Experimental Penetrating Keratoplasty in the Dog

Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

“…In DMEK, selective transplantation of DM and endothelium is performed while DSEK involves the selective transplantation of DM, endothelium, and posterior stromal lamellae. Of these three surgical techniques, only PK has been reported in canines with a rejection rate of 56% . To the authors’ knowledge, the use of DMEK or DSEK has not been reported in dogs.…”

“…To date, studies of corneal transplantation in dogs are sparse; thus, there are no well‐defined parameters for corneal graft rejection in dogs . Patient 6 had deep stromal vascularization and marked aqueous inflammation, which are common signs of rejection in humans.…”

Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

“…In DMEK, selective transplantation of DM and endothelium is performed while DSEK involves the selective transplantation of DM, endothelium, and posterior stromal lamellae. Of these three surgical techniques, only PK has been reported in canines with a rejection rate of 56% . To the authors’ knowledge, the use of DMEK or DSEK has not been reported in dogs.…”

“…To date, studies of corneal transplantation in dogs are sparse; thus, there are no well‐defined parameters for corneal graft rejection in dogs . Patient 6 had deep stromal vascularization and marked aqueous inflammation, which are common signs of rejection in humans.…”

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

“…These include penetrating keratoplasty (PK) and more recently Descemet's stripping endothelial keratoplasty (DSEK) and Descemet's membrane endothelial keratoplasty (DMEK) . While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases . Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye …”

“…[31][32][33] While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases. [34][35][36] Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye. 37,38 Assessment of the population of PCED dogs from a veterinary ophthalmic clinic provided disease signalment information beyond previous publications.…”

Biosynthetic Corneal Substitute Implantation in Dogs

“…23,24 Even under experimental conditions, most keratoplasties in dogs induce a moderate to severe inflammatory and vascular response and quickly become opaque, in contrast to the very mild haze formation found in this study. 25,26 The use of atelocollagen may have resulted in less reaction because it is the telopeptides in collagen that generally result in an inflammatory response. 27 …”

Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

“…In DMEK, selective transplantation of DM and endothelium is performed while DSEK involves the selective transplantation of DM, endothelium, and posterior stromal lamellae. Of these three surgical techniques, only PK has been reported in canines with a rejection rate of 56% . To the authors’ knowledge, the use of DMEK or DSEK has not been reported in dogs.…”

“…To date, studies of corneal transplantation in dogs are sparse; thus, there are no well‐defined parameters for corneal graft rejection in dogs . Patient 6 had deep stromal vascularization and marked aqueous inflammation, which are common signs of rejection in humans.…”

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

“…These include penetrating keratoplasty (PK) and more recently Descemet's stripping endothelial keratoplasty (DSEK) and Descemet's membrane endothelial keratoplasty (DMEK) . While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases . Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye …”

“…[31][32][33] While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases. [34][35][36] Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye. 37,38 Assessment of the population of PCED dogs from a veterinary ophthalmic clinic provided disease signalment information beyond previous publications.…”

Biosynthetic Corneal Substitute Implantation in Dogs

“…23,24 Even under experimental conditions, most keratoplasties in dogs induce a moderate to severe inflammatory and vascular response and quickly become opaque, in contrast to the very mild haze formation found in this study. 25,26 The use of atelocollagen may have resulted in less reaction because it is the telopeptides in collagen that generally result in an inflammatory response. 27 …”

Early postoperative results of Descemet’s stripping endothelial keratoplasty in six dogs with corneal endothelial dystrophy

“…In DMEK, selective transplantation of DM and endothelium is performed while DSEK involves the selective transplantation of DM, endothelium, and posterior stromal lamellae. Of these three surgical techniques, only PK has been reported in canines with a rejection rate of 56% . To the authors’ knowledge, the use of DMEK or DSEK has not been reported in dogs.…”

“…To date, studies of corneal transplantation in dogs are sparse; thus, there are no well‐defined parameters for corneal graft rejection in dogs . Patient 6 had deep stromal vascularization and marked aqueous inflammation, which are common signs of rejection in humans.…”

Superficial keratectomy as a treatment for non‐healing corneal ulceration associated with primary corneal endothelial degeneration

“…These include penetrating keratoplasty (PK) and more recently Descemet's stripping endothelial keratoplasty (DSEK) and Descemet's membrane endothelial keratoplasty (DMEK) . While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases . Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye …”

“…[31][32][33] While PK has been described in dogs, corneal, or endothelial keratoplasty transplantation techniques have not yet been developed for widespread use in canine PCED cases. [34][35][36] Keratoprosthesic surgeries with silicone implants have been described in dogs with corneal blindness: however, the technique has not been widely performed because of the complications associated with maintaining the implant and a comfortable functional eye. 37,38 Assessment of the population of PCED dogs from a veterinary ophthalmic clinic provided disease signalment information beyond previous publications.…”

Biosynthetic Corneal Substitute Implantation in Dogs

“…23,24 Even under experimental conditions, most keratoplasties in dogs induce a moderate to severe inflammatory and vascular response and quickly become opaque, in contrast to the very mild haze formation found in this study. 25,26 The use of atelocollagen may have resulted in less reaction because it is the telopeptides in collagen that generally result in an inflammatory response. 27 …”