Experimental Pseudomonas Keratitis

Topical Tobramycin Therapy of Experimental Pseudomonas Keratitis

“…2.08 ± 1.07(6) 1.03 ± 0.51 (6) . Under conditions of the experi¬ ment, topical therapy with benzal¬ konium chloride, cocaine, and dimeth¬ yl sulfoxide did not significantly improve results of topical therapy with tobramycin.…”

Topical Tobramycin Therapy of Experimental Pseudomonas Keratitis

“…2.08 ± 1.07(6) 1.03 ± 0.51 (6) . Under conditions of the experi¬ ment, topical therapy with benzal¬ konium chloride, cocaine, and dimeth¬ yl sulfoxide did not significantly improve results of topical therapy with tobramycin.…”

Topical immunotherapy for pseudomonas keratitis in rabbits: use of antilipopolysaccharide plasma.

“…In another study, with carbenicillin and gentamicin, it was found that the keratitis continued to worsen for up to seven days before improvement was noted. 16 In a different experimental model anti-LPS has already been observed to be more effective therapeutically than gentamicin. In our studywith anti-LPS, improvement commenced within three days.…”

Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs

“…Because the severity of the corneal injury is often not uniform and because of the variability inherent in the topical application of bacterial suspensions, the severity of the keratitis in this model is unpredictable. In one recent study, untreated eyes had milder lesions than eyes treated with antibiotics (1). In another, five of 25 infected eyes treated only with saline had either no abnormalities or minimal lesions (9).…”

Topical Tobramycin Therapy of Experimental Pseudomonas Keratitis

“…2.08 ± 1.07(6) 1.03 ± 0.51 (6) . Under conditions of the experi¬ ment, topical therapy with benzal¬ konium chloride, cocaine, and dimeth¬ yl sulfoxide did not significantly improve results of topical therapy with tobramycin.…”

Topical immunotherapy for pseudomonas keratitis in rabbits: use of antilipopolysaccharide plasma.

“…In another study, with carbenicillin and gentamicin, it was found that the keratitis continued to worsen for up to seven days before improvement was noted. 16 In a different experimental model anti-LPS has already been observed to be more effective therapeutically than gentamicin. In our studywith anti-LPS, improvement commenced within three days.…”

Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs

“…Because the severity of the corneal injury is often not uniform and because of the variability inherent in the topical application of bacterial suspensions, the severity of the keratitis in this model is unpredictable. In one recent study, untreated eyes had milder lesions than eyes treated with antibiotics (1). In another, five of 25 infected eyes treated only with saline had either no abnormalities or minimal lesions (9).…”

Topical Tobramycin Therapy of Experimental Pseudomonas Keratitis

“…2.08 ± 1.07(6) 1.03 ± 0.51 (6) . Under conditions of the experi¬ ment, topical therapy with benzal¬ konium chloride, cocaine, and dimeth¬ yl sulfoxide did not significantly improve results of topical therapy with tobramycin.…”

Topical immunotherapy for pseudomonas keratitis in rabbits: use of antilipopolysaccharide plasma.

“…In another study, with carbenicillin and gentamicin, it was found that the keratitis continued to worsen for up to seven days before improvement was noted. 16 In a different experimental model anti-LPS has already been observed to be more effective therapeutically than gentamicin. In our studywith anti-LPS, improvement commenced within three days.…”

Experimental Keratitis Due to Pseudomonas aeruginosa: Model for Evaluation of Antimicrobial Drugs

“…Because the severity of the corneal injury is often not uniform and because of the variability inherent in the topical application of bacterial suspensions, the severity of the keratitis in this model is unpredictable. In one recent study, untreated eyes had milder lesions than eyes treated with antibiotics (1). In another, five of 25 infected eyes treated only with saline had either no abnormalities or minimal lesions (9).…”