Experimental Physiological Studies With Lysergic Acid Diethylamide (Lsd-25)

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

“…Similar findings were reported in early studies in the 1950s (73)(74)(75)(76)(77). In contrast, LSD (200µg, orally) did not alter diastolic or systolic blood pressure or heart rate in a recent study in eight patients with different chronic life-threatening illnesses (11).…”

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

“…Similar findings were reported in early studies in the 1950s (73)(74)(75)(76)(77). In contrast, LSD (200µg, orally) did not alter diastolic or systolic blood pressure or heart rate in a recent study in eight patients with different chronic life-threatening illnesses (11).…”

The Occurrence of Depersonalization Phenomena under LSD

“…A nxiety and euphoria were in this scries of bo th norm als and p a tie n ts m ore com m only in duced th a n depression. The m ood changes were in fact sim ilar to those reported b y Stoll [1947], Iloch et al [1952], Forrer and Goldner [1951], DeShon et al [1952], Liddell and Weil-Malherbe [1953] and Savage [1952]. Sloane and Doust [1954] considered th a t th e m ood changes seem ed to be dependent upon th e affective sta te of the su b ject, prior to the ad m in istratio n of lysergic acid.…”

The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

“…LSD can cause significant autonomic effects, including blood pressure (systolic and diastolic), heart rate and body temperature. Early studies also reported similar conclusions in the 1950s (Belleville et al., 1956; Dimascio et al., 1957; Forrer & Goldner, 1951; Kornetsky, 1957; Sokoloff et al., 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life‐threatening after the administration of 200 mcg LSD orally.…”

“…Early studies also reported similar conclusions in the 1950s F I G U R E 6 Safety endpoints of autonomic effects for LSD of any drug dose compared with placebo. LSD: lysergic acid diethylamide, SD: standard deviation, CI: confidence interval, IV: inverse variance methods (Belleville et al, 1956;Dimascio et al, 1957;Forrer & Goldner, 1951;Kornetsky, 1957;Sokoloff et al, 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life-threatening after the administration of 200 mcg LSD orally.…”

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

“…Similar findings were reported in early studies in the 1950s (73)(74)(75)(76)(77). In contrast, LSD (200µg, orally) did not alter diastolic or systolic blood pressure or heart rate in a recent study in eight patients with different chronic life-threatening illnesses (11).…”

The Occurrence of Depersonalization Phenomena under LSD

“…A nxiety and euphoria were in this scries of bo th norm als and p a tie n ts m ore com m only in duced th a n depression. The m ood changes were in fact sim ilar to those reported b y Stoll [1947], Iloch et al [1952], Forrer and Goldner [1951], DeShon et al [1952], Liddell and Weil-Malherbe [1953] and Savage [1952]. Sloane and Doust [1954] considered th a t th e m ood changes seem ed to be dependent upon th e affective sta te of the su b ject, prior to the ad m in istratio n of lysergic acid.…”

The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

“…LSD can cause significant autonomic effects, including blood pressure (systolic and diastolic), heart rate and body temperature. Early studies also reported similar conclusions in the 1950s (Belleville et al., 1956; Dimascio et al., 1957; Forrer & Goldner, 1951; Kornetsky, 1957; Sokoloff et al., 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life‐threatening after the administration of 200 mcg LSD orally.…”

“…Early studies also reported similar conclusions in the 1950s F I G U R E 6 Safety endpoints of autonomic effects for LSD of any drug dose compared with placebo. LSD: lysergic acid diethylamide, SD: standard deviation, CI: confidence interval, IV: inverse variance methods (Belleville et al, 1956;Dimascio et al, 1957;Forrer & Goldner, 1951;Kornetsky, 1957;Sokoloff et al, 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life-threatening after the administration of 200 mcg LSD orally.…”

Acute Effects of Lysergic Acid Diethylamide in Healthy Subjects

“…Similar findings were reported in early studies in the 1950s (73)(74)(75)(76)(77). In contrast, LSD (200µg, orally) did not alter diastolic or systolic blood pressure or heart rate in a recent study in eight patients with different chronic life-threatening illnesses (11).…”

The Occurrence of Depersonalization Phenomena under LSD

“…A nxiety and euphoria were in this scries of bo th norm als and p a tie n ts m ore com m only in duced th a n depression. The m ood changes were in fact sim ilar to those reported b y Stoll [1947], Iloch et al [1952], Forrer and Goldner [1951], DeShon et al [1952], Liddell and Weil-Malherbe [1953] and Savage [1952]. Sloane and Doust [1954] considered th a t th e m ood changes seem ed to be dependent upon th e affective sta te of the su b ject, prior to the ad m in istratio n of lysergic acid.…”

The potential role of lysergic acid diethylamide for psychological assisted therapy: A meta‐analysis of randomised controlled trials in healthy volunteers

“…LSD can cause significant autonomic effects, including blood pressure (systolic and diastolic), heart rate and body temperature. Early studies also reported similar conclusions in the 1950s (Belleville et al., 1956; Dimascio et al., 1957; Forrer & Goldner, 1951; Kornetsky, 1957; Sokoloff et al., 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life‐threatening after the administration of 200 mcg LSD orally.…”

“…Early studies also reported similar conclusions in the 1950s F I G U R E 6 Safety endpoints of autonomic effects for LSD of any drug dose compared with placebo. LSD: lysergic acid diethylamide, SD: standard deviation, CI: confidence interval, IV: inverse variance methods (Belleville et al, 1956;Dimascio et al, 1957;Forrer & Goldner, 1951;Kornetsky, 1957;Sokoloff et al, 1957). However, a recent study showed no significant changes in diastolic pressure, systolic pressure, or heart rate in eight patients with various chronic life-threatening after the administration of 200 mcg LSD orally.…”