Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review

Mitra, Saikat; Paul, Shyamjit; Roy, Soma; Sutradhar, Hriday; Emran, Talha Bin; Nainu, Firzan; Khandaker, Mayeen Uddin; Almalki, Mohammed; Wilairatana, Polrat; Mubarak, Mohammad S.

doi:10.3390/molecules27020555

Cited by 57 publications

(48 citation statements)

References 247 publications

(183 reference statements)

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“…Minerals are of paramount importance in order to preserve and obtain good health and their key role is supported by a significant amount of literature [ 3 ]. The crucial role of minerals shifts from helping vitamin absorption [ 4 ] and immunomodulatory effect [ 5 ] to metabolic [ 6 ] and bone metabolism [ 7 ], influencing hematological [ 8 ] and endocrine function [ 9 ]. The source of many important minerals is mainly plant-based therefore it is important to use a balanced diet to provide the adequate proportion of minerals [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

et al. 2022

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Diabetes is expected to increase up to 700 million people worldwide with type 2 diabetes being the most frequent. The use of nutritional interventions is one of the most natural approaches for managing the disease. Minerals are of paramount importance in order to preserve and obtain good health and among them molybdenum is an essential component. There are no studies about the consumption of biofortified food with molybdenum on glucose homeostasis but recent studies in humans suggest that molybdenum could exert hypoglycemic effects. The present study aims to assess if consumption of lettuce biofortified with molybdenum influences glucose homeostasis and whether the effects would be due to changes in gastrointestinal hormone levels and specifically Peptide YY (PYY), Glucagon-Like Peptide 1 (GLP-1), Glucagon-Like Peptide 2 (GLP-2), and Gastric Inhibitory Polypeptide (GIP). A cohort of 24 people was supplemented with biofortified lettuce for 12 days. Blood and urine samples were obtained at baseline (T0) and after 12 days (T2) of supplementation. Blood was analyzed for glucose, insulin, insulin resistance, β-cell function, and insulin sensitivity, PYY, GLP-1, GLP-2 and GIP. Urine samples were tested for molybdenum concentration. The results showed that consumption of lettuce biofortified with molybdenum for 12 days did not affect beta cell function but significantly reduced fasting glucose, insulin, insulin resistance and increased insulin sensitivity in healthy people. Consumption of biofortified lettuce did not show any modification in urine concentration of molybdenum among the groups. These data suggest that consumption of lettuce biofortified with molybdenum improves glucose homeostasis and PYY and GIP are involved in the action mechanism.

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Section: Introductionmentioning

confidence: 99%

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

et al. 2022

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“…In addition, TLR4 suppression prevented the GLE-mediated production of immunomodulators as well as activation of the p38, JNK, and NF-κB transcriptional factors. Together, our findings revealed that the TLR4-MAPK/NF-κB-signaling pathways were involved in GLE-induced macrophage activation and that GLE might be developed as a potential immunomodulatory functional food ingredient [ 122 , 123 ].…”

Section: Health Benefits and Risks Of Lettucementioning

confidence: 98%

Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review

Shi

et al. 2022

Antioxidants

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Lettuce is one of the most famous leafy vegetables worldwide with lots of applications from food to other specific uses. There are different types in the lettuce group for consumers to choose from. Additionally, lettuce is an excellent source of bioactive compounds such as polyphenols, carotenoids, and chlorophyll with related health benefits. At the same time, nutrient composition and antioxidant compounds are different between lettuce varieties, especially for green and red lettuce types. The benefit of lettuce consumption depends on its composition, particularly antioxidants, which can function as nutrients. The health benefits rely on their biochemical effect when reaching the bloodstream. Some components can be released from the food matrix and altered in the digestive system. Indeed, the bioaccessibility of lettuce is measuring the quantity of these compounds released from the food matrix during digestion, which is important for health-promoting features. Extraction of bioactive compounds is one of the new trends observed in lettuce and is necessarily used for several application fields. Therefore, this review aims to demonstrate the nutritional value of lettuce and its pharmacological properties. Due to their bioaccessibility and bioavailability, the consumer will be able to comprehensively understand choosing a healthier lettuce diet. The common utilization pattern of lettuce extracted nutrients will also be summarized for further direction.

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“…Resveratrol is a polyphenol that is found in the extract of Vitis vinifera [ 149 ]. It possesses a wide range of bioactivities, including hepatoprotective, anti-cancer, anti-inflammatory, immunomodulatory, antidiabetic, and other properties [ 132 , 150 , 151 ]. In many rodent models, resveratrol has been shown to treat diabetes [ 152 , 153 ] and its complications [ 154 , 155 , 156 , 157 , 158 , 159 ].…”

Section: Phytogenic Compoundsmentioning

confidence: 99%

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

et al. 2022

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Obesity and diabetes are the most demanding health problems today, and their prevalence, as well as comorbidities, is on the rise all over the world. As time goes on, both are becoming big issues that have a big impact on people’s lives. Diabetes is a metabolic and endocrine illness set apart by hyperglycemia and glucose narrow-mindedness because of insulin opposition. Heftiness is a typical, complex, and developing overall wellbeing worry that has for quite some time been connected to significant medical issues in individuals, all things considered. Because of the wide variety and low adverse effects, herbal products are an important hotspot for drug development. Synthetic compounds are not structurally diverse and lack drug-likeness properties. Thus, it is basic to keep on exploring herbal products as possible wellsprings of novel drugs. We conducted this review of the literature by searching Scopus, Science Direct, Elsevier, PubMed, and Web of Science databases. From 1990 until October 2021, research reports, review articles, and original research articles in English are presented. It provides top to bottom data and an examination of plant-inferred compounds that might be utilized against heftiness or potentially hostile to diabetes treatments. Our expanded comprehension of the systems of activity of phytogenic compounds, as an extra examination, could prompt the advancement of remedial methodologies for metabolic diseases. In clinical trials, a huge number of these food kinds or restorative plants, as well as their bioactive compounds, have been shown to be beneficial in the treatment of obesity.

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Exploring the Immune-Boosting Functions of Vitamins and Minerals as Nutritional Food Bioactive Compounds: A Comprehensive Review

Cited by 57 publications

References 247 publications

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

Impact on Glucose Homeostasis: Is Food Biofortified with Molybdenum a Workable Solution? A Two-Arm Study

Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review

The Multifunctional Role of Herbal Products in the Management of Diabetes and Obesity: A Comprehensive Review

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