EXPERIMENTAL VITAMIN (A, B1, B2 and B COMPLEX) DEFICIENCY

Avian Thiamin Deficiency

“…Finally, one is led to the conclusion that the lesions which were observed in starved animals are of the same indefinite type, e.g., degeneration of myelin or demyelinization, as have been observed in thiamin deficient animals. With one exception (7), the clinical symptoms that were observed in thiamin deficient animals were distinct from anything observed in starved or otherwise deficient animals.…”

“…Other investigators (7)(8)(9)(10) found no, or few, degenerating nerve fibers in thiamin deficient rats, chicks, or other animals, and almost all have expressed the opinion that the symptoms of thiamin deficiency cannot be explained on the basis of observable pathological lesions. Non-specific vacuolation and shrinkage of nerve cells in various parts of the central nervous system have been seen frequently in both thiamin deficient and starved control animals, but in a recent review Vedder (11) pointed out that marked changes, the appearance of which suggested exhaustion, were to be found in ganglion cells of the nervous system, especially in the lumbosacral region of the spinal cord?…”

Avian Thiamin Deficiency

“…Finally, one is led to the conclusion that the lesions which were observed in starved animals are of the same indefinite type, e.g., degeneration of myelin or demyelinization, as have been observed in thiamin deficient animals. With one exception (7), the clinical symptoms that were observed in thiamin deficient animals were distinct from anything observed in starved or otherwise deficient animals.…”

“…Other investigators (7)(8)(9)(10) found no, or few, degenerating nerve fibers in thiamin deficient rats, chicks, or other animals, and almost all have expressed the opinion that the symptoms of thiamin deficiency cannot be explained on the basis of observable pathological lesions. Non-specific vacuolation and shrinkage of nerve cells in various parts of the central nervous system have been seen frequently in both thiamin deficient and starved control animals, but in a recent review Vedder (11) pointed out that marked changes, the appearance of which suggested exhaustion, were to be found in ganglion cells of the nervous system, especially in the lumbosacral region of the spinal cord?…”

Avian Thiamin Deficiency

“…Finally, one is led to the conclusion that the lesions which were observed in starved animals are of the same indefinite type, e.g., degeneration of myelin or demyelinization, as have been observed in thiamin deficient animals. With one exception (7), the clinical symptoms that were observed in thiamin deficient animals were distinct from anything observed in starved or otherwise deficient animals.…”

“…Other investigators (7)(8)(9)(10) found no, or few, degenerating nerve fibers in thiamin deficient rats, chicks, or other animals, and almost all have expressed the opinion that the symptoms of thiamin deficiency cannot be explained on the basis of observable pathological lesions. Non-specific vacuolation and shrinkage of nerve cells in various parts of the central nervous system have been seen frequently in both thiamin deficient and starved control animals, but in a recent review Vedder (11) pointed out that marked changes, the appearance of which suggested exhaustion, were to be found in ganglion cells of the nervous system, especially in the lumbosacral region of the spinal cord?…”

Avian Thiamin Deficiency

“…Finally, one is led to the conclusion that the lesions which were observed in starved animals are of the same indefinite type, e.g., degeneration of myelin or demyelinization, as have been observed in thiamin deficient animals. With one exception (7), the clinical symptoms that were observed in thiamin deficient animals were distinct from anything observed in starved or otherwise deficient animals.…”

“…Other investigators (7)(8)(9)(10) found no, or few, degenerating nerve fibers in thiamin deficient rats, chicks, or other animals, and almost all have expressed the opinion that the symptoms of thiamin deficiency cannot be explained on the basis of observable pathological lesions. Non-specific vacuolation and shrinkage of nerve cells in various parts of the central nervous system have been seen frequently in both thiamin deficient and starved control animals, but in a recent review Vedder (11) pointed out that marked changes, the appearance of which suggested exhaustion, were to be found in ganglion cells of the nervous system, especially in the lumbosacral region of the spinal cord?…”