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Cited by 3 publications
(2 citation statements)
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“…This encouraged us to explore PENAO in this combination. We demonstrated that HOS cells displayed a reasonable inhibition in mitochondrial activity (decreased OCR) after PENAO single agent treatment, which was similarly observed in glioblastoma and diffuse intrinsic pontine glioma [50,52,71,72]. Our results also showed a significant reduction of OCR and increase of ECAR in HOS cells treated with PENAO plus gefitinib when compared to single agents.…”
Section: Discussionsupporting
confidence: 78%
See 1 more Smart Citation
“…This encouraged us to explore PENAO in this combination. We demonstrated that HOS cells displayed a reasonable inhibition in mitochondrial activity (decreased OCR) after PENAO single agent treatment, which was similarly observed in glioblastoma and diffuse intrinsic pontine glioma [50,52,71,72]. Our results also showed a significant reduction of OCR and increase of ECAR in HOS cells treated with PENAO plus gefitinib when compared to single agents.…”
Section: Discussionsupporting
confidence: 78%
“…PENAO's trivalent arsenical moiety cross-links unpaired cysteine residues Cys 57 and Cys 257 located on the peptide loop of ANT that protrude into the matrix [39]. This leads to metabolic perturbation, swelling of the inner mitochondrial membrane, rupture of the outer membrane and cell death [38,40,52]. PENAO completed a phase I trial in patients with solid tumours refractory to standard treatment (trial ID: ANCTRN12612000908831).…”
Section: Research Papermentioning
confidence: 99%