Experimental Retinal Detachment

Choroidal thickness and vascular density after rhegmatogenous retinal detachment

“…During RRD, the liquefied vitreous and subsequently aqueous humour flows through the retinal breaks into the subretinal space (Pederson & Cantrill, 1984). It has been estimated that the RPE in an average eye can transport up to 3.5 mL of fluid per day, which equals 50% of the vitreous volume (Quintyn & Brasseur, 2004).…”

Choroidal thickness and vascular density after rhegmatogenous retinal detachment

“…During RRD, the liquefied vitreous and subsequently aqueous humour flows through the retinal breaks into the subretinal space (Pederson & Cantrill, 1984). It has been estimated that the RPE in an average eye can transport up to 3.5 mL of fluid per day, which equals 50% of the vitreous volume (Quintyn & Brasseur, 2004).…”

Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function

“…2 It is well-accepted that the RPE fluid pump is the main mechanism for apposition and retinal reattachment in both the physiologic state and in PR, respec- tively. 8,9 Transepithelial water movement across RPE monolayers is facilitated by aquaporin-1 channels experimentally in human RPE, but little is known about the role of melanin in patients with OA who develop subretinal fluid as a consequence of RRD. 10 Previous studies have demonstrated a number of abnormalities in OA, including insufficient L-DOPA levels in the RPE, which results in a tendency for unregulated proliferation of RPE cells.…”

Effect of Retinal Permeability, Diffusivity, and Aqueous Humor Hydrodynamics on Pharmacokinetics of Drugs in the Eye

“…Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers. 5,31,32 Although retinal-permeability changes are both owing to the physicochemical properties of drugs and the pathophysiologic conditions, this study assumed the retinal per-meability only as a function of the physicochemical property of the drug. The diseased condition was taken care of by the elevated vitreous outflow condition (F10).…”

“…The main limitations of this study were that the effect of local drug metabolism, the drug binding to intraocular proteins, and the influence of the location of the site of IJ and IP have not been evaluated. Also, the phrase "diseased condition" could imply the change in retinal permeability, abnormal vitreous outflow, 14,31 or both. Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers.…”

Choroidal thickness and vascular density after rhegmatogenous retinal detachment

“…During RRD, the liquefied vitreous and subsequently aqueous humour flows through the retinal breaks into the subretinal space (Pederson & Cantrill, 1984). It has been estimated that the RPE in an average eye can transport up to 3.5 mL of fluid per day, which equals 50% of the vitreous volume (Quintyn & Brasseur, 2004).…”

Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function

“…2 It is well-accepted that the RPE fluid pump is the main mechanism for apposition and retinal reattachment in both the physiologic state and in PR, respec- tively. 8,9 Transepithelial water movement across RPE monolayers is facilitated by aquaporin-1 channels experimentally in human RPE, but little is known about the role of melanin in patients with OA who develop subretinal fluid as a consequence of RRD. 10 Previous studies have demonstrated a number of abnormalities in OA, including insufficient L-DOPA levels in the RPE, which results in a tendency for unregulated proliferation of RPE cells.…”

Effect of Retinal Permeability, Diffusivity, and Aqueous Humor Hydrodynamics on Pharmacokinetics of Drugs in the Eye

“…Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers. 5,31,32 Although retinal-permeability changes are both owing to the physicochemical properties of drugs and the pathophysiologic conditions, this study assumed the retinal per-meability only as a function of the physicochemical property of the drug. The diseased condition was taken care of by the elevated vitreous outflow condition (F10).…”

“…The main limitations of this study were that the effect of local drug metabolism, the drug binding to intraocular proteins, and the influence of the location of the site of IJ and IP have not been evaluated. Also, the phrase "diseased condition" could imply the change in retinal permeability, abnormal vitreous outflow, 14,31 or both. Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers.…”

Choroidal thickness and vascular density after rhegmatogenous retinal detachment

“…During RRD, the liquefied vitreous and subsequently aqueous humour flows through the retinal breaks into the subretinal space (Pederson & Cantrill, 1984). It has been estimated that the RPE in an average eye can transport up to 3.5 mL of fluid per day, which equals 50% of the vitreous volume (Quintyn & Brasseur, 2004).…”

Failed Pneumatic Retinopexy for Rhegmatogenous Retinal Detachment Repair in Ocular Albinism: Clues to the Role of Melanin in Retinal Pigment Epithelium Pump Function

“…2 It is well-accepted that the RPE fluid pump is the main mechanism for apposition and retinal reattachment in both the physiologic state and in PR, respec- tively. 8,9 Transepithelial water movement across RPE monolayers is facilitated by aquaporin-1 channels experimentally in human RPE, but little is known about the role of melanin in patients with OA who develop subretinal fluid as a consequence of RRD. 10 Previous studies have demonstrated a number of abnormalities in OA, including insufficient L-DOPA levels in the RPE, which results in a tendency for unregulated proliferation of RPE cells.…”

Effect of Retinal Permeability, Diffusivity, and Aqueous Humor Hydrodynamics on Pharmacokinetics of Drugs in the Eye

“…Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers. 5,31,32 Although retinal-permeability changes are both owing to the physicochemical properties of drugs and the pathophysiologic conditions, this study assumed the retinal per-meability only as a function of the physicochemical property of the drug. The diseased condition was taken care of by the elevated vitreous outflow condition (F10).…”

“…The main limitations of this study were that the effect of local drug metabolism, the drug binding to intraocular proteins, and the influence of the location of the site of IJ and IP have not been evaluated. Also, the phrase "diseased condition" could imply the change in retinal permeability, abnormal vitreous outflow, 14,31 or both. Disruption of retina owing to a large number of retinal diseases simultaneously alters the pattern of drug movement and its distribution inside the ocular chambers.…”