Exposure to artificial light at night: A common link for obesity and cancer?

Colao, Annamaria; Alviggi, Carlo; Barazzoni, Rocco; Barrea, Luigi; Béguinot, Francesco; Belfiore, A.; Bellastella, Giuseppe; Bettini, Silvia; Bifulco, Giuseppe; Bifulco, Maurizio; Brasacchio, Caterina; Bottiglieri, Filomena; Busetto, Luca; Capaldo, Brunella; Caprio, Massimiliano; Casanueva, Felipe F.; Luigi, Luigi Di; Nisio, Andrea Di; Renzo, Laura Di; Somma, C. Di; Donini, Lorenzo M.; Esposito, Katherine; Federici, Massimo; Garifalos, Francesco; Giugliano, Dario; Gnessi, Lucio; Cappellari, Gianluca G.; Guida, Brunella; Guzzardi, Maria Angela; Laudisio, Daniela; Lenzi, Andrea; Liccardi, Alessia; Lubrano, Carla; Macchia, Paolo; Magno, Silvia; Marzullo, Paolo; Menafra, Davide; Migliaccio, Silvia; F, Muratori; Muscogiuri, Giovanna; Napoli, Raffaele; Pelosini, Caterina; Pivari, Francesca; Pivonello, Rosario; Poggiogalle, Eleonora; Pugliese, Gabriella; Riccardi, Gabriele; Ritieni, Alberto; Romano, Fiammetta; Salvatore, Domenico; Sanduzzi, Alessandro; Santini, Ferruccio; Savastano, Silvia; Sbraccia, Paolo; Soldati, Giovanni S.L.; Spera, Giovanni; Tarsitano, Maria G.; Tuccinardi, Dario; Vaccaro, Olga; Venneri, Mary Anna; Sukkar, Samir Giuseppe; Vettor, Roberto

doi:10.1016/j.ejca.2022.06.007

Cited by 32 publications

(16 citation statements)

References 81 publications

(78 reference statements)

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“…The mismatch between the endogenous circadian rhythm and the light environment produced by modern light profiles causes circadian rhythm disturbances in individuals, potentially leading to acute and chronic negative health effects [21][22][23]. In fact, the harmful health effects of artificial light exposure at night have been discussed in several papers [24][25][26].…”

Section: Neuroarchitecture From the Perspective Of Circadian Rhythm A...mentioning

confidence: 99%

“…The influence of artificial light exposure at night on physical health has also been studied. Some studies propose an increase in the incidence of breast cancer, and associations with obesity, hyperlipidemia, and hypertension risk have been suggested [24,34,35]. However, since nighttime artificial light exposure itself cannot act as a direct toxicity factor for cancer, obesity, or hypertension, these associations are thought to be effects determined by critical mediating factors.…”

Section: Neuroarchitecture From the Perspective Of Circadian Rhythm A...mentioning

confidence: 99%

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Neuroarchitecture From the Perspective of Circadian Rhythm, Physical, and Mental Health

Kim¹,

Youn²,

Nam

et al. 2023

Chronobiol Med

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The field of neuroarchitecture explores how various architectural elements impact human physical and mental health, based on neuroscience principles. With the development of functional neuroimaging and electroencephalogram studies, researchers can now visualize and quantify how different architectural factors affect brain activity, emotions, and cognition. Mobile Brain/Body Imaging is a new research methodology that records a moving person’s brain activity and bodily sensations in real time, promising to be a useful tool for space and urban design. In this article, we discuss neuroarchitecture from the perspective of circadian rhythm, physical health, and mental health. Studies have shown that artificial light at night disrupts the circadian rhythm, leading to acute and chronic negative health effects. Conversely, creating a personcentered light environment or incorporating nature-like elements can have a positive impact on health. Research has also shown that exposure to nature reduces self-rumination and contributes to psychological well-being. Neuroarchitecture studies on other factors, such as ceiling height, wall colors, and the movement of people in the building, should be expanded to gain greater insights and practical applications. The convergence of neuroscience and architecture has the potential to identify architectural elements that benefit human physical and mental health.

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Section: Neuroarchitecture From the Perspective Of Circadian Rhythm A...mentioning

confidence: 99%

Section: Neuroarchitecture From the Perspective Of Circadian Rhythm A...mentioning

confidence: 99%

Neuroarchitecture From the Perspective of Circadian Rhythm, Physical, and Mental Health

Kim¹,

Youn²,

Nam

et al. 2023

Chronobiol Med

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show abstract

“…Moreover, a study on mice showed that when kept in constant light exposure, they increase body mass and reduce glucose metabolism [ 74 , 75 ]. In addition, outdoor ALAN exposure has been suggested as a risk factor for breast cancer incidence ( p < 0.01) [ 76 ], ALAN intensity and breast cancer rate ( p < 0.05) [ 77 ] and ALAN and prostate cancer incidence ( p = 0.0369) [ 78 ], while evidence is scarce for indoor light intensity at night [ 79 ]. On the other hand, in a systematic review and meta-analysis that assessed associations between ALAN exposure and breast cancer risk, it was shown that outdoor ALAN exposure was associated with a 12% increase in breast cancer risk, while indoor exposure was associated with a 13% increase, therefore producing similar effects.…”

Section: Impact Of Sleeping Disturbances On Nafld Riskmentioning

confidence: 99%

Role of Circadian Clock on the Pathogenesis and Lifestyle Management in Non-Alcoholic Fatty Liver Disease

et al. 2022

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Several features of the modern lifestyle, such as weekly schedules or irregular daily eating patterns, have become major drivers of global health problems, including non-alcoholic fatty liver disease (NAFLD). Sleep is an essential component of human well-being, and it has been observed that when circadian rhythms are disrupted, or when sleep quality decreases, an individual’s overall health may worsen. In addition, the discrepancy between the circadian and social clock, due to weekly work/study schedules, is called social jetlag and has also been associated with adverse metabolic profiles. Current management of NAFLD is based on dietary intake and physical activity, with circadian preferences and other environmental factors also needing to be taken into account. In this regard, dietary approaches based on chrononutrition, such as intermittent fasting or time-restricted feeding, have proven to be useful in realigning lifestyle behaviors with circadian biological rhythms. However, more studies are needed to apply these dietary strategies in the treatment of these patients. In this review, we focus on the impact of circadian rhythms and the role of sleep patterns on the pathogenesis and development of NAFLD, as well as the consideration of chrononutrition for the precision nutrition management of patients with NAFLD.

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“…On the one hand, the widespread application of ALAN has brought tremendous social benefits [ 14 ], profoundly altering our lifestyles and greatly enhancing the night sky’s luminosity [ 15 ]. On the other hand, ALAN has also significantly disrupted natural light patterns and has progressively been recognized as a new source of pollution that contributes to human health hazards, such as circadian rhythm disorder, breast cancer, and obesity [ 16 , 17 ]. Current research has focused on the association between ALAN and obesity and metabolic disorders in adults [ 18 , 19 , 20 ], especially shift workers exposed to higher levels of ALAN, but little is known for children and adolescents [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Artificial Light-at-Night Exposure and Overweight and Obesity across GDP Levels among Chinese Children and Adolescents

Dang

Shi

et al. 2023

Nutrients

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Background: Evidence in adults suggests that exposure to artificial light-at-night (ALAN) leads to obesity. However, little is known about whether this effect exists in children and adolescents. We aimed to investigate whether ALAN exposure was associated with overweight and obesity in school-aged children and adolescents and whether this association varied with socioeconomic status. Methods: Data on the height and weight of 129,500 children and adolescents aged 10–18 years from 72 cities were extracted from the 2014 Chinese National Survey on Students’ Constitution and Health (CNSSCH). The ALAN area percentage and average ALAN intensity were calculated using the Visible/Infrared Imager/Radiometer Suite. The subjects were separated into three categories based on the cities’ gross domestic product per capita (GDPPC). A mixed-effect logistic regression model and generalized additive model (GAM) were utilized to evaluate the association between ALAN exposure and overweight and obesity in children and adolescents stratified by municipal GDPPC. Results: Both ALAN area (OR = 1.194, 95% CI: 1.175–1.212) and ALAN intensity (OR = 1.019, 95% CI: 1.017–1.020) were positively associated with overweight and obesity in children and adolescents, and the associations remained robust after adjusting for covariates. ORs for overweight and obesity and ALAN area decreased as GDPPC level increased (first tertile: OR = 1.457, 95% CI: 1.335–1.590; second tertile: OR = 1.350, 95% CI: 1.245–1.464; third tertile: OR = 1.100, 95% CI: 1.081–1.119). Similar results were observed for ALAN intensity. In the GAM models, thresholds existed in almost all these spline trends, indicating that ALAN might have a nonlinear association with overweight and obesity. Conclusions: ALAN contributed to the development of overweight and obesity in children and adolescents and this effect differed with GDPPC. Future longitudinal studies should confirm the causal relationship between ALAN and obesity. Moreover, reducing unnecessary exposure to artificial light at night may have beneficial implications for controlling childhood and adolescent obesity, particularly in low-income areas.

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Exposure to artificial light at night: A common link for obesity and cancer?

Cited by 32 publications

References 81 publications

Neuroarchitecture From the Perspective of Circadian Rhythm, Physical, and Mental Health

Neuroarchitecture From the Perspective of Circadian Rhythm, Physical, and Mental Health

Role of Circadian Clock on the Pathogenesis and Lifestyle Management in Non-Alcoholic Fatty Liver Disease

Artificial Light-at-Night Exposure and Overweight and Obesity across GDP Levels among Chinese Children and Adolescents

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