Experimental pain sensitivity and reports of negative thoughts in adults with sickle cell disease

Gil, Karen M.; Phillips, George; Webster, Deborah A.; Martin, Nancy J.; Abrams, Mary Ann; Grant, Merida M.; Clark, W. Crawford

doi:10.1016/s0005-7894(05)80106-6

Cited by 26 publications

(22 citation statements)

References 34 publications

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“…Her score on the index will diminish as she becomes more willing to judge stimuli as painful across intensity levels, i.e., produce a large number of both hits and false alarms. Gil and colleagues provide a detailed description of the computations used to quantify performance on the indices of sensory discrimination and response bias (53).…”

Section: Cmz)mentioning

confidence: 99%

Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage

et al. 1998

Arthritis & Rheumatism

152

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Section: Cmz)mentioning

confidence: 99%

Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage

et al. 1998

Arthritis & Rheumatism

152

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“…For example, in non-SCD chronic pain conditions, lower pain tolerance [20;24] and higher levels of temporal summation [2] are associated with more frequent, intense, and disabling episodes of recent pain. The few studies that have examined QST in adults with sickle cell disease generally find enhanced sensitivity of thermal detection and reduced pain thresholds in patients with SCD [5;26;27]. A recent report found evidence of central sensitization in 60% of patients with SCD tested and a combination of central and peripheral sensitization in an additional 32% [23].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of Central Sensitization in Patients With Sickle Cell Disease

Campbell

Moscou-Jackson

Carroll

et al. 2016

The Journal of Pain

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Central sensitization (CS), nociceptive hyper-excitability known to amplify and maintain clinical pain, has been identified as a leading culprit responsible for maintaining pain in several chronic pain conditions. Recent evidence suggests that it may explain differences in the symptom experience of individuals with sickle cell disease (SCD). Quantitative sensory testing (QST) can be used to examine CS and identify individuals that may have a heightened CS profile. The present study categorized patients with SCD based on QST responses into a high or low CS phenotype and compared these groups on measures of clinical pain, vaso-occlusive crises, psychosocial factors, and sleep continuity. Eighty-three adult patients with SCD completed QST, questionnaires, daily sleep and pain diaries over a three-month period, weekly phone calls for three months, and monthly phone calls for 12 months. Patients were divided into CS groups (i.e. No/Low CS [n=17] vs. High CS [n=21]), based on thermal and mechanical temporal summation and aftersensations, which were norm-referenced to 47 healthy controls. High CS subjects reported more clinical pain, vaso-occlusive crises, catastrophizing, and negative mood, and poorer sleep continuity (p’s<0.05) over the 18-month follow-up period. Future analyses should investigate whether psychosocial disturbances and sleep mediate the relationship between central sensitization and pain outcomes. Perspective In general, sickle cell disease patients with greater central sensitization had higher clinical pain, more crises, worse sleep, and more psychosocial disturbances compared to the low CS group.

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“…Greater pain sensitivity, including lower pain tolerance [16;23] and higher levels of temporal summation [17], are associated with more frequent, intense, and disabling episodes of recent pain. The few studies that have examined QST in adults with sickle cell disease generally find that SCD patients are more sensitive to thermal detection and pain thresholds than healthy controls [7;27;28]. SCD patients also show evidence of central and/or peripheral sensitization and even a neuropathic pain component [22].…”

Section: Introductionmentioning

confidence: 99%

Quantitative sensory testing and pain-evoked cytokine reactivity

Campbell

Carroll

Kiley

et al. 2016

Pain

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Sickle cell disease (SCD) is an inherited blood disorder associated with significant morbidity, which includes severe episodic pain, and, often, chronic pain. Compared to healthy individuals, patients with SCD report enhanced sensitivity to thermal detection and pain thresholds and have altered inflammatory profiles, yet no studies to date have examined biomarker reactivity following laboratory-induced pain. We sought to examine this relationship in SCD patients compared to healthy control participants. We completed quantitative sensory testing (QST) in 83 patients with SCD and sequential blood sampling in 27 of them, whom we matched (sex, age, race, BMI, education) to 27 healthy controls. Surprisingly, few QST differences emerged between groups. Heat pain tolerance, pressure pain threshold at the trapezius, thumb and quadriceps, and thermal temporal summation at 45°C differed between groups in the expected direction, while conditioned pain modulation and pain ratings to hot water hand immersion were counterintuitive, possibly due to tailoring the water temperature to a perceptual level; SCD patients received milder temperatures. In the matched subsample, group differences and group by time interactions were observed in biomarkers including TNFα, IL-1β, IL-4, and NPY. These findings highlight the utility of laboratory pain testing methods for understanding individual differences in inflammatory cytokines. Our findings suggest amplified pain-evoked pro-inflammatory cytokine reactivity among patients with SCD relative to carefully matched controls. Future research is warranted to evaluate the impact of enhanced pain-related cytokine response and whether it is predictive of clinical characteristics and the frequency/severity of pain crises in SCD patients.

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Experimental pain sensitivity and reports of negative thoughts in adults with sickle cell disease

Cited by 26 publications

References 34 publications

Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage

Sexual and physical abuse in women with fibromyalgia: Association with outpatient health care utilization and pain medication usage

An Evaluation of Central Sensitization in Patients With Sickle Cell Disease

Quantitative sensory testing and pain-evoked cytokine reactivity

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