Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes

Matos, Carla; Addis, Yemataw; Nunes, Patrique; Barroso, Sónia; Alho, Irina; Martins, Marta; Matos, António P.; Marques, Fernanda; Cavaco, Isabel; Pessoa, João Costa; Correia, Isabel

doi:10.1016/j.jinorgbio.2019.110727

Cited by 43 publications

(36 citation statements)

References 87 publications

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“…Similar results of Cu II complexes were reported where Cu–O caboxylate and Cu–N pyridine bond lengths have been ranged from 1.991–2.176 Å to 1.875–2.174 Å, respectively . Similarly, bond lengths of Zn II complexes were reported in a recent literature, where Zn–O caboxylate and Zn–N phen bond lengths have been in the range of 2.064 Å to 2.172 and 2.135 Å to 2.157 Å, respectively . The average bond angles for complexes 1 – 4 are calculated as O–M–O; 9.443°, 94.65°, 106.258°, 134.7° O–M–N; 112.898°, 129.26°, 105.97°, 107.2° and N–M–N; 79.88°, 81.00°, 76.98° and 78.4°, respectively.…”

Section: Resultssupporting

confidence: 80%

Synthesis, Characterization, Structural Description, Micellization Behavior, DNA Binding Study and Antioxidant Activity of 4, 5 and 6‐Coordinated Copper(II) and Zinc(II) Complexes

Iqbal

Karim

Ali

et al. 2020

Zeitschrift anorg allge chemie

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Four mononuclear copper(II) and zinc(II) complexes were synthesized by the reaction of copper and zinc salts with 3,4‐dichlorophenylactic acid, 2‐bromophenylactic acid, biphenylacetic acid (O‐donor ligand) and bipyridine (N‐donor ligands) having the general formulae [(L)2Cu(bp)(H2O)] (1), [(BpA)2Cu(bp)] (2), [(L)2Zn(bp)(H2O)] (3) and [(L*)2Zn(bp)] (4) (L = 3,4‐dichlorophenylacetate, L* = 2‐bromophenylacetate bp = bipyridine, and BpA = biphenylacetate). Structures of all compounds were characterized through FT‐IR spectroscopy and X‐ray diffraction analysis. FT‐IR spectra of all complexes confirmed the binding mode of Cu‐O and Zn‐O. XRD data revealed that complexes 1–3 exhibited distorted octahedral arrangement, whereas complex 4 has a distorted tetrahedral environment. Micellization behavior was examined with anionic surfactant (SDS) by conductance measurement as well as absorption spectral analysis. DNA binding study was assessed through viscosity measurement and UV/Vis spectrophotometry. DPPH free radical scavenging assay was measured by UV/Vis spectrophotometry. The results showed nice biological potential of all the complexes.

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Section: Resultssupporting

confidence: 80%

Synthesis, Characterization, Structural Description, Micellization Behavior, DNA Binding Study and Antioxidant Activity of 4, 5 and 6‐Coordinated Copper(II) and Zinc(II) Complexes

Iqbal

Karim

Ali

et al. 2020

Zeitschrift anorg allge chemie

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“…The protein solutions were pre-incubated for 2 h at 37 °C to form the complex/protein adducts. During incubation for 72 h with A2780 cells, the medium supplement fetal bovine serum was reduced to 5% [63,64]. The MTT assay was performed as described above.…”

Section: Methodsmentioning

confidence: 99%

Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity

et al. 2019

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The steady rise in the cancer burden and grim statistics set a vital need for new therapeutic solutions. Given their high efficiency, metallodrugs are quite appealing in cancer chemotherapy. This work examined the anticancer activity of an anti-trypanosomal ruthenium-based compound bearing the 5-nitrofuryl pharmacophore, [RuII(dmso)2(5-nitro-2-furaldehyde semicarbazone)] (abbreviated as RuNTF; dmso is the dimethyl sulfoxide ligand). The cytotoxicity of RuNTF was evaluated in vitro against ovarian adenocarcinoma, hormone-dependent breast adenocarcinoma, prostate carcinoma (grade IV) and V79 lung fibroblasts human cells. The activity of RuNTF was similar to the benchmark metallodrug cisplatin for the breast line and inactive against the prostate line and lung fibroblasts. Given the known role of serum protein binding in drug bioavailability and the distribution via blood plasma, this study assessed the interaction of RuNTF with human serum albumin (HSA) by circular dichroism (CD) and fluorescence spectroscopy. The fluorescence emission quenching from the HSA-Trp214 residue and the lifetime data upon RuNTF binding evidenced the formation of a 1:1 {RuNTF-albumin} adduct with log Ksv = (4.58 ± 0.01) and log KB = (4.55 ± 0.01). This is supported by CD data with an induced CD broad band observed at ~450 nm even after short incubation times. Importantly, the binding to either HSA or human apo-transferrin is beneficial to the cytotoxicity of the complex towards human cancer cells by enhancing the cytotoxic activity of RuNTF.

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“…10,11 Zn(II), a ubiquitous ion essential to all life forms, is one of the most important metals involved in immune functions, cellular biochemical reactions, DNA synthesis, catalysis, cell division, and protein synthesis. [12][13][14][15] Indeed, there has been an increasing interest in Zn(II) and its complexes because of their roles in biological functions, versatility in fluorescence imaging, use in photodynamic therapy, use as a photon fluorescent probe, and antitumor activity. In particular, Zn(II) bis(thiosemicarbazonato) probes, 16,17 Zn(II) phthalocyanine photodynamic drugs, [18][19][20][21][22][23][24][25][26][27][28][29][30][31] Zn(II)-2,2′-dipicolylamine derivatives, 32-39 benzo[d] imidazole Zn(II) complexes, 40,41 and Zn(II) terpyridine-phenanthroline complexes 42,43 have gained popularity.…”

Section: Introductionmentioning

confidence: 99%

Complexes of Zn(ii) with a mixed tryptanthrin derivative and curcumin chelating ligands as new promising anticancer agents

Wang

Nong

et al. 2022

Dalton Trans.

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Exploring the cytotoxic activity of new phenanthroline salicylaldimine Zn(II) complexes

Cited by 43 publications

References 87 publications

Synthesis, Characterization, Structural Description, Micellization Behavior, DNA Binding Study and Antioxidant Activity of 4, 5 and 6‐Coordinated Copper(II) and Zinc(II) Complexes

Synthesis, Characterization, Structural Description, Micellization Behavior, DNA Binding Study and Antioxidant Activity of 4, 5 and 6‐Coordinated Copper(II) and Zinc(II) Complexes

Interaction with Blood Proteins of a Ruthenium(II) Nitrofuryl Semicarbazone Complex: Effect on the Antitumoral Activity

Complexes of Zn(ii) with a mixed tryptanthrin derivative and curcumin chelating ligands as new promising anticancer agents

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