Exploring the Possible Mechanism and Drug Targets of Huang‐Qi‐Gui‐Zhi‐Wu‐Wu Decoction for the Treatment of Chemotherapy‐Induced Peripheral Neuropathy on Network Pharmacology

Gu, Jialin; Wei, Guoli; Ma, Yuzhu; Zhang, Jinzhi; Yi, Ji; Li, Ling-Chang; Yu, Jialin; Hu, Canhong; Huo, Jiege

doi:10.1155/2020/2363262

Cited by 13 publications

(8 citation statements)

References 59 publications

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“…Currently, Huang-qi-gui-zhiwu-wu-tang is mainlyused to treat hand-foot syndrome, CIPN, diabetic peripheral neuropathy, and rheumatoid arthritis. Gu et al used the network pharmacology approach to investigate the potential pathogenesis of CIPN and the therapeutic mechanisms by which Huangqi-gui-zhi-wu-wu-tang treated CIPN (68). They indicated that the main pathologies of CIPN might involve the inflammatory response and nerve injury and that Huangqi-gui-zhi-wu-wu-tang played a therapeutic role in CIPN by regulating the inflammatory response and repairing nerve injury, thus verifying the reliability and efficacy of this herbal formula.…”

Section: Peripheral Neuropathymentioning

confidence: 99%

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

Zhang

Qiu²,

et al. 2021

BST

151

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Table 2. Some Chinese herbal formulas as adjuvant therapy for cancer Note: Abbreviations: cancer-related fatigue (CRF); quality of life (QOL); epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs); Common name Bu-zhong-yi-qi-tang Shi-quan-da-bu-tang Liu-jun-zi-tang Sheng-jiang-xie-xintang Huang-qi-gui-zhiwu-wu-tang Ban-xia-xie-xin-tang Other names Hochuekki-to or TJ-41 in Japanese; Bojungikki-Tang in Korean Juzentaiho-to or TJ-48 in Japanese, Sipjeondaebotang in Korean Yukgunja-tang in Korean, Rikkunshito or TJ-43 in Japanese None AC591 Ban-xia-xie-xintang in Chinese or Hangeshashinto or TJ-14 in Japanese Biological activity Antitumor action, immunomodulation, and alleviation of fatigue Antitumor, immunomodulation, and alleviation of fatigue Gastroprotective action Gastroprotective action Alleviation of limb numbness and pain Antioxidant action, antiinflammatory, bactericidal, and analgesic action as well as action to promote healing

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Section: Peripheral Neuropathymentioning

confidence: 99%

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

Zhang

Qiu²,

et al. 2021

BST

151

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“…TCM and its compound prescriptions have the effects of multiple components and multiple targets. The research in the new field of “traditional Chinese medicine network pharmacology” is based on the theory of systems biology, aims to reveal the mystery of TCM prescriptions at the system level and molecular level, and promote the shift of TCM research mode from the current “single target, single drug” model to a new model of “network target, multicomponent drugs.” Preliminary research results indicate that TCM network pharmacology can provide a new way for TCM to move from experience-based medicine to evidence-based medicine and accelerate the process of TCM drug discovery, while improving current drug research strategies and enabling preliminary analysis of drugs affecting the disease network [ 11 – 13 ]. In this study, we screened the main active ingredients of Mufangji Decoction through network pharmacology and found that patchouli alcohol (PA) is an important active ingredient of Mufangji Decoction.…”

Section: Discussionmentioning

confidence: 99%

Mufangji Decoction and Its Active Ingredient Patchouli Alcohol Inhibit Tumor Growth through Regulating Akt/mTOR-Mediated Autophagy in Nonsmall-Cell Lung Cancer

Yang

Chen

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Nonsmall-cell lung cancer (NSCLC) is the main type of lung cancer, whose morbidity and mortality rank first among malignant tumors. More than 70% of NSCLC patients are diagnosed at locally advanced or advanced stage, missing the best operation period. Chemotherapy and targeted therapy are important means for the treatment of advanced NSCLC, but various side effects seriously affect the curative effect and the life quality of NSCLC patients. Our previous clinical practice has shown that Mufangji Decoction, a classic traditional Chinese medicine, has a significant curative effect in the treatment of NSCLC, but the specific mechanism is not clear. This study intends to explore the potential mechanism of Mufangji Decoction and its active ingredient patchouli alcohol against NSCLC and to provide a scientific basis for the prevention and treatment of NSCLC by traditional Chinese medicine. Methods. The in vivo and in vitro experiments were performed to evaluate the antitumor effects and investigate the underlying mechanism of Mufangji Decoction and its active ingredient patchouli alcohol. Network pharmacology was applied to analyze the effective ingredients and potential targets or signaling pathways of Mufangji Decoction. Results. Our current study shows that Mufangji Decoction can effectively inhibit the growth of subcutaneous transplantation of NSCLC. The following network pharmacological analysis and in vivo experiment suggest that patchouli alcohol is one of the main active ingredients of Mufangji Decoction and exerts antitumor effects. Further mechanism investigation reveals that the antitumor effect of patchouli alcohol is related to the induction of Akt/mTOR signaling pathway-mediated autophagy in NSCLC cells. Conclusion. Mufangji Decoction and its active ingredient patchouli alcohol might exert their antitumor effects in NSCLC partly through regulating Akt/mTOR-mediated autophagy, providing the evidence that traditional Chinese medicine might be a key approach for NSCLC treatment via targeting the Akt/mTOR signal axis.

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“…A previous study has reported that various herbs, including EAHM, relieve neuropathy symptoms through serotonin 5-HT1A receptors, inhibit axonal degeneration, improve axonal transport, and suppress TNF-α and NO in CIPN [15]. In contrast, the Huang-Qi-Gui-Zhi-Wu-Wu decoction, an EAHM prescription widely used for a long time, can improve CIPN by controlling the inflammatory response and repairing nerve damage [16]. Radix Astragali, one of the most extensively prescribed herbs for chronic pain, including neuropathy, acts as a potential nerve growth factor to induce axon growth in peripheral nerves and promote nerve cell differentiation.…”

Section: How the Intervention Might Workmentioning

confidence: 99%

Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations

Lee

2021

Pharmaceuticals

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This review aimed to comprehensively assess the efficacy and safety of oral East Asian herbal medicine (EAHM) for overall peripheral neuropathy (PN). In addition, an Apriori algorithm-based association rule analysis was performed to identify the core herb combination, thereby further generating useful hypotheses for subsequent drug discovery. A total of 10 databases were searched electronically from inception to July 2021. Randomized clinical trials (RCTs) comparing EAHM with conventional analgesic medication or usual care for managing PN were included. The RCT quality was appraised using RoB 2.0, and the random effects model was used to calculate the effect sizes of the included RCTs. The overall quality of evidence was evaluated according to the Grading of Recommendations Assessment, Development, and Evaluation. By analyzing the constituent herb data, the potential association rules of core herb combinations were explored. A total of 67 RCTs involving 5753 patients were included in this systematic review. In a meta-analysis, EAHM monotherapy and combined EAHM and western medicine therapy demonstrated substantially improved sensory nerve conduction velocity, motor nerve conduction velocity, and response rate. Moreover, EAHM significantly improved the incidence rate, pain intensity, Toronto clinical scoring system, and Michigan diabetic neuropathy score. The evidence grade was moderate to low due to the substantial heterogeneity among the studies. Nine association rules were identified by performing the association rule analysis on the extraction data of 156 EAHM herbs. Therefore, the constituents of the herb combinations with consistent association rules were Astragali Radix, Cinnamomi Ramulus, and Spatholobi Calulis. This meta-analysis supports the hypothesis that EAHM monotherapy and combined therapy may be beneficial for PN patients, and follow-up research should be conducted to confirm the precise action target of the core herb.

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Exploring the Possible Mechanism and Drug Targets of Huang‐Qi‐Gui‐Zhi‐Wu‐Wu Decoction for the Treatment of Chemotherapy‐Induced Peripheral Neuropathy on Network Pharmacology

Cited by 13 publications

References 59 publications

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

The positive role of traditional Chinese medicine as an adjunctive therapy for cancer

Mufangji Decoction and Its Active Ingredient Patchouli Alcohol Inhibit Tumor Growth through Regulating Akt/mTOR-Mediated Autophagy in Nonsmall-Cell Lung Cancer

Oral Administration of East Asian Herbal Medicine for Peripheral Neuropathy: A Systematic Review and Meta-Analysis with Association Rule Analysis to Identify Core Herb Combinations

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