Experimental oral toxicity of domoic acid in cynomolgus monkeys (Macaca fascicularis) and rats.

Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.

“…An approximately fourfold greater sensitivity to domoate-induced neurotoxicity was observed in adult animals as compared to juveniles. These results are in agreement with previous work indicating that mussel extract and purified domoate damaged the CAI, CA3, and CA4 subfields of the hippocampus (17,26,27).…”

Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.

“…An approximately fourfold greater sensitivity to domoate-induced neurotoxicity was observed in adult animals as compared to juveniles. These results are in agreement with previous work indicating that mussel extract and purified domoate damaged the CAI, CA3, and CA4 subfields of the hippocampus (17,26,27).…”

Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

“…In humans and non-human primates, ~2 mg/kg of domoic acid taken orally can induce gastrointestinal disorder symptoms, while a slightly higher concentration can cause different neurological effects. Similar neurotoxic effects have been described for other species ranging from zebrafish to sea lions, as previously reported [ 32 , 93 , 94 , 95 , 96 ].…”

Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases

“…DomA is a potent neurotoxin, that was identified as the toxic agent responsible for an outbreak of poisoning due to consumption of contaminated shellfish (Perl et al 1990). Neuronal loss, particularly in the hippocampus and the amygdala, was observed in the four individuals who died in this incident (Teitelbaum et al 1990), and similar brain lesions have been seen in primates, rats and mice following administration of DomA (Tryphonas et al 1990;Strain and Tasker, 1991;Scallet et al 1993;Sobotka et al 1996). The pattern of brain damage observed in humans and animals following exposure to DomA resembles that observed after administration of kainic acid (Teitelbaum, 1990).…”

Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.

“…An approximately fourfold greater sensitivity to domoate-induced neurotoxicity was observed in adult animals as compared to juveniles. These results are in agreement with previous work indicating that mussel extract and purified domoate damaged the CAI, CA3, and CA4 subfields of the hippocampus (17,26,27).…”

Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

“…In humans and non-human primates, ~2 mg/kg of domoic acid taken orally can induce gastrointestinal disorder symptoms, while a slightly higher concentration can cause different neurological effects. Similar neurotoxic effects have been described for other species ranging from zebrafish to sea lions, as previously reported [ 32 , 93 , 94 , 95 , 96 ].…”

Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases

“…DomA is a potent neurotoxin, that was identified as the toxic agent responsible for an outbreak of poisoning due to consumption of contaminated shellfish (Perl et al 1990). Neuronal loss, particularly in the hippocampus and the amygdala, was observed in the four individuals who died in this incident (Teitelbaum et al 1990), and similar brain lesions have been seen in primates, rats and mice following administration of DomA (Tryphonas et al 1990;Strain and Tasker, 1991;Scallet et al 1993;Sobotka et al 1996). The pattern of brain damage observed in humans and animals following exposure to DomA resembles that observed after administration of kainic acid (Teitelbaum, 1990).…”

Establishing tolerable dungeness crab (Cancer magister) and razor clam (Siliqua patula) domoic acid contaminant levels.

“…An approximately fourfold greater sensitivity to domoate-induced neurotoxicity was observed in adult animals as compared to juveniles. These results are in agreement with previous work indicating that mussel extract and purified domoate damaged the CAI, CA3, and CA4 subfields of the hippocampus (17,26,27).…”

Domoic Acid: A Review of Its Cytogenotoxicity Within the One Health Approach

“…In humans and non-human primates, ~2 mg/kg of domoic acid taken orally can induce gastrointestinal disorder symptoms, while a slightly higher concentration can cause different neurological effects. Similar neurotoxic effects have been described for other species ranging from zebrafish to sea lions, as previously reported [ 32 , 93 , 94 , 95 , 96 ].…”

Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases

“…DomA is a potent neurotoxin, that was identified as the toxic agent responsible for an outbreak of poisoning due to consumption of contaminated shellfish (Perl et al 1990). Neuronal loss, particularly in the hippocampus and the amygdala, was observed in the four individuals who died in this incident (Teitelbaum et al 1990), and similar brain lesions have been seen in primates, rats and mice following administration of DomA (Tryphonas et al 1990;Strain and Tasker, 1991;Scallet et al 1993;Sobotka et al 1996). The pattern of brain damage observed in humans and animals following exposure to DomA resembles that observed after administration of kainic acid (Teitelbaum, 1990).…”