Explaining variability in early stages of [18F]‐flortaucipir tau‐PET binding: Focus on sex differences
Dario Bachmann,
Andreas Buchmann,
Sandro Studer
et al.
Abstract:INTRODUCTIONFemale sex is associated with increased [18F]‐flortaucipir signal, which may be affected by amyloid pathology, age, and off‐target binding in skull and meninges.METHODSIn this cross‐sectional study comprising 52 females and 52 matched males, we examined sex‐related differences in regional tau‐positron emission tomography (PET) with and without considering off‐target binding. We assessed the respective contributions of sex, age, amyloid‐PET burden, and off‐target binding to tau‐PET signal. We explor… Show more
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