Exploring the impact of exercise and essential amino acid plus cholecalciferol supplementation on physical fitness and body composition in multiple sclerosis: A case study

Ispoglou, Theocharis; Ferentinos, Panagiotis; Prokopidis, Konstantinos; Blake, Cameron; Aldrich, Luke; Elia, Antonis; Lees, Matthew; Hind, Karen

doi:10.1002/ccr3.7548

Cited by 2 publications

(2 citation statements)

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“…The intervention included exercise interventions twice a week and the administration of dietary supplements containing 7.5 g of essential amino acids and 500 IU of cholecalciferol twice a day. 133 At week 24, the total lean body mass of the patient increased by 1.0%, and the lean body mass of the arms and legs increased by 6.9% and 6.3%, respectively. In a cross-sectional study, Rivadeneyra et al found that female Parkinson’s patients with low physical activity and low energy intake were more likely to develop sarcopenia.…”

Section: Combining Exercise With Dietary Supplementsmentioning

confidence: 92%

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Hu,

Wang,

et al. 2024

CIA

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This article focuses on a range of non-pharmacological strategies for managing sarcopenia in chronic diseases, including exercise, dietary supplements, traditional Chinese exercise, intestinal microecology, and rehabilitation therapies for individuals with limited limb movement. By analyzing multiple studies, the article aims to summarize the available evidence to manage sarcopenia in individuals with chronic diseases. The results strongly emphasize the role of resistance training in addressing chronic diseases and secondary sarcopenia. Maintaining the appropriate frequency and intensity of resistance training can help prevent muscle atrophy and effectively reduce inflammation. Although aerobic exercise has limited ability to improve skeletal muscle mass, it does have some positive effects on physical function. Building upon this, the article explores the potential benefits of combined training approaches, highlighting their helpfulness for overall quality of life. Additionally, the article also highlights the importance of dietary supplements in combating muscle atrophy in chronic diseases. It focuses on the importance of protein intake, supplements rich in essential amino acids and omega-3, as well as sufficient vitamin D to prevent muscle atrophy. Combining exercise with dietary supplements appears to be an effective strategy for preventing sarcopenia, although the optimal dosage and type of supplement remain unclear. Furthermore, the article explores the potential benefits of intestinal microecology in sarcopenia. Probiotics, prebiotics, and bacterial products are suggested as new treatment options for sarcopenia. Additionally, emerging therapies such as whole body vibration training, blood flow restriction, and electrical stimulation show promise in treating sarcopenia with limited limb movement. Overall, this article provides valuable insights into non-pharmacological strategies for managing sarcopenia in individuals with chronic diseases. It emphasizes the importance of a holistic and integrated approach that incorporates exercise, nutrition, and multidisciplinary interventions, which have the potential to promote health in the elderly population. Future research should prioritize high-quality randomized controlled trials and utilize wearable devices, smartphone applications, and other advanced surveillance methods to investigate the most effective intervention strategies for sarcopenia associated with different chronic diseases.

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Section: Combining Exercise With Dietary Supplementsmentioning

confidence: 92%

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Hu,

Wang,

et al. 2024

CIA

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“…Among these, home exercise, swimming, aerobic exercise, and resistance exercise, as well as a variety of combined exercise training programs, can improve glucose tolerance and reduce blood sugar levels and insulin resistance. Varying degrees of improvement have also been observed ( Patyn, 2014 ; Wens et al, 2015 ; Sadegh and Golestany, 2017 ; Wens et al, 2017 ; Ispoglou et al, 2023 ).…”

Section: Exercise Reduces Insulin Resistance and Improves Neurologica...mentioning

confidence: 97%

Potential molecular mechanism of exercise reversing insulin resistance and improving neurodegenerative diseases

Shen,

Wang,

Wang

et al. 2024

Front. Physiol.

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Neurodegenerative diseases are debilitating nervous system disorders attributed to various conditions such as body aging, gene mutations, genetic factors, and immune system disorders. Prominent neurodegenerative diseases include Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, and multiple sclerosis. Insulin resistance refers to the inability of the peripheral and central tissues of the body to respond to insulin and effectively regulate blood sugar levels. Insulin resistance has been observed in various neurodegenerative diseases and has been suggested to induce the occurrence, development, and exacerbation of neurodegenerative diseases. Furthermore, an increasing number of studies have suggested that reversing insulin resistance may be a critical intervention for the treatment of neurodegenerative diseases. Among the numerous measures available to improve insulin sensitivity, exercise is a widely accepted strategy due to its convenience, affordability, and significant impact on increasing insulin sensitivity. This review examines the association between neurodegenerative diseases and insulin resistance and highlights the molecular mechanisms by which exercise can reverse insulin resistance under these conditions. The focus was on regulating insulin resistance through exercise and providing practical ideas and suggestions for future research focused on exercise-induced insulin sensitivity in the context of neurodegenerative diseases.

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Exploring the impact of exercise and essential amino acid plus cholecalciferol supplementation on physical fitness and body composition in multiple sclerosis: A case study

Abstract: In MS patients, especially those frail or malnourished, combining home-based exercise twice weekly with essential amino acids and vitamin D may improve body composition, strength, and physical performance, enabling long-term functional improvements.

Cited by 2 publications

References 58 publications

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Non-Pharmacological Strategies for Managing Sarcopenia in Chronic Diseases

Potential molecular mechanism of exercise reversing insulin resistance and improving neurodegenerative diseases

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