Experimental Transmission of Scrapie to Rats

Chandler, R.L.; Fisher, Jacqueline

doi:10.1016/s0140-6736(63)90820-1

Cited by 57 publications

(25 citation statements)

References 8 publications

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“…All experiments were carried out with scrapie agent that was originally derived from the Compton 'drowsy goat' source (see Dickinson, 1976) and transmitted to mice by Chandler (1963). This material has been serially passaged intracerebrally (i.c.)…”

Section: Sources Ofscrapiementioning

confidence: 99%

“…Available evidence from studies of agent properties in mice of different sinc genotypes indicates that only a single agent is present after 2o mouse passes, designated ' Chandler' or 139A (Dickinson, 1976;and unpublished results). Brain homogenates from the 3rd mouse passage were used to transmit the disease to rats (Chandler & Fisher, 1963). After approximately 12 serial i.c.…”

Section: Sources Ofscrapiementioning

confidence: 99%

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Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

Kimberlin

Walker

1978

Journal of General Virology

239

184

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SUMMARYA previous paper (Kimberlin & Walker, 1977) described an experimental model of scrapie in hamsters in which the incubation period decreased progressively over the first 4 passages before becoming stable at the 5th and subsequent passes. Studies have been made of some of the agent strains present in brains taken from the 2nd, 3rd, 4th and 6th hamster passes. The results indicate the presence of at least two strains of agent at the 3rd passage level. One of these (43IK) is highly pathogenic for mice and the other (263K) has an extremely low pathogenicity for mice. However only one of these strains (263K) is present in hamster brain after the 6th serial passage. It is suggested that the 'adaptation' of scrapie to hamsters may involve the selection, from a mixture, of a single strain which is highly pathogenic for hamsters. The possibility of modification of the properties of agent strains on passage discussed.

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Section: Sources Ofscrapiementioning

confidence: 99%

Section: Sources Ofscrapiementioning

confidence: 99%

Evidence that the Transmission of One Source of Scrapie Agent to Hamsters Involves Separation of Agent Strains from a Mixture

Kimberlin

Walker

1978

Journal of General Virology

239

184

View full text Add to dashboard Cite

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“…In addition, infected cultures might provide a substrate on which infectivity could be titrated and agent-cell interactions studied. Several scrapie-infected cultures have been described (Clarke & Haig, 1970a;Clarke & Millson, 1976;Yanagihara et al, 1980;Markovits et al, 1981;Rubenstein et al, 1984;Cherednichenko et al, 1985). Of these the SMB culture (Clarke & Haig, 1970a) appears to offer the highest titre of agent.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Scrapie Infection in Mouse Neuroblastoma Cells

Race

Fadness

Chesebro

1987

Journal of General Virology

187

141

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“…There have also been reports of its natural occurrence on rare occasions in goats (Chelle, 1942;Mackay and Smith, ig6i). There are good reasons for regarding the causative agent as a virus since it is filtrable (Wilson, Anderson and Smith, 1950), appears to be capable of replication (Stamp,Brotherston,Ziotnik,Mackay and Smith,I 959), can be diluted out at an appropriate level, and can be transmitted serially by inoculation in sheep (Wilson et al, 1950), goats (Gordon and Pattison, ig), hamsters (Zlotnik, 1963), rats (Chandler and Fisher, 1963) or mice (Chandler, 1961) or by oral transmission to sheep and goats (Pattison and Milison, 1961b) or mice (Ziotnik and Rennie, 1962) or to goats by contact with sheep affected with natural scrapie (Stamp, 1962(Stamp, , 1965 or to mice by contact with affected mice (Dickinson, Mackay and Zlotnik, 1964;Pattison, 1964).…”

Section: Introductionmentioning

confidence: 99%