2013
DOI: 10.1371/journal.pone.0054807
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Abstract: BackgroundObstructive sleep apnea (OSA) is characterized by recurrent nocturnal hypoxia and sleep disruption. Sleep fragmentation caused hyperalgesia in volunteers, while nocturnal hypoxemia enhanced morphine analgesic potency in children with OSA. This evidence directly relates to surgical OSA patients who are at risk for airway compromise due to postoperative use of opioids. Using accepted experimental pain models, we characterized pain processing and opioid analgesia in male volunteers recruited based on th… Show more

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Cited by 91 publications
(67 citation statements)
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References 87 publications
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“…27,28 Furthermore, insulin growth factor binding protein-1 (IGFBP-1), a serum marker of hypoxia, 29 is associated with hypoalgesia to experimental heat, as well as increased potency of opioid analgesia. 30 Consistent with these findings, Doufas and colleagues 30 have shown that nocturnal hypoxemia in subjects at high risk for OSA was associated with an increased potency of opioid analgesia.…”
Section: Discussionmentioning
confidence: 84%
“…27,28 Furthermore, insulin growth factor binding protein-1 (IGFBP-1), a serum marker of hypoxia, 29 is associated with hypoalgesia to experimental heat, as well as increased potency of opioid analgesia. 30 Consistent with these findings, Doufas and colleagues 30 have shown that nocturnal hypoxemia in subjects at high risk for OSA was associated with an increased potency of opioid analgesia.…”
Section: Discussionmentioning
confidence: 84%
“…Negative mood might play a role in this bi-directional interaction between pain and sleep quality [197e199]. We should also remark that recent experimental evidence suggests that SDB may reduce the pain threshold thereby potentially increasing the frequency and severity of pain episodes in patients with SCD [200,201].…”
Section: Erectile Dysfunctionmentioning
confidence: 99%
“…Hospitalized patients often have comorbidities or physiological disturbances which might increase their risk related to use of these medications. Opioids can cause central and obstructive sleep apneas (1921), and benzodiazepines contribute to respiratory depression and airway relaxation (22). Benzodiazepines also impair psychomotor function and recall (23), which could mediate the recognized risk for delirium and falls in the hospital (24, 25).…”
Section: Introductionmentioning
confidence: 99%