1590/s1808-86942010000200011
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Expressão dos genes que codificam as proteínas anexina-1 e galectina-1 nos pólipos rinossinusais e sua modulação pelo glicocorticoide

Abstract: Rhi nosinusal polyps physiopathology is not fully understand, despite numerous hypotheses regarding its inflammatory process. Aims: a prospective study regarding the gene expression of proteins: anexin-1 and galectin-1, which has an anti-inflammatory action and is modulated by steroids. Materials and Methods: eleven patients with rhinosinusal polyps suffered a biopsy of their polyps at two moments: in the absence of systemic steroids and during its use. In the two samples we assessed the expression of these ge… Show more

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Cited by 5 publications
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“…Our results showed that 11 studies focused on other effects of systemic corticosteroids. Different inflammatory markers have been reported to be regulated by systemic corticosteroids [ 32 , 35 , 43 , 44 , 48 , 51 , 68 ], and different factors have been addressed to have an impact on the responsiveness to systemic corticosteroids [ 59 , 60 , 62 , 63 , 66 ]. This suggests there is a possibility to determine which patients are fitted for systemic corticosteroids to ensure the beneficial effects of the treatment and avoid the risks of side effects for those unresponsive to systemic corticosteroids [ 61 ].…”
Section: Discussionmentioning
confidence: 99%
“…Our results showed that 11 studies focused on other effects of systemic corticosteroids. Different inflammatory markers have been reported to be regulated by systemic corticosteroids [ 32 , 35 , 43 , 44 , 48 , 51 , 68 ], and different factors have been addressed to have an impact on the responsiveness to systemic corticosteroids [ 59 , 60 , 62 , 63 , 66 ]. This suggests there is a possibility to determine which patients are fitted for systemic corticosteroids to ensure the beneficial effects of the treatment and avoid the risks of side effects for those unresponsive to systemic corticosteroids [ 61 ].…”
Section: Discussionmentioning
confidence: 99%