Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release

Kah, James Chen Yong; Chen, John; Zubieta, Angel; Hamad‐Schifferli, Kimberly

doi:10.1021/nn301389c

Cited by 169 publications

(197 citation statements)

References 73 publications

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“…On the other hand, the physicochemical characterization of bare NPs before exposure to body fluids remains crucial to reveal the correlations between the properties of NPs and PC composition (Figure 1). During the recent years, a large number of studies have been devoted to the characterization of NP-PC complexes [9][10][11][12][13][14][15][16][17][18][19][20][21][22][23]. Furthermore, the scientific community is now moving from the The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery The bare NP (synthetic identity) that has a specific shape, size and charge is injected into the body.…”

mentioning

confidence: 99%

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Corbo

Molinaro

Parodi

et al. 2015

Nanomedicine (Lond.)

536

443

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In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue. The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner. However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC). This can trigger an immune response and affect NP toxicity and targeting capabilities. In this review, we provide a survey of recent findings on the NP–PC interactions and discuss how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

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mentioning

confidence: 99%

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Corbo

Molinaro

Parodi

et al. 2015

Nanomedicine (Lond.)

536

443

View full text Add to dashboard Cite

show abstract

“…157 In the second approach, some groups have actually started to exploit the protein corona for drug loading and release. For example in one study, 175 both negatively charged oligonucleotides and positively charged doxorubicin were loaded in the protein corona of cetyltrimethylammonium bromide (CTAB)-coated gold nanorods. The holding capacity of protein corona on the nanorods was significantly higher than the covalent conjugation of therapeutics on NP surfaces.…”

Section: Complying With Protein Corona In Drug Deliverymentioning

confidence: 99%

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Bakhtiary

Saei

Hajipour

et al. 2016

Nanomedicine: Nanotechnology, Biology and Medicine

152

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Nanomedicine, the integration of nanotechnological tools in medicine demonstrated promising potential to revolutionize the diagnosis and treatment of various human health conditions. Nanoparticles (NPs) have shown much promise in diagnostics of cancer, especially since they can accommodate targeting molecules on their surface, which search for specific tumor cell receptors upon injection into the blood stream. This concentrates the NPs in the desired tumor location. Furthermore, such receptor-specific targeting may be exploited for detection of potential metastases in an early stage. Some NPs, such as superparamagnetic iron oxide NPs (SPIONs), are also compatible with magnetic resonance imaging (MRI), which makes their clinical translation and application rather easy and accessible for tumor imaging purposes. Furthermore, multifunctional and/or theranostic NPs can be used for simultaneous imaging of cancer and drug delivery. In this review article, we will specifically focus on the application of SPIONs in early detection and imaging of major cancer types.From the Clinical Editor: Super-paramagnetic iron oxide nanoparticles (SPIONs) have been reported by many to be useful as an MRI contrast agent in the detection of tumors. To further enhance the tumor imaging, SPIONs can be coupled with tumor targeting motifs. In this article, the authors performed a comprehensive review on the current status of using targeted SPIONS in tumor detection and also the potential hurdles to overcome. © 2015 Elsevier Inc. All rights reserved. 1 A significant improvement in cancer survival has been noted over the past three decades for most cancer types. This notable and continuous decrement in tumor fatality is related to advanced development in prevention, early diagnosis and therapeutic approaches and decrease in overall prevalence of smoking.1 Early detection of cancer, especially before cancer cells metastasize, is critical for cancer diagnosis, because early stage cancers can be treated more effectively. However, early-stage diagnosis has been difficult to achieve in most cases since clinical symptoms tend to show up at later stages. Therefore, minimally-and non-invasive methods for early detection of cancer are urgently needed in the field. In this regard, many SPION-based systems are under development for more sensitive imaging and earlier detection of tumors. Since non-targeted SPION species cannot readily differentiate cancer tissues from normal tissues, second-generation SPIONs have been developed which are equipped with targeting moieties that can recognize Nanomedicine: Nanotechnology, Biology, and Medicine 12 (2016) 287 -307

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“…A few recent studies have focused on the exploitation of the protein corona around NPs for drug loading and release. Recently, Kah et al [109] used the coronas of serum proteins on cetyltrimethylammonium bromide (CTAB)-coated gold nanorods for holding small molecular therapeutics (see Fig. 8).…”

Section: Opportunities Provided By Protein Coronamentioning

confidence: 99%

Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics

Saie

Ray

Rotello

2015

Cancer Treatment and Research

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Intracellular delivery of functional proteins using nanoparticles can be a game-changing approach for cancer therapy. However, cytosolic release of functional protein is still a major challenge. In addition, formation of protein corona on the surface of the nanoparticles can also alter the behavior of the nanoparticles. Here, we will review recent strategies for protein delivery into the cell. Finally we will discuss the issue of protein corona formation in light of nanoparticle-protein interactions.

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Exploiting the Protein Corona around Gold Nanorods for Loading and Triggered Release

Cited by 169 publications

References 73 publications

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

The Impact of Nanoparticle Protein Corona on Cytotoxicity, Immunotoxicity and Target Drug Delivery

Targeted superparamagnetic iron oxide nanoparticles for early detection of cancer: Possibilities and challenges

Engineering the Nanoparticle-Protein Interface for Cancer Therapeutics

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