Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways

LIU, Qiyun; FU, Qian; Du, Jia; LIU, Xiaohui

doi:10.1590/fst.31121

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Additionally, the inhibitory effects of allicin on cardiac hypertrophy in rats can also be mediated by the inhibition of apoptosis and the stimulation of angiogenesis [ 95 ]. In cell cultures of cardiomyocyte allicin increase the expression of PPARα, PPARγ, and Bcl-2, and downregulate Bax, Fas, and Fax-L, these effects were induced by Angiotensin II stimulation and suggested that allicin can regulate apoptosis and ventricular remodeling [ 96 ].…”

Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning

confidence: 99%

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Sánchez-Gloria

Arellano‐Buendía

Juárez-Rojas

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) are a group of diseases in which the common denominator is the affection of blood vessels, heart tissue, and heart rhythm. The genesis of CVD is complex and multifactorial; therefore, approaches are often based on multidisciplinary management and more than one drug is used to achieve the optimal control of risk factors (dyslipidemia, hypertension, hypertrophy, oxidative stress, endothelial dysfunction, inflammation). In this context, allicin, a sulfur compound naturally derived from garlic, has shown beneficial effects on several cardiovascular risk factors through the modulation of cellular mechanisms and signaling pathways. Effective pharmacological treatments for CVD or its risk factors have not been developed or are unknown in clinical practice. Thus, this work aimed to review the cellular mechanisms through which allicin exerts its therapeutic effects and to show why it could be a therapeutic option for the prevention or treatment of CVD and its risk factors.

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Section: Effects Of Allicin On Cardiovascular Risk Factorsmentioning

confidence: 99%

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Sánchez-Gloria

Arellano‐Buendía

Juárez-Rojas

et al. 2022

IJMS

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“…Garlic has a long history of use as a plant for both medicine and food. It has been found to be beneficial in adjuvant treatment of tumors, heart diseases, metabolic diseases, anti-inflammatory and anti-bacterial (Arslaner, 2020;Liu et al, 2022). It has been developed into a variety of products, such as Laba garlic, black garlic, etc (Lishianawati et al, 2022;Setiyoningrum et al, 2021;Gao et al, 2019a).…”

Section: Synthesis Of Hydrogels Based On Nanocellulose From Garlic St...mentioning

confidence: 99%

Synthesis of hydrogels based on nanocellulose from garlic straw and regulating the release of allicin and its cytotoxicity

GAO,

JIA,

CHEN

et al. 2022

Food Sci. Technol

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Allicin is an organosulfur compound found in garlic, which is well known for their anticancer properties, however, its application was limited due to its instability towards light, heat, and alkaline conditions. In order to improve the bioavailability and stability of allicin, allicin was loaded into the garlic straw nanocellulose hydrogels and its physiochemical properties and toxicity towards normal hepatocyte cells (L02) and cancerous cells (HepG2) were evaluated. Initially, garlic straw was used as raw material to extract cellulose (GSC) and the garlic straw nanocellulose (GSNC) with a particle size of 168.0 ± 0.65 nm was prepared. Then, GSNC hydrogels were further prepared. The swelling rate of hydrogels in various medium was also determined. Finally, allicin was loaded into the hydrogels. The results showed that GSNC hydrogels had the porous structure, high pH sensitivity and the swelling rate in simulated intestinal fluid was 3054.24%. The drug loading capacity of allicin was 166.4 mg/g and the entrapment efficiency of allicin in GSNC hydrogel was 83.20%. The release rate of allicin-GSNC hydrogel was the highest in simulated intestinal fluid, and it could release allicin slowly. Moreover, the allicin-GNSC hydrogel were non-toxic towards L02 cells and had obvious toxicity towards HepG2 cells.

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“…Garlic, renowned for its intriguing nature, has been utilized both as a culinary ingredient and for medicinal purposes. It is recognized as being valuable in tumor treatments, metabolic diseases, heart diseases, and it has anti-bacterial, and anti-inflammatory properties [ 33 , 34 ]. In the garlic cultivation sector, garlic straws and peels are well recognized as waste; simply, small amounts are used as food and most are cooked [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Garlic Cellulosic Powders with Immobilized AgO and CuO Nanoparticles: Preparation, Characterization of the Nanocomposites, and Application to the Catalytic Degradation of Azo Dyes

Sebeia,

Jabli,

Sonsudin

2024

Polymers

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Nanomaterials have attracted specific consideration due to their specific characteristics and uses in several promising fields. In the present study, Chondrilla juncea was employed as a biological extract to facilitate the reduction of copper and silver ions within garlic peel powders. The resulting garlic-CuO and garlic-AgO nanocomposites were characterized using several analytical methods including FTIR, TGA/DTG, SEM, TEM, and XRD analyses. The garlic peel exhibited a rough surface. The nanoparticles were evenly dispersed across its surface. The incorporation of CuO and AgO nanoparticles affected the crystal structure of garlic peel. The establishment of CuO and AgO nanoparticles was evidenced by the highest residual mass values observed for the prepared nanocomposites. The thermogravimetric analysis showed that the prepared nanocomposites had lower thermal stability compared with garlic peel powders. The prepared nanocomposites were used for catalytic degradation of naphthol blue black B and calmagite. The decolorization process depended on the quantity of H2O2, initial concentration of azo dyes, duration of contact, and temperature of the bath. The calculated activation energy (Ea) values for the garlic-CuO nanocomposites were found to be 18.44 kJ mol−1 and 23.28 kJ mol−1 for calmagite and naphthol solutions, respectively. However, those calculated for garlic-AgO nanocomposites were found to be 50.01 kJ mol−1 and 12.44 kJ mol−1 for calmagite and naphthol, respectively.

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Experimental study on the role and mechanism of Allicin in ventricular remodeling through PPARα and PPARγ signaling pathways

Cited by 3 publications

References 12 publications

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Cellular Mechanisms Underlying the Cardioprotective Role of Allicin on Cardiovascular Diseases

Synthesis of hydrogels based on nanocellulose from garlic straw and regulating the release of allicin and its cytotoxicity

Garlic Cellulosic Powders with Immobilized AgO and CuO Nanoparticles: Preparation, Characterization of the Nanocomposites, and Application to the Catalytic Degradation of Azo Dyes

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