Exposure to a 900 MHz electromagnetic field for 1 hour a day over 30 days does change the histopathology and biochemistry of the rat testis

Odacı, Ersan; Özyılmaz, Cansu

doi:10.3109/09553002.2015.1031850

Cited by 44 publications

(18 citation statements)

References 43 publications

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“…Meo et al [ 23 ] reported that exposure to mobile phone radiation for 60 min/day for up to 3 months significantly reduced serum testosterone levels. More recently, Odacı and Özyılmaz [ 24 ] showed that exposure to a 900 MHz electromagnetic field for 1 h/day over 30 days caused bad outcomes in adult rat testicular morphology and biochemistry. In human studies, an obvious decrease in sperm motility in semen samples exposed to a 900 MHz cell phone for 5 min was observed among men [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Aqueous Extract fromMorinda officinalis F. C. Howon Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats

Song

Wang²,

Wang

2015

Evidence-Based Complementary and Alternative Medicine

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The present study aimed to assess the protective effects of aqueous extract from Morinda officinalis F. C. How on microwave-induced reproductive impairment in male rats. Microwave exposure injury was induced by exposure of 900 MHz microwaves at 218 μm/cm2radiation densities, 24 hours/day for 10 days. Male Sprague-Dawley rats were randomized to: normal control, microwave exposure model, or water layer or ethyl acetate layer of aqueous extract 40 g/kg treatment groups. After 2 weeks of treatment, sexual performance, serum levels of gonadotrophin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) or testosterone, morphological analysis of testis and epididymis, and GnRH protein expression in the hypothalamus were measured. Pretreatment with water layer of aqueous extract 40 g/kg significantly improved sexual performance, increased serum testosterone level, and decreased LH and GnRH level compared with microwave exposed model rats (all P < 0.05). Water layer of aqueous extract treatment significantly increased seminiferous cell or sperm number in testis and epididymis. Protein expression of GnRH in the hypothalamus significantly decreased in the water layer of aqueous extract treated group (P < 0.05). Ethyl acetate layer of aqueous extract did not show obvious effects on the measured parameters. These findings suggest that water layer of aqueous extract 40 g/kg ameliorates microwave-reduced reproductive impairment.

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Section: Discussionmentioning

confidence: 99%

Effect of Aqueous Extract fromMorinda officinalis F. C. Howon Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats

Song

Wang²,

Wang

2015

Evidence-Based Complementary and Alternative Medicine

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“…Contrary to the afore mentioned findings, some researchers have asserted that being subject to the non-ionizing radiation emitted by cellular phones has no undesired impacts on the testes and other biological tissues [17][18][19]. The contradictory reports on the effects on testes tissue exposed to non-ionizing radiation emitted from cellular phones determined in previous studies, along with the rapid increase of cellular phone usage, encouraged us to carry out this study.…”

Section: Introductionmentioning

confidence: 87%

“…Rago et al [36] reported a statistically significant relationship between the SAR and oxidative DNA damage biomarker 8-OHdG and DNA fragmentation, after exposure to RF-EMR. Even though there are many similar studies in the literature which report the harmful impacts of cellular phones on reproductive functions, there are also studies which report no impacts on testicles functions [17,37,38]. It is known that degenerative effects such as DNA damage and oxidative stress which may be due to RFR depend on the type of cell and experiment setting (exposure time, frequency, SAR, continuous wave, pulsed wave, being exposed as a cellular phone owner etc.)…”

Section: Analysis Of Tas Tos Osi 8-ohdg and Mdamentioning

confidence: 99%

Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones

Alkış

Akdağ

Daşdağ

et al. 2019

Biotechnology & Biotechnological Equipment

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The testes are a sensitive organ to electromagnetic pollution and people are concerned about the harmful effects of the radiofrequency radiation (RFR) emitted from cellular phones. Therefore, the purpose of this study was to investigate the effects of long-term exposure to different RFR frequencies on single-strand DNA breaks and oxidative changes in rat testicular tissue. Twenty-eight male Sprague-Dawley rats were divided randomly into four groups. Three groups were exposed to radiation emitted from 900, 1800 and 2100 MHz RF generators, 2 h/day for 6 months. The sham-control group was kept under the same experimental conditions but the RFR generator was turned off. Immediately after the last exposure, testes were removed and DNA damage, 8-hydroxydeoxyguanosine (8-OHdG), malondialdehyde (MDA), total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI) were analyzed. The results of this study indicated that RFR increased TOS, OSI, MDA and 8-OHdG (p < 0.05). TAS levels in the exposed group were lower than in the sham group (p < 0.05). In terms of DNA damage, the tail intensities in the comet assay were higher in the exposure groups (p < 0.05). This study demonstrated that long-term exposure to RFR emitted by cellular phones may cause oxidative stress and oxidative DNA damage in rat testicular tissue and may generate DNA single-strand breaks at high frequencies (1800 and 2100 MHz). Our results showed that some RFR emitted from cellular phones has potential to lead to cell damage in the testes.

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“…Cincludes that 900 MHz could alter histology, the oxidative status and apoptosis induction in testes. Odaci and Ozyilmaz 2016 [ 22 ] Human spermatozoa (in vitro), n = 26 850 MHz continuous for 1 h; SAR 1.46 W/kg In group 1 of normal sperm, the gene and protein expression of clusterin and DNA fragmentation were increased significantly in EMF exposed sperm. Concluded detrimental effect of mobile phone on sperm parameters.…”

Section: Introduction: History and Sources Of Microwavesmentioning

confidence: 99%

Radiations and male fertility

Kesari

Agarwal

Henkel

2018

Reprod Biol Endocrinol

176

102

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During recent years, an increasing percentage of male infertility has to be attributed to an array of environmental, health and lifestyle factors. Male infertility is likely to be affected by the intense exposure to heat and extreme exposure to pesticides, radiations, radioactivity and other hazardous substances. We are surrounded by several types of ionizing and non-ionizing radiations and both have recognized causative effects on spermatogenesis. Since it is impossible to cover all types of radiation sources and their biological effects under a single title, this review is focusing on radiation deriving from cell phones, laptops, Wi-Fi and microwave ovens, as these are the most common sources of non-ionizing radiations, which may contribute to the cause of infertility by exploring the effect of exposure to radiofrequency radiations on the male fertility pattern. From currently available studies it is clear that radiofrequency electromagnetic fields (RF-EMF) have deleterious effects on sperm parameters (like sperm count, morphology, motility), affects the role of kinases in cellular metabolism and the endocrine system, and produces genotoxicity, genomic instability and oxidative stress. This is followed with protective measures for these radiations and future recommendations. The study concludes that the RF-EMF may induce oxidative stress with an increased level of reactive oxygen species, which may lead to infertility. This has been concluded based on available evidences from in vitro and in vivo studies suggesting that RF-EMF exposure negatively affects sperm quality.

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Exposure to a 900 MHz electromagnetic field for 1 hour a day over 30 days does change the histopathology and biochemistry of the rat testis

Abstract: The results show that exposure to 900 MHz EMF causes alterations in adult rat testicular morphology and biochemistry.

Cited by 44 publications

References 43 publications

Effect of Aqueous Extract fromMorinda officinalis F. C. Howon Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats

Effect of Aqueous Extract fromMorinda officinalis F. C. Howon Microwave-Induced Hypothalamic-Pituitary-Testis Axis Impairment in Male Sprague-Dawley Rats

Single-strand DNA breaks and oxidative changes in rat testes exposed to radiofrequency radiation emitted from cellular phones

Radiations and male fertility

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