Exploration of the intracellular chiral metabolome in pediatric BCP-ALL: a pilot study investigating the metabolic phenotype of IgH locus aberrations
Meghan Collins,
Ruggiero Gorgoglione,
Valeria Impedovo
et al.
Abstract:Background and aimsAberrations in the immunoglobulin heavy chain (IgH) locus are associated with poor prognosis in pediatric precursor B-cell acute lymphoblastic leukemia (BCP-ALL) patients. The primary objective of this pilot study is to enhance our understanding of the IgH phenotype by exploring the intracellular chiral metabolome.Materials and methodsLeukemia cells were isolated from the bone marrow of BCP-ALL pediatric patients at diagnosis. The samples’ metabolome and transcriptome were characterized usin… Show more
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