Exploring the Role of Serology Testing to Strengthen Vaccination Initiatives and Policies for COVID-19 in Asia Pacific Countries and Territories: A Discussion Paper

Chotpitayasunondh, Tawee; Fisher, Dale; Hsueh, Po-Ren; Lee, Ping–Ing; Crespo, Katya Nogales; Ruxrungtham, Kiat

doi:10.3390/ijtm2030024

Cited by 2 publications

(2 citation statements)

References 180 publications

(252 reference statements)

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“…Healthcare workers proved to be an ideal population in which to study the hybrid immune response, as they are continuously exposed to virus variants and are vaccinated in accordance with vaccination scheme programs that are performed at adequate and standardized times [ 16 ]. Recently, different serology tests have become available to identify neutralizing SARS-CoV-2-specific antibodies [ 17 ]. Thus, the literature shows significant variability in the titers of antibodies against the anti-SARS-CoV-2 anti-nucleocapsid (N), anti-receptor-binding domain (RBD), and the anti-SARS-CoV-2 spike protein S1 and S2 subunit [ 11 , 14 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

A Serological Analysis of the Humoral Immune Responses of Anti-RBD IgG, Anti-S1 IgG, and Anti-S2 IgG Levels Correlated to Anti-N IgG Positivity and Negativity in Sicilian Healthcare Workers (HCWs) with Third Doses of the mRNA-Based SARS-CoV-2 Vaccine: A Retrospective Cohort Study

Serra,

Andriolo,

Butera

et al. 2023

Vaccines

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Background: With SARS-CoV-2 antibody tests on the market, healthcare providers must be confident that they can use the results to provide actionable information to understand the characteristics and dynamics of the humoral response and antibodies (abs) in SARS-CoV-2-vaccinated patients. In this way, the study of the antibody responses of healthcare workers (HCWs), a population that is immunocompetent, adherent to vaccination, and continuously exposed to different virus variants, can help us understand immune protection and determine vaccine design goals. Methods: We retrospectively evaluated antibody responses via multiplex assays in a sample of 538 asymptomatic HCWs with a documented complete vaccination cycle of 3 doses of mRNA vaccination and no previous history of infection. Our sample was composed of 49.44% males and 50.56% females, with an age ranging from 21 to 71 years, and a mean age of 46.73 years. All of the HCWs’ sera were collected from April to July 2022 at the Sant’Elia Hospital of Caltanissetta to investigate the immunologic responses against anti-RBD, anti-S1, anti-S2, and anti-N IgG abs. Results: A significant difference in age between HCWs who were positive and negative for anti-N IgG was observed. For anti-S2 IgG, a significant difference between HCWs who were negative and positive compared to anti-N IgG was observed only for positive HCWs, with values including 10 (U/mL)–100 (U/mL); meanwhile, for anti-RBD IgG and anti-S1 IgG levels, there was only a significant difference observed for positive HCWs with diluted titers. For the negative values of anti-N IgG, among the titer dilution levels of anti-RBD, anti-S1, and anti-S2 IgG, the anti-S2 IgG levels were significantly lower than the anti-RBD and anti-S1 levels; in addition, the anti-S1 IgG levels were significantly lower than the anti-RBD IgG levels. For the anti-N IgG positive levels, only the anti-S2 IgG levels were significantly lower than the anti-RBD IgG and anti-S1 IgG levels. Finally, a logistic regression analysis showed that age and anti-S2 IgG were negative and positive predictors of anti-N IgG levels, respectively. The analysis between the vaccine type and mixed mRNA combination showed higher levels of antibodies in mixed vaccinated HCWs. This finding disappeared in the anti-N positive group. Conclusions: Most anti-N positive HCWs showed antibodies against the S2 domain and were young subjects. Therefore, the authors suggest that including the anti-SARS-CoV-2-S2 in antibody profiles can serve as a complementary testing approach to qRT-PCR for the early identification of asymptomatic infections in order to reduce the impact of potential new SARS-CoV-2 variants. Our serological investigation on the type of mRNA vaccine and mixed mRNA vaccines shows that future investigations on the serological responses in vaccinated asymptomatic patients exposed to previous infection or reinfection are warranted for updated vaccine boosters.

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Section: Introductionmentioning

confidence: 99%

A Serological Analysis of the Humoral Immune Responses of Anti-RBD IgG, Anti-S1 IgG, and Anti-S2 IgG Levels Correlated to Anti-N IgG Positivity and Negativity in Sicilian Healthcare Workers (HCWs) with Third Doses of the mRNA-Based SARS-CoV-2 Vaccine: A Retrospective Cohort Study

Serra,

Andriolo,

Butera

et al. 2023

Vaccines

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“…This crisis has led to the stagnation of coastal tourism owing to border closures and restrictions on the movement of people [2]. Moreover, the crisis has had a complex impact on tourism flows in the Asia-Pacific international coastal tourism region because of the difference between the "clean-up" model in East Asia and the "co-existence" model in Europe and the US [3]. The recent socioeconomic turmoil in Sri Lanka, an important coastal tourism destination, was also impacted by the outbreak [4].…”

Section: Introductionmentioning

confidence: 99%

Impact and Recovery of Coastal Tourism Amid COVID-19: Tourism Flow Networks in Indonesia

et al. 2022

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This study aims to explore tourism changes in coastal tourism destinations before and during the COVID-19 pandemic from the perspective of regional resilience. A mixed method of a social network and spatial analysis was used to evaluate inbound tourists’ geotagged photos of Indonesia on Flickr from 2018–2022 as metadata. The DBSCAN algorithm and Markov chains were used to comprehensively analyze the hotspot areas and the patterns of tourism movement trajectories amid a complicated recovery. The results demonstrate that: (1) The distribution of geotagged photos before and during the pandemic generally exhibited stage and regional unevenness. The main clusters were Java and the Nusa Tenggara Islands, with the rest displaying a scattered distribution. (2) The tourism flow network was unevenly distributed, and the nodes had obvious core and edge areas. Owing to the crisis, the tourism flow network realized a change in form from network to line and point. (3) Its impact on Indonesian inbound tourism may persist in the short term, and the volatility of national anti-pandemic policies influences the resilience of tourism flow during COVID-19. The dominance of the core nodes highlights the network’s resistance to disruptions due to the prominence of the location of network connections during the pandemic, and marginal nodes reflect the vulnerability to pandemic shocks owing to the hypocentricity of the nodes and the thinness of the connections within and outside the islands. These results provide marketing and promotion policies for the sustainable development of coastal areas.

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Exploring the Role of Serology Testing to Strengthen Vaccination Initiatives and Policies for COVID-19 in Asia Pacific Countries and Territories: A Discussion Paper

Cited by 2 publications

References 180 publications

A Serological Analysis of the Humoral Immune Responses of Anti-RBD IgG, Anti-S1 IgG, and Anti-S2 IgG Levels Correlated to Anti-N IgG Positivity and Negativity in Sicilian Healthcare Workers (HCWs) with Third Doses of the mRNA-Based SARS-CoV-2 Vaccine: A Retrospective Cohort Study

A Serological Analysis of the Humoral Immune Responses of Anti-RBD IgG, Anti-S1 IgG, and Anti-S2 IgG Levels Correlated to Anti-N IgG Positivity and Negativity in Sicilian Healthcare Workers (HCWs) with Third Doses of the mRNA-Based SARS-CoV-2 Vaccine: A Retrospective Cohort Study

Impact and Recovery of Coastal Tourism Amid COVID-19: Tourism Flow Networks in Indonesia

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