Exploiting anthracene photodimerization within peptides: light induced sequence-selective DNA binding

Abstract

The unprecedented use of anthracene photodimerization within a protein or peptide system is explored through its incorporation into a DNA-binding peptide, derived from the GCN4 transcription factor. This study demonstrates an effective and dynamic interplay between a photoreaction and a peptide-DNA assembly, with each process able to exert control over the other.

Tunable helicity, stability and DNA-binding properties of short peptides with hybrid metal coordination motifs

“…Starting with the pioneering work by Kim, 54,61 several synthetic strategies have been developed for the dimerization of bZIP peptides, 55,62-64 including disulfide bonding, 54 metal coordination, 65-68 and crosslinking with metal-tunable 69 or photo-switchable linkers. 70-72 These studies have collectively shown the importance of the dimeric organization of the basic domains as well as their proper orientation for DNA binding and recognition. The HCM-based approach that we have described here is complementary to these previously described strategies.…”

A Photo‐Responsive Organogel Based on Pyrene‐Substituted Acylhydrazone Derivative

“…Visible light irradiation leads to efficient configurational transformation into cis-isomer. A photostationary state containing 61.1% of cis-isomer was obtained after being irradiated for about 1.5 h. In addition, cis-isomer of PAH-8 is stable at room temperature whereas it almost completely transforms into trans-isomer by heating for 1 h at 120 ℃ in DMSO-d 6 . Similar results were observed after UV light irradiation ( Figure S10), but only the 30.6% of cis-isomer was obtained after being irradiated by UV for about 8 h ( Figure S11), and the cis-isomer of PAH-8 could not transform into transisomer by heating.…”

“…Low molecular mass organogelators (LMOGs) can self-assemble through specific noncovalent interactions such as hydrogen bonding, π-π interaction, hydrophobic interaction or Van der Waals force to form diverse nano/micro-structures such as fibers, particles, tubes, and helical ribbons. [1][2][3] Recently, numerous efforts have been devoted to the development of stimuli-responsive organogels, whose properties can be either switched on-off or tuned in the presence of an external or internal chemical or physical stimulus such as light, [4][5][6][7] thermal treating, [8] ultrasound, [9] anion. [10] Among the stimuli-responsive organogels, photo-responsive organogels have attracted considerable attention because light is a non-contaminating stimulus that provides a broad range of tunable parameters.…”

Synthesis, characterization, DNA binding, cytotoxicity and molecular docking properties of Cu (II) and Mn (II) complexes with 1,4‐bis (pyrazol‐1‐yl) terephthalic acid

“…Structure and design of metal-involved supramolecular architectures based on crystal engineering are currently of interest in the field of supramolecular chemistry and coordination chemistry. [1][2][3][4] The increasing interest in this field is justified not only by their valuable unit structure, but also their potential applications in luminescence, catalysis and biochemistry, [5][6][7][8][9] particularly in modern medicinal chemistry. [6,[10][11][12][13] Among the series of compounds fabricated, the functional complexes attract great attention due to the potential drug value applications.…”

“…Intramolecular weak interactions, such as hydrogen bonds, and intermolecular interactions play important roles in the construction of the complexes. The interaction of these complexes with fish sperm DNA (FS-DNA) was monitored and binding constants were determined using UV-visible spectroscopy, which revealed their ability to bind to FS-DNA, with binding constants for the two complexes of 1.88 × 10 4 M −1 (1) and 1.06 × 10 4 M −1 (2). Viscosity experiments further demonstrated the binding of the complexes to DNA.…”