Exposure to antibiotics during pregnancy alters offspring outcomes

Qu, Wenhao; Liu, Linsheng; Miao, Liyan

doi:10.1080/17425255.2021.1974000

Cited by 10 publications

(7 citation statements)

References 112 publications

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“…It is increasingly recognised that infantile and pregnancy exposure to diversity in the microbiota is important for development of immune responses 36 and that diet is key to maintaining those through life. 37 This might explain why children exposed in utero to antibiotics develop more atopy.…”

Section: Discussionmentioning

confidence: 99%

Maternal mental illness and child atopy: a UK population-based, primary care cohort study

Osam¹,

Hope²,

Ashcroft³

et al. 2023

Br J Gen Pract

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Background: The number of children with maternal mental illness (MMI) is rapidly increasing and less is known about the effects of maternal mental illness on childhood atopy. Aim: To investigate the association between MMI and risk of atopy among offspring. Design and setting: Retrospective cohort study in a UK primary care database (674 general practices). Methods: 590,778 children (born 1st January 1993-30th November 2017) followed until their 18th birthday, linked to their hospital records. We captured time-varying exposure to common (depression, anxiety) serious (psychosis) addiction (alcohol and substance misuse) and other (eating, personality disorder) MMI from six months before pregnancy. Using Cox regression models, we calculated and compared incidence rates of atopy of exposed and unexposed children in primary (asthma, eczema, allergic rhinitis and food allergies) and secondary (asthma, food allergies) care, adjusted for maternal (age, atopy history, smoking, antibiotic use), child (sex, ethnicity, birth year/season) and area covariates (deprivation, region). Results: Children exposed to common MMI were at highest risk of developing asthma and allergic rhinitis (aHR: 1.17, 95%CI=1.13-1.21) and a hospitalisation for asthma (aHR 1.29, 95%CI1.20-1.38). Children exposed to addiction disorders were 9% less likely to develop eczema (aHR: 0.91, 95%CI=0.85-0.97) and 35% less likely to develop food allergies (aHR 0.65, 95%CI=0.45-0.93). Conclusions: The finding that risk of atopy varies by type of MMI prompts important aetiological questions. The link between common mental illness and childhood atopy requires general practitioners and policies makers to act and support vulnerable women to access preventive (e.g. smoking cessation) services earlier.

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Section: Discussionmentioning

confidence: 99%

Maternal mental illness and child atopy: a UK population-based, primary care cohort study

Osam¹,

Hope²,

Ashcroft³

et al. 2023

Br J Gen Pract

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“…Low-dose exposure to antibiotics in the early stages of life can have potential adverse effects on fetal health, so it is crucial to determine fetal exposure to antibiotics in uterus. 97 Most studies have assessed fetal antibiotic exposure through questionnaire surveys or prescriptions in medical records. In Canada, 50% of infants undergo intrapartum antibiotic prophylaxis, among which approximately 30% is used to prevent Group B Streptococcus, and the remainder due to antibiotic coverage used for Caesarean birth.…”

Section: Factors Influencing Exposure Levels Of Antibiotics In Pregnantmentioning

confidence: 99%

“…At critical stages of embryonic and fetal development, it is prone to be vulnerable to environmental pollutants. Low-dose exposure to antibiotics in the early stages of life can have potential adverse effects on fetal health, so it is crucial to determine fetal exposure to antibiotics in uterus . Most studies have assessed fetal antibiotic exposure through questionnaire surveys or prescriptions in medical records.…”

Section: Antibiotics In Pregnant Women and Fetusesmentioning

confidence: 99%

Maternal–Fetal Exposure to Antibiotics: Levels, Mother-to-Child Transmission, and Potential Health Risks

Miao,

Yin,

Liu

et al. 2024

Environ. Sci. Technol.

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Due to its widespread applications in various fields, antibiotics are continuously released into the environment and ultimately enter the human body through diverse routes. Meanwhile, the unreasonable use of antibiotics can also lead to a series of adverse outcomes. Pregnant women and developing fetuses are more susceptible to the influence of external chemicals than adults. The evaluation of antibiotic exposure levels through questionnaire surveys or prescriptions in medical records and biomonitoringbased data shows that antibiotics are frequently prescribed and used by pregnant women around the world. Antibiotics may be transmitted from mothers to their offspring through different pathways, which then adversely affect the health of offspring. However, there has been no comprehensive review on antibiotic exposure and mother-to-child transmission in pregnant women so far. Herein, we summarized the exposure levels of antibiotics in pregnant women and fetuses, the exposure routes of antibiotics to pregnant women, and related influencing factors. In addition, we scrutinized the potential mechanisms and factors influencing the transfer of antibiotics from mother to fetus through placental transmission, and explored the adverse effects of maternal antibiotic exposure on fetal growth and development, neonatal gut microbiota, and subsequent childhood health. Given the widespread use of antibiotics and the health threats posed by their exposure, it is necessary to comprehensively track antibiotics in pregnant women and fetuses in the future, and more in-depth biological studies are needed to reveal and verify the mechanisms of mother-to-child transmission, which is crucial for accurately quantifying and evaluating fetal health status.

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“…Disruption of immunity might lead to allergic diseases, metabolic disorders, and infection in the fetus. 69 A reversible germ-free colonization system was established to decipher the potential role of maternal microbes during pregnancy. 70 With this system, transiently colonizing pregnant female mice with a live nonreplicating E. coli HA107 modulates the intestinal mucosal innate immune composition by increasing intestinal group 3 innate lymphoid cells and F4/80 + CD11c + mononuclear cells in their pups.…”

Section: Maternal Microbiome and Fetal Health And Development During ...mentioning

confidence: 99%

Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation

Tian

Zheng

et al. 2023

Gut Microbes

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The maternal microbiome is essential for the healthy growth and development of offspring and has long-term effects later in life. Recent advances indicate that the maternal microbiome begins to regulate fetal health and development during pregnancy. Furthermore, the maternal microbiome continues to affect early microbial colonization via birth and breastfeeding. Compelling evidence indicates that the maternal microbiome is involved in the regulation of immune and brain development and affects the risk of related diseases. Modulating offspring development by maternal diet and probiotic intervention during pregnancy and breastfeeding could be a promising therapy in the future. In this review, we summarize and discuss the current understanding of maternal microbiota development, perinatal microbial metabolite transfer, mother-to-infant microbial transmission during/after birth and its association with immune and brain development as well as corresponding diseases.

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Exposure to antibiotics during pregnancy alters offspring outcomes

Cited by 10 publications

References 112 publications

Maternal mental illness and child atopy: a UK population-based, primary care cohort study

Maternal mental illness and child atopy: a UK population-based, primary care cohort study

Maternal–Fetal Exposure to Antibiotics: Levels, Mother-to-Child Transmission, and Potential Health Risks

Maternal microbe-specific modulation of the offspring microbiome and development during pregnancy and lactation

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