Exposure to the pesticide DDT and risk of diabetes and hypertension: Systematic review and meta-analysis of prospective studies

Hernández-Mariano, José Ángel; Baltazar-Reyes, Mary Carmen; Salazar-Martínez, Eduardo; Cupul-Uicab, Lea A.

doi:10.1016/j.ijheh.2021.113865

Cited by 24 publications

(20 citation statements)

References 61 publications

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“…In line with our results, previous studies reported that pesticide exposure was associated with hypertension ( 20 – 24 ). For example, Samsuddin et al reported an association of chronic exposure to mosquito control-related pesticides with the increase in brachial and aortic BP in workers ( 25 ).…”

Section: Discussionsupporting

confidence: 93%

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Associations Between Household Pesticide Exposure, Smoking and Hypertension

Chen

Liang

Chen

et al. 2022

Front. Public Health

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This analysis aims to investigate the association between household pesticide exposure and hypertension risk, and to determine whether smoking plays a role in this association. We used data from the National Health and Nutrition Examination Survey (NHANES) for the years 1999–2014, including a total of 32,309 U.S. adult participants who were 20 years or older. Smoking status and pesticide exposure were self-reported. Blood pressure was measured by trained personnel using a mercury sphygmomanometer, according to a standardized protocol. We observed an increased risk of hypertension (OR [odds ratio] = 1.10, 95% confidence intervals [CI]: 1.01–1.18) in participants with exposure to household pesticides. Moreover, a significant interaction between smoking status and pesticide exposure on hypertension was observed (P = 0.022). Stratified analysis showed that household pesticide exposure was associated with a 29% higher risk of hypertension (OR = 1.29, 95% CI: 1.08–1.53) in smokers. However, for non-smokers, this association was not significant. Similar trends were found for systolic and diastolic blood pressures. In addition, we investigated the associations between pesticide metabolites in urine/serum and hypertension and found that several metabolites of dioxins, furans, and coplanar polychlorinated biphenyls were significantly associated with a higher risk of hypertension. This study suggests that household pesticide exposure is associated with an elevated risk of hypertension. We also report that smoking may accentuate the effect of pesticide exposure on hypertension.

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Section: Discussionsupporting

confidence: 93%

“…Previous studies reported that organophosphorus were positively associated with hypertension in humans ( 20 , 26 ). Additionally, Bataillard et al reported that low doses of organophosphorus, mainly including paraoxon and soman, provoked marked and durable hypertension in conscious unrestrained rats ( 29 ).…”

Section: Discussionmentioning

confidence: 91%

Associations Between Household Pesticide Exposure, Smoking and Hypertension

Chen

Liang

Chen

et al. 2022

Front. Public Health

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“…During pregnancy, POPs exposure increases the risk of several outcomes such as miscarriage, preterm birth and low birthweight 12–14 . However, findings related to gestational diabetes mellitus (GDM) tend to show more discrepancies 12,15,16 . Zhang et al 17 .…”

Section: Introductionmentioning

confidence: 99%

“…[12][13][14] However, findings related to gestational diabetes mellitus (GDM) tend to show more discrepancies. 12,15,16 Zhang et al 17 describe a positive association between PCB 52 and GDM, and no association for PCB 138, 153 and 180. However, Jaack et al's 18 cohort study shows a negative association between PCB 138, 15, and 180 with GDM.…”

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confidence: 99%

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Persistent organic pollutant exposure as a risk factor of gestational diabetes mellitus: A systematic review and meta‐analysis

Kouiti,

Castillo‐Hermoso,

Youlyouz‐Marfak

et al. 2023

BJOG

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BackgroundFindings related to the association between persistent organic pollutants (POPs) and gestational diabetes mellitus (GDM) are inconclusive.ObjectivesTo estimate the strength of the association between POP exposure and GDM in a systematic review with meta‐analysis.Search strategyMEDLINE, Scopus and Web of Science were searched until July 2023.Selection criteriaCohort and case–control studies analysing the association between POPs and GDM.Data collection and analysisWe assessed the risk of bias using the Quality in Prognosis Studies scale (QUIPS). Standardised mean differences were pooled using random‐effect models.Main resultsSixteen articles including 12 216 participants were selected. The risk of bias was high in four articles (25%), moderate in 11 (68.75%) and low in one (6.25%). Small mean difference between GDM cases and controls was observed for PFHpA (0.26, 95% confidence interval [CI] 0.1–0.35, I2 = 0.0%), PCB180 (0.37, 95% CI 0.19–0.56; I2 = 25.3%), BDE47 (0.23, 95% CI 0.0–0.45, I2 = 0%), BDE99 (0.36, 95% CI 0.14–0.59; I2 = 0%), BDE100 (0.42, 95% CI 0.19–0.64; I2 = 0%) and HCB (0.22, 95% CI 0.01–0.42, I2 = 39.6%). No considerable difference was observed for the rest of POPs.ConclusionSmall mean differences between GDM cases and controls were observed for some POPs. However, evidence shows mostly moderate quality and results were heterogeneous. Improved research methodology is needed to assess POPs and GDM risk.

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