Exploiting the protein corona around gold nanorods for low-dose combined photothermal and photodynamic therapy

Yeo, Eugenia Li Ling; Cheah, Joshua U-Jin; Neo, Dawn Jing Hui; Goh, Wah Ing; Kanchanawong, Pakorn; Soo, Khee Chee; Thong, Patricia S. P.; Kah, James Chen Yong

doi:10.1039/c6tb02743a

Cited by 77 publications

(91 citation statements)

References 102 publications

(148 reference statements)

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“…59 Few other studies have incorporated the same strategy for multimodal cancer therapy and combined photodynamic therapy (PDT) and photothermal therapy (PTT). 60,61 Apart from this, prodrug nanoassemblies with exposed surface maleimide groups could effectively recruit albumin corona upon incubation in rat plasma. The presence of albumin enhanced their accumulation in tumor cells and also was showed better activity as compared to commercially available Abraxane®.…”

Section: Employing Protein Corona For Drug Loadingmentioning

confidence: 99%

Understanding the relevance of protein corona in nanoparticle-based therapeutics and diagnostics

2020

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Section: Employing Protein Corona For Drug Loadingmentioning

confidence: 99%

Understanding the relevance of protein corona in nanoparticle-based therapeutics and diagnostics

2020

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“…However, the formation of this corona can also be employed as a targeting moiety or as drug transporter itself. Kah et al described the use of GNRs coated with a protein corona of human serum in which a photosensitizer (Chlorin e6) was loaded . The excitation at 665 nm generated fivefold‐times‐higher reactive oxidant species compared with free sensitizer, resulting in practically complete tumoral cell destruction at low dosages in the nanomolar range.…”

Section: Nanomaterials As Thermoseedsmentioning

confidence: 99%

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

et al. 2018

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that cancer cells are more sensitive to heat than normal ones [2,3] and the huge advances in the field of nanotechnology have given researchers new tools to design new, more sophisticated, and more specific heat treatments. Here, we focus on several electromagnetic responsive nanomaterials capable of acting as thermoseeds, which can induce changes in their environment through heating processes. We will pay special attention to the heat generation and its applications, as well as the biological response to the temperature rise at the nanoscale. Two sorts of nanomaterials that allow these new thermaltreatment approaches are especially attractive, depending on the radiation used to provoke the nanomaterial's response. Answering to the type of radiation used to carry out hyperthermia treatments, the nanomaterial characteristics required are completely different. The first application is typically called magnetic hyperthermia (MH), which uses alternating magnetic fields (AMFs); which are electromagnetic (EM) waves in the range of the EM spectrum that corresponds to radiofrequency (RF). The second, typically called optical hyperthermia, uses radiation in the part of the EM spectrum that corresponds to the near-infrared (NIR).The first approaches in hyperthermia treatments in both optical and magnetic stimuli mediated by nanoparticles were focused on the idea of using high doses of nanomaterials to produce enough heat to kill cancer cells by a global temperature increase. Researchers working in this field have to face several drawbacks, as the difficulty of localizing a high concentration of material in the target tissue, inadequate animal models, inaccurate temperature measurement, or limitations of the source conditions that can be used for in vivo experiments make the temperature rise often insufficient. [4] First, it is important to consider that the half-life and tissue penetration of the nanocarrier does not depend on the nanoparticle nature but on the coatings developed to enhance their stability in the physiological environment. Therefore, besides the heating efficiency, the predominant factor in the choice of hyperthermia generation is restricted by the location of the cancer tissue. Both RF and NIR irradiation can be considered useful external and noninvasive stimuli, but the main difference between the two is the tissue penetration. While magnetic fields Nanocarriers for cancer therapy have been extensively studied, but there is still some research that must be addressed in order to achieve their safe application. In this field, hyperthermia thermal treatments mediated by the use of responsive nanomaterials are not different, and researchers have carried out many attempts to overcome their drawbacks due to the valuable potential of these techniques. Here, an overview is presented of nanodevices based on magnetic-and photoresponsive nanocrystals that respond to magnetic fields and/or near-infrared stimuli for cancer therapies. Special attention is given to the synergic effect that can be achieved with nanoscal...

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“…Therefore, PC could be exploited as a biocompatible drug depot beside the therapeutic applications of NP itself. 31 In a preliminary study in this field in 2012, Kah et al 29 confirmed the possibility of DNA oligonucleotides and Doxorubicin loading onto PC around gold nanorods. By the same rationale, Shahabi et al 16 succeeded in an attempt to prepare a co-delivery system by loading hydrophilic doxorubicin and hydrophobic meloxicam onto fetal calf serum protein corona.…”

Section: Drug Loading On Corona-coated Gnpsmentioning

confidence: 98%

“…Therefore, the findings and previous reports inspired us to exploit protein corona as a sponge-like drug depot for the drugs in this study. In this regard, the PC around gold nanorods was used for loading a hydrophobic photosensitizer chlorin e6 solely for photodynamic/thermal therapy 31 and in combination with Doxorubicin for additional simultaneous chemotherapy. 32 In the previous studies, the colloidal stability of the nanoparticles was in a good condition after coating by PC.…”

Section: Drug Loading On Corona-coated Gnpsmentioning

confidence: 99%

<p>Targeting Tumorigenicity of Breast Cancer Stem Cells Using SAHA/Wnt-b Catenin Antagonist Loaded Onto Protein Corona of Gold Nanoparticles</p>

Shamsian¹,

Sepand²,

Kachousangi³

et al. 2020

IJN

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Background: Among various theories for the origin of cancer, the "stemness phenotype model" suggests a dynamic feature for tumor cells in which non-cancer stem cells (non-CSCs) can inter-convert to CSCs. Differentiation with histone-deacetylase inhibitor, vorinostat (SAHA), can induce stem cells to differentiate as well as enforces non-CSCs to reprogram to CSCs. To avoid this undesirable effect, one can block the Wnt-βcatenin pathway. Thus, a dual delivery system of SAHA and a Wnt-βcatenin blocker will be beneficial in the induction of differentiation of CSCs. Protein corona (PC) formation in nanoparticle has a biologic milieu, and despite all problematic properties, it can be employed as a medium for dual loading of the drugs. Materials and Methods: We prepared sphere gold nanoparticles (GNPs) with human plasma protein corona loaded with SAHA as differentiating agent and PKF118-310 (PKF) as a Wnt-βcatenin antagonist. The MCF7 breast cancer stem cells were treated with NPs and the viability and differentiation were evaluated by Western blotting and sphere formation assay. Results: We found that both drugs loaded onto corona-capped GNPs had significant cytotoxicity in comparison to bare GNP-corona. Data demonstrated an increase in stem cell population and upregulation of mesenchymal marker, Snail by SAHA-loaded GNPs treatment; however, the combination of PKF loaded GNPs along with SAHA-loaded GNPs resulted in a reduction of stem cell populations and Snail marker. We have shown that in MCF7 and its CSCs simultaneous treatment with SAHA and PKF118-310 induced differentiation and inhibition of Snail induction. Conclusion: Our study reveals the PC-coated GNPs as a biocompatible career for both hydrophilic (PKF) and hydrophobic (SAHA) agents which can decrease breast cancer stem cell populations along with reduced stemness state regression.

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Exploiting the protein corona around gold nanorods for low-dose combined photothermal and photodynamic therapy

Abstract: We load Ce6 onto NRs using its protein corona, deliver them to cells before performing laser irradiation for simultaneous PTT and PDT with greatly enhanced therapeutic efficacy.

Cited by 77 publications

References 102 publications

Understanding the relevance of protein corona in nanoparticle-based therapeutics and diagnostics

Understanding the relevance of protein corona in nanoparticle-based therapeutics and diagnostics

Heating at the Nanoscale through Drug‐Delivery Devices: Fabrication and Synergic Effects in Cancer Treatment with Nanoparticles

<p>Targeting Tumorigenicity of Breast Cancer Stem Cells Using SAHA/Wnt-b Catenin Antagonist Loaded Onto Protein Corona of Gold Nanoparticles</p>

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