Experimental study of peritoneal blood flow and insufflation pressure during laparoscopy

Brundell, S.; Tsopelas, Chris; Chatterton, Barry E.; Touloumtzoglou, Joanna; Hewett, Peter

doi:10.1046/j.1365-2168.2002.02071.x

Cited by 26 publications

(23 citation statements)

References 31 publications

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“…The current study shows, in accordance with a recent study [2], that insufflation of CO 2 into the abdominal cavity of pigs is associated with a substantial increase in blood flow in the peritoneum. Our findings also support the view that such vasodilation is caused by properties related to CO 2 itself, and not to changed central hemodynamics or activation of neural reflex mechanisms potentially elicited by increased intraabdominal pressure.…”

Section: Discussionsupporting

confidence: 79%

Effect of carbon dioxide pneumoperitoneum on tissue blood flow in the peritoneum, rectus abdominis, and diaphragm muscles

et al. 2003

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Section: Discussionsupporting

confidence: 79%

Effect of carbon dioxide pneumoperitoneum on tissue blood flow in the peritoneum, rectus abdominis, and diaphragm muscles

et al. 2003

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“…Recent studies reported higher ratios of tumour seeding-both peritoneal and at port sites-in laparoscopic surgeries 3,8,16,17 . Exposure to a pneumoperitoneum-laparoscopic environment is shown to enhance the invasive capacity of colonic adenocarcinomas by a protease-determined pathway 8 .…”

Section: Discussionmentioning

confidence: 99%

“…Also, blood flow within the peritoneum may be influenced by insufflation with carbon dioxide. Such hyperemia could increase the propensity of implanted tumour cells to metastasize in these sites 16 . Tumour cells released into the operative field can therefore be made increasingly aggressive by a laparoscopic operative environment and can thus contribute to disease dissemination 8 .…”

Section: Discussionmentioning

confidence: 99%

Peritoneal Seeding and Subsequent Progression of Mantle Cell Lymphoma after Splenectomy for Debulking

et al. 2010

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BackgroundPeritoneal seeding after abdominal surgery is a well known route of metastasis in intra-abdominal solid tumours. Direct mechanical contamination, local peritoneal trauma and subsequent inflammation, postoperative immunosuppression, and laparoscopic surgery are the proposed predisposing factors for this type of metastasis. These factors probably result in enhanced adhesion or growth of tumour cells. However, this route of metastasis has not yet been reported for lymphomas. Here, we report the first case of peritoneal seeding of lymphoma cells after an abdominal surgery. Case DescriptionA 47-year-old man with mantle cell lymphoma had ascites because of infiltration of the liver. He underwent debulking splenectomy. The postoperative ascites cytology and control abdominal computed tomography imaging both confirmed peritoneal involvement and lymphoma progression. Demonstration of negative peritoneal involvement before surgery and close timing of peritoneal involvement after splenectomy suggested to us that the debulking surgery was the main cause of peritoneal seeding of lymphoma cells in our case. ConclusionsFactors similar to those in solid tumour seeding may also be valid for lymphomas. Peritoneal seeding and consequent disease progression may be a potential complication of abdominal surgery in lymphoma with extensive intra-abdominal involvement.

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“…23 Two cytosolic enzymes ALT and AST are mostly used to evaluate hepatic function. In this study both the ALT and AST revealed no statistically significant changes among the different groups in respect to different time intervals.…”

Section: Effect Of Different Carbon Dioxide Pressure Gradients In Capmentioning

confidence: 99%

Effect of Different Carbon Dioxide Pressure Gradients in Capnoperitoneum for Laparoscopic Examination in Dogs

Maiti¹,

Dutta²,

Varshney³

et al. 2013

WJOLS

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Eighteen female mongrel bitches, equally divided into three groups (A, B and C) were subjected to CO 2 insufflation at 6, 10 and 14 mm Hg pressure gradient respectively to study the physiological changes of capnoperitoneum during laparoscopy. Optimum visualization of internal organs during laparoscopy was achieved at 10 and 14 mm Hg of CO 2 pressure gradient. The physiological effects were more pronounced at 14 mm Hg of CO 2 pressure gradient. Marked increase of respiration rate in correlation with increased pCO 2 and decreased pO 2 was observed in the group C. Bradyarrhythmia was observed in all three groups, however, myocardial ischemia or hypoxia as reflected through S-T segment depression and elevation was more pronounced in 14 mm Hg of CO 2 pressure gradient (group C). Alteration of liver function was within the physiological range in the animals of all the three groups. Physiological stress was remained significantly higher with 14 mm Hg intra-abdominal pressure. In conclusion, 10 mm Hg of CO 2 was found most suitable pressure gradient for laparoscopic examination in dogs.

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Experimental study of peritoneal blood flow and insufflation pressure during laparoscopy

Abstract: These data suggest that blood flow within the peritoneum is influenced by insufflation with carbon dioxide. It is conceivable that such hyperaemia could increase the propensity for implanted tumour cells to metastasize in these sites following laparoscopy.

Cited by 26 publications

References 31 publications

Effect of carbon dioxide pneumoperitoneum on tissue blood flow in the peritoneum, rectus abdominis, and diaphragm muscles

Effect of carbon dioxide pneumoperitoneum on tissue blood flow in the peritoneum, rectus abdominis, and diaphragm muscles

Peritoneal Seeding and Subsequent Progression of Mantle Cell Lymphoma after Splenectomy for Debulking

Effect of Different Carbon Dioxide Pressure Gradients in Capnoperitoneum for Laparoscopic Examination in Dogs

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