Experimental models of febrile seizures and febrile status epilepticus

Warming Up to the Notion That Febrile Seizures Can Be Associated With Cognitive Impairment

“…6 While several aspects of human FS can be mimicked in animal models, some questions remain unanswered. 7 Most studies of experimental FS, including the present one 8 utilize hyperthermia as a surrogate for actual fever, which can be difficult to induce in a rodent. Yet, even in humans, it is not clear whether fever itself or the illness-induced signaling changes or inflammation “cause” the FS.…”