Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases

Vo, Thuy-Trang T; Kong, Gyeyeong; Kim, Chaeyeong; Juang, Uijin; Gwon, Suhwan; Jung, Woohyeong; Nguyen, Huonggiang; Kim, Seon‐Hwan; Park, Jongsun

doi:10.1007/s43188-023-00176-2

Toxicol Res.

2023

DOI: 10.1007/s43188-023-00176-2

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Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases

Thuy-Trang T Vo

Gyeyeong Kong

Chaeyeong Kim

et al.

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2024

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Cited by 3 publications

References 105 publications

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Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis

Janyasupab,

Singhanat,

Warnnissorn

et al. 2024

Biomolecules

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Breast cancer has the highest diagnosis rate among all cancers. Tumor budding (TB) is recognized as a recent prognostic marker. Identifying genes specific to high-TB samples is crucial for hindering tumor progression and metastasis. In this study, we utilized an RNA sequencing technique, called TempO-Seq, to profile transcriptomic data from breast cancer samples, aiming to identify biomarkers for high-TB cases. Through differential expression analysis and mutual information, we identified seven genes (NOL4, STAR, C8G, NEIL1, SLC46A3, FRMD6, and SCARF2) that are potential biomarkers in breast cancer. To gain more relevant proteins, further investigation based on a protein–protein interaction network and the network diffusion technique revealed enrichment in the Hippo signaling and Wnt signaling pathways, promoting tumor initiation, invasion, and metastasis in several cancer types. In conclusion, these novel genes, recognized as overexpressed in high-TB samples, along with their associated pathways, offer promising therapeutic targets, thus advancing treatment and diagnosis for breast cancer.

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Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis

Janyasupab,

Singhanat,

Warnnissorn

et al. 2024

Biomolecules

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MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)

Jung,

Juang,

Gwon

et al. 2024

Mol Med Rep

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Muscular atrophy, which results in loss of muscle mass and strength, is a significant concern for patients with various diseases. it is crucial to comprehend the molecular mechanisms underlying this condition to devise targeted treatments. Micrornas (mirnas) have emerged as key regulators of gene expression, serving vital roles in numerous cellular processes, including the maintenance of muscle stability. an intricate network of miRNAs finely regulates gene expression, influencing pathways related to muscle protein production, and muscle breakdown and regeneration. dysregulation of specific mirnas has been linked to the development of muscular atrophy, affecting important signaling pathways including the protein kinase B/mTor and ubiquitin-proteasome systems. The present review summarizes recent work on mirna patterns associated with muscular atrophy under various physiological and pathological conditions, elucidating its intricate regulatory networks. in conclusion, the present review lays a foundation for the development of novel treatment options for individuals affected by muscular atrophy, and explores other regulatory pathways, such as autophagy and inflammatory signaling, to ensure a comprehensive overview of the multifarious nature of muscular atrophy. The objective of the present review was to elucidate the complex molecular pathways involved in muscular atrophy, and to facilitate the development of innovative and specific therapeutic strategies for the prevention or reversal of muscular atrophy in diverse clinical scenarios. Contents1. introduction 2. Sarcopenia and muscular atrophy: Definitions, diagnoses and effects 3. mirnas regulated during disease-induced muscle loss 4. mirna-induced regulation of muscle differentiation 5. mirna-induced regulation of the ubiquitin proteasome system of skeletal muscle 6. mirna-induced regulation of cachexia 7. roles of regulatory mirnas in neurogenic muscular atrophy 8. Future perspectives

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Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)

Nguyen,

Kim,

Juang

et al. 2024

Mol Med Rep

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Exploring scavenger receptor class F member 2 and the importance of scavenger receptor family in prediagnostic diseases

Cited by 3 publications

References 105 publications

Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis

Identification of Tumor Budding-Associated Genes in Breast Cancer through Transcriptomic Profiling and Network Diffusion Analysis

MicroRNA‑mediated regulation of muscular atrophy: Exploring molecular pathways and therapeutics (Review)

Overview of carboxyl‑terminal modulator protein 1 and its importance in various metabolic regulations (Review)

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