In this paper, I consider the relationship between Inference to the Best Explanation (IBE) and Bayesianism, both of which are well-known accounts of the nature of scientific inference. In section 1, I give a brief overview of Bayesianism and IBE. In section 2, I argue that IBE in its most prominently defended forms is difficult to reconcile with Bayesianism because not all of the items that feature on popular lists of "explanatory virtues"-by means of which IBE ranks competing explanations-have confirmational import. Rather, some of the items that feature on these lists are "informational virtues"-properties that do not make a hypothesis H1 more probable than some competitor H2 given evidence E, but that, roughly-speaking, give that hypothesis greater informative content. In section 3, I consider as a response to my argument a recent version of compatibilism which argues that IBE can provide further normative constraints on the objectively correct probability function. I argue that this response does not succeed, owing to the difficulty of defending with any generality such further normative constraints. Lastly, in section 4, I propose that IBE should be regarded, not as a theory of scientific inference, but rather as a theory of when we ought to "accept" H, where the acceptability of H is fixed by the goals of science and concerns whether H is worthy of commitment as research program. In this way, IBE and Bayesianism, as I will show, can be made compatible, and thus the Bayesian and the proponent of IBE can be friends.