Experimental Tonography

The Tonographic Method for Measuring Aqueous Flow

“…They found the same value for outflow resistance determined tonographically and by perfusion both in the living and enucleated eye, and that it remained unchanged in the living eye regardless of whether the load was 5.5 g or more. That resistance is about the same in the living and dead eye has subsequently been confirmed by other investigators (Becker & Constant 1956;Fransois, Rabay & Neetens 1956 a, b). On the other hand, Weekers, Watillon & de Rudder (1956) found that outflow resistance increased, and experiments of Ericson ( 1 958) indicated that aqueous production decreased in the living human eye when the intra-ocular pressure was artificially increased.…”

The Tonographic Method for Measuring Aqueous Flow

“…They found the same value for outflow resistance determined tonographically and by perfusion both in the living and enucleated eye, and that it remained unchanged in the living eye regardless of whether the load was 5.5 g or more. That resistance is about the same in the living and dead eye has subsequently been confirmed by other investigators (Becker & Constant 1956;Fransois, Rabay & Neetens 1956 a, b). On the other hand, Weekers, Watillon & de Rudder (1956) found that outflow resistance increased, and experiments of Ericson ( 1 958) indicated that aqueous production decreased in the living human eye when the intra-ocular pressure was artificially increased.…”

The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24na in these fluids

“…The evidence adduced in favour of the claim that Diamox reduces the rate of secretion of aqueous humour may be briefly summarized. First, there is the observation that the time required for the appearance of intravenously injected fluorescein in the aqueous humour is increased (Linner & Friedenwald, quoted by Becker & Constant, 1955); secondly, it is argued that, because the intraocular pressure falls without a concurrent decrease in resistance to drainage, the rate of flow must fall; from the observed fall in intraocular pressure it is computed that the rate of flow must decrease by some 65% in rabbits (Becker & Constant, 1955) and 47 % in man (Weekers, Delmarcelle, Prijot & Lavergne, 1957). These estimates rely too much on the assumption that the venous pressure in the intrascleral plexus is unaltered, to be accepted readily.…”

Bioavailability of Acetazolamide Tablets

“…One subject showed poor absorption and had a flat plasma concentration-time curve with concentrations never exceeding 1.4 pg/ml after a 500-mg oral dose. Other investigators observed a lack of response in a patient given acetazolamide orally who responded to intramuscular therapy (5). Maren and Robinson (2) also reported variable acetazolamide absorption but only at high doses.…”

The Tonographic Method for Measuring Aqueous Flow

“…They found the same value for outflow resistance determined tonographically and by perfusion both in the living and enucleated eye, and that it remained unchanged in the living eye regardless of whether the load was 5.5 g or more. That resistance is about the same in the living and dead eye has subsequently been confirmed by other investigators (Becker & Constant 1956;Fransois, Rabay & Neetens 1956 a, b). On the other hand, Weekers, Watillon & de Rudder (1956) found that outflow resistance increased, and experiments of Ericson ( 1 958) indicated that aqueous production decreased in the living human eye when the intra-ocular pressure was artificially increased.…”

The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24na in these fluids

“…The evidence adduced in favour of the claim that Diamox reduces the rate of secretion of aqueous humour may be briefly summarized. First, there is the observation that the time required for the appearance of intravenously injected fluorescein in the aqueous humour is increased (Linner & Friedenwald, quoted by Becker & Constant, 1955); secondly, it is argued that, because the intraocular pressure falls without a concurrent decrease in resistance to drainage, the rate of flow must fall; from the observed fall in intraocular pressure it is computed that the rate of flow must decrease by some 65% in rabbits (Becker & Constant, 1955) and 47 % in man (Weekers, Delmarcelle, Prijot & Lavergne, 1957). These estimates rely too much on the assumption that the venous pressure in the intrascleral plexus is unaltered, to be accepted readily.…”

Bioavailability of Acetazolamide Tablets

“…One subject showed poor absorption and had a flat plasma concentration-time curve with concentrations never exceeding 1.4 pg/ml after a 500-mg oral dose. Other investigators observed a lack of response in a patient given acetazolamide orally who responded to intramuscular therapy (5). Maren and Robinson (2) also reported variable acetazolamide absorption but only at high doses.…”

The Tonographic Method for Measuring Aqueous Flow

“…They found the same value for outflow resistance determined tonographically and by perfusion both in the living and enucleated eye, and that it remained unchanged in the living eye regardless of whether the load was 5.5 g or more. That resistance is about the same in the living and dead eye has subsequently been confirmed by other investigators (Becker & Constant 1956;Fransois, Rabay & Neetens 1956 a, b). On the other hand, Weekers, Watillon & de Rudder (1956) found that outflow resistance increased, and experiments of Ericson ( 1 958) indicated that aqueous production decreased in the living human eye when the intra-ocular pressure was artificially increased.…”

The effect of acetazoleamide on the chemical composition of the aqueous humour and cerebrospinal fluid of some mammalian species and on the rate of turnover of 24na in these fluids

“…The evidence adduced in favour of the claim that Diamox reduces the rate of secretion of aqueous humour may be briefly summarized. First, there is the observation that the time required for the appearance of intravenously injected fluorescein in the aqueous humour is increased (Linner & Friedenwald, quoted by Becker & Constant, 1955); secondly, it is argued that, because the intraocular pressure falls without a concurrent decrease in resistance to drainage, the rate of flow must fall; from the observed fall in intraocular pressure it is computed that the rate of flow must decrease by some 65% in rabbits (Becker & Constant, 1955) and 47 % in man (Weekers, Delmarcelle, Prijot & Lavergne, 1957). These estimates rely too much on the assumption that the venous pressure in the intrascleral plexus is unaltered, to be accepted readily.…”

Bioavailability of Acetazolamide Tablets

“…One subject showed poor absorption and had a flat plasma concentration-time curve with concentrations never exceeding 1.4 pg/ml after a 500-mg oral dose. Other investigators observed a lack of response in a patient given acetazolamide orally who responded to intramuscular therapy (5). Maren and Robinson (2) also reported variable acetazolamide absorption but only at high doses.…”