2020
DOI: 10.1016/j.bbi.2019.10.012
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Abstract: HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des labor… Show more

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Cited by 29 publications
(38 citation statements)
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“…Although BBB breakdown has been proposed to play a role in brain dysfunction during sepsis, 44 our previous work using CLP followed by brain imaging and histology, did not show increased perivascular diffusion of IgG, except in the fimbria. 15 As this was at variance with numerous previous studies indicating BBB breakdown after CLP, but that did not use imaging, [45][46][47][48][49][50] we wondered if MRI under isoflurane anesthesia played a role in our previous finding.…”
Section: Discussionmentioning
confidence: 69%
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“…Although BBB breakdown has been proposed to play a role in brain dysfunction during sepsis, 44 our previous work using CLP followed by brain imaging and histology, did not show increased perivascular diffusion of IgG, except in the fimbria. 15 As this was at variance with numerous previous studies indicating BBB breakdown after CLP, but that did not use imaging, [45][46][47][48][49][50] we wondered if MRI under isoflurane anesthesia played a role in our previous finding.…”
Section: Discussionmentioning
confidence: 69%
“…Respiration was assessed with a ventral pressure sensor and heart rate recorded using an MRI compatible electrode. 15 Isoflurane concentration was adapted to maintain respiratory rate around 50 per minute (±10).…”
Section: Surgery Behavioral Evaluation and Magnetic Resonance Imagingmentioning
confidence: 99%
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“…Notably, a key determinant of the development of SAE is the damage of the BBB ( 47 ), which protects the CNS from pathogens and toxicity ( 48 ). BBB dysfunction in sepsis and its association with clinical features (such as systemic inflammation) has been reported on ( 49 ).…”
Section: Discussionmentioning
confidence: 99%
“…Absolut (n) Relativ (%) Diskutiert werden u. a. auch sekundäre Inflammationsreaktionen, die über aktivierte Astroglia eine direkte neuronale Schädigung hervorrufen können [5,6]. Bisher wurden verschiedene diagnostische Ansätze, wie elektrophysiologische Verfahren (Elektroenzephalografie, EEG), zerebrale Bildgebungen (kranielle Computertomographie, cCT; kranielle Magnetresonanztomographie, cMRT), Messung von zerebraler Perfusion und Oxygenierung (transkranielle Dopplersonographie, TCD; Nahinfrarotspektroskopie, NIRS) sowie Biomarker in Blut oder Liquor bei Intensivpatienten mit SAE untersucht [1,5,[7][8][9][10].…”
Section: Tab 1 Demografische Basisdatenunclassified