Experimental Study of Bioactive Polyurethane Sponge as an Artificial Trachea

Yanagi, Masakazu; Kishida, Akio; Shimotakahara, T; Matsumoto, Hajime; Nishijima, Hiroo; Akashi, Mitsuru; Aikou, Takashi

doi:10.1097/00002480-199407000-00032

Cited by 18 publications

(16 citation statements)

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“…After subcutaneous implantation, the constructs resulted very similar to native tracheal cartilage, thus effectively promoting cartilage regeneration in vivo . PU sponges conditioned with collagen, RGD, fibronectin or apatite and implanted as tracheal patches (8 mm × 8 mm), showed that the latter two agents favored epithelialization, tissue ingrowth and lower inflammatory response . Regeneration of tracheal epithelium was assessed in vivo using a collagen vitrigel scaffold characterized by a smooth surface to facilitate epithelial cell migration after implantation .…”

Section: Tracheamentioning

confidence: 99%

Are synthetic scaffolds suitable for the development of clinical tissue‐engineered tubular organs?

Gaudio

Baiguera

Ajalloueian

et al. 2013

J Biomedical Materials Res

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Transplantation of tissues and organs is currently the only available treatment for patients with end‐stage diseases. However, its feasibility is limited by the chronic shortage of suitable donors, the need for life‐long immunosuppression, and by socioeconomical and religious concerns. Recently, tissue engineering has garnered interest as a means to generate cell‐seeded three‐dimensional scaffolds that could replace diseased organs without requiring immunosuppression. Using a regenerative approach, scaffolds made by synthetic, nonimmunogenic, and biocompatible materials have been developed and successfully clinically implanted. This strategy, based on a viable and ready‐to‐use bioengineered scaffold, able to promote novel tissue formation, favoring cell adhesion and proliferation, could become a reliable alternative to allotransplatation in the next future. In this article, tissue‐engineered synthetic substitutes for tubular organs (such as trachea, esophagus, bile ducts, and bowel) are reviewed, including a discussion on their morphological and functional properties. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 2427–2447, 2014

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Section: Tracheamentioning

confidence: 99%

Are synthetic scaffolds suitable for the development of clinical tissue‐engineered tubular organs?

Gaudio

Baiguera

Ajalloueian

et al. 2013

J Biomedical Materials Res

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“…These applications include vascular prostheses [9,10], arti cial hearts [2,11], catheters [12] and arti cial tracheae [13]. However, like other synthetic materials, they are generally thrombogenic on exposure to blood.…”

Section: Introductionmentioning

confidence: 99%

Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization

Jun¹,

West²

2004

Journal of Biomaterials Science, Polymer Edition

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Polyurethanes have been investigated for use as vascular grafts due to their excellent mechanical properties and relatively good biocompatibility. However, poor retention of endothelial cells and thrombogenicity in vivo remain problematic for vascular graft applications. The peptide YIGSR has been shown to increase endothelial cell adhesion but not attachment of platelets, suggesting its possible utility for vascular graft applications. In this study, a bioactive polyurethaneurea has been synthesized by incorporating GGGYIGSRGGGK peptide sequences into the polymer backbone. Successful incorporation of the peptides was confirmed by NMR, contact angle measurement and ESCA. Uniform distribution of peptides on the surface was observed using a fluorescent probe capable of reacting with tyrosine residues on the peptides. Hard segment domains were visualized using tapping mode AFM. Endothelial cell adhesion, spreading, proliferation, migration and extra-cellular matrix production were improved on bioactive polyurethaneurea compared to control polyurethaneurea. Competitive inhibition of endothelial cell attachment and spreading by soluble YIGSR peptides indicated that cell adhesion and spreading were specifically mediated by YIGSR-sensitive cell adhesion receptor, not just by changed surface properties. There was no significant difference in the number of adherent platelets. Therefore, this bioactive polyurethanurea may improve vascular graft endothelialization without increasing thrombogenicity.

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“…Another composite culture study compared coating a polyurethane sponge with collagen, fibronectin, RGD, or apatite. 105 Some inflammation occurred in the RGD constructs, and the apatite and fibronectin scaffolds appeared to perform better in dog tracheas. All constructs were complicated by sputum absorption.…”

Section: Combination Of Materialsmentioning

confidence: 95%

Overview of Tracheal Tissue Engineering: Clinical Need Drives the Laboratory Approach

2011

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Breathing is a natural function that most of us do not even think about, but for those who suffer from disease or damage of the trachea, the obstruction of breathing can mean severe restrictions to quality of life or may even be fatal. Replacement and reconstruction of the trachea is one of the most difficult procedures in otolaryngology/head and neck surgery, and also one of the most vital. Previous reviews have focused primarily on clinical perspectives or instead on engineering strategies. However, the current review endeavors to bridge this gap by evaluating engineering approaches in a practical clinical context. For example, although contemporary approaches often include in vitro bioreactor pre-culture, or sub-cutaneous in vivo conditioning, the limitations they present in terms of regulatory approval, cost, additional surgery, and/or risk of infection challenge engineers to develop the next generation of biodegradable/resorbable biomaterials that can be directly implanted in situ. Essentially, the functionality of the replacement is the most important requirement. It must be the correct shape and size, achieve an airtight fit, resist collapse as it is replaced by new tissue, and be non-immunogenic. As we look to the future, there will be no one-size-fits-all solution.

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Experimental Study of Bioactive Polyurethane Sponge as an Artificial Trachea

Cited by 18 publications

References 0 publications

Are synthetic scaffolds suitable for the development of clinical tissue‐engineered tubular organs?

Are synthetic scaffolds suitable for the development of clinical tissue‐engineered tubular organs?

Development of a YIGSR-peptide-modified polyurethaneurea to enhance endothelialization

Overview of Tracheal Tissue Engineering: Clinical Need Drives the Laboratory Approach

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