Exposure to parabens and dysglycemia: Insights from a Chinese population

Song, Yu; Wang, Mian; Nie, Luting; Liao, Wei; Wei, Dandan; Wang, Lulu; Wang, Juan; Xu, Qingqing; Huan, Changsheng; Jia, Zexin; Mao, Zhenxing; Wang, Chongjian; Huo, Wenqian

doi:10.1016/j.chemosphere.2023.139868

Cited by 2 publications

(1 citation statement)

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“…MeP also emerged as the most prevalent component of PBs, demonstrating the highest detection rate in the blood across various countries and regions. MeP levels in our study (median: 6.32 ng/mL) slightly exceeded those in adults in the United States, the Czech Republic, and other regions of China (range: 0.28–3.08 ng/mL). ,− Disparities in blood MeP levels primarily resulted from variations in paraben exposure among different genders, age groups, and the usage patterns of diverse hygiene and care products. Similarly, data from the NHANES and the Korean Cohort Exposure Study indicated elevated urine levels of MeP in older adults, attributable to their more frequent use of personal care products. , …”

Section: Discussionmentioning

confidence: 53%

Human Biomonitoring of Environmental Chemicals among Elderly in Wuhan, China: Prioritizing Risks Using EPA’s ToxCast Database

Wang,

Huang

et al. 2024

Environ. Sci. Technol.

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In line with the "healthy aging" principle, we aim to assess the exposure map and health risks of environmental chemicals in the elderly. Blood samples from 918 elderly individuals in Wuhan, China, were analyzed using the combined gas/liquid-mass spectrometry technology to detect levels of 118 environmental chemicals. Cluster analysis identified exposure profiles, while risk indexes and bioanalytical equivalence percentages were calculated using EPA's ToxCast database. The detection rates for 87 compounds exceeded 70%. DEHP, DiBP, naphthalene, phenanthrene, DnBP, pyrene, anthracene, permethrin, fluoranthene, and PFOS showed the highest concentrations. Fat-soluble pollutants varied across lifestyles. In cluster 2, which was characterized by higher concentrations of fat-soluble substances, the proportion of smokers or drinkers was higher than that of nonsmokers or nondrinkers. Pesticides emerged as the most active environmental chemicals in peroxisome proliferator-activated receptor gamma antagonist, thyroid hormone receptor (TR) antagonist, TR agonist, and androgen receptor (AR) agonist activity assays. Additionally, PAEs and polycyclic aromatic hydrocarbons played significant roles as active contaminants for the corresponding targets of AR antagonists and estrogen receptor alpha. We proposed a list of priority pollutants linked to endocrinedisrupting toxic effects in the elderly, which may provide the groundwork for further research into environmental etiology.

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