Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense

Souza, Celso Eduardo de; Moraes‐Filho, Jonas; Ogrzewalska, Maria; Uchoa, Franscisco C.; Horta, Maurício Cláudio; Souza, Savina S.L.; Borba, Renata C.M.; Labruna, Marcelo Bahia

doi:10.1016/j.vetpar.2008.12.010

Cited by 117 publications

(127 citation statements)

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“…As capivaras (Hydrochoerus hydrochaeris), hospedeiros primários de todos os estádios parasitários do Amblyomma cajennense e Amblyomma dubitatum, são consideradas um potencial reservatório de Rickettsia sp (5,19,(29)(30)(31).…”

Section: Resultsunclassified

Inquérito Epidemiológico De Suposto Foco De Febre Maculosa

et al. 2016

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Resumo O presente estudo objetivou avaliar a suspeita de ocorrência da febre maculosa (FM) em Quirinópolis - GO, por meio de inquérito sorológico em amostras de humanos, cães e equinos e identificação de carrapatos vetores. Em 2007, foram realizadas reações de imunofluorescência indireta (RIFI) para Rickettsia spp. em amostras de sangue colhidas de 28 pessoas do grupo de convívio de um caso suspeito (uma criança de três anos que apresentou sinais de riquetsiose, após exposição a carrapatos). Também foram colhidas amostras de sangue em cinco cães e 42 equinos, havendo soro reagentes somente entre os equinos (28,6%). Não foi constatada a presença do carrapato Amblyomma cajennense. Sete indivíduos foram reagentes para Rickettsia spp., a maioria desses eram parentes paternos do caso suspeito. Em 2008, na mesma região, foram realizadas RIFI em amostras de 30 humanos sem sinais clínicos de FM e constatou-se 50% de soro reagentes para Rickettsia spp. Adicionalmente, colheram-se amostras de sangue de 24 cães errantes, havendo um cão soropositivo. A evidência sorológica do contato entre bactérias do gênero Rickettsia com habitantes humanos e animais de Quirinópolis indica que a FM ou outra riquetsiose possa estar ocorrendo no Estado de Goiás.

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Section: Resultsunclassified

Inquérito Epidemiológico De Suposto Foco De Febre Maculosa

et al. 2016

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“…According to Souza et al 18,19 , in the region of Campinas, most cases of BSF are related to the population growth of the capybara, one of the main primary hosts for all of the developmental stages of the A. cajennense tick 19 .…”

Section: Discussionmentioning

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Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution

Nasser

Lana²,

Silva³

et al. 2015

Rev. bras. epidemiol.

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Introduction: Brazilian spotted fever is an emerging zoonosis notified mainly in the Southeast of Brazil, especially due to its high level of lethality. Objective: To analyze the epidemiological and spatial pattern of the disease in the municipality of Valinhos (106,793 inhabitants), São Paulo, Southeastern region of Brazil, in the period between 2001 and 2012. Methods: All laboratory-confirmed cases with likely site of infection in the city (n = 49) notified in the Brazilian Case Registry Database were studied. Sites were geocoded using the cartographic base of the city and Google Earth (geographic coordinates) with correction according to the Brazilian Geodetic System. We used the Kernel estimator to analyze the density of the cases on the map. Land cover and distance to basins of all cases were analyzed. Information about tick species and primary hosts were obtained from reports of the Superintendence of Control of Endemic Diseases. Results: Seasonality of the disease was observed with the highest incidence from June to November, and in 2005 and 2011. The most affected groups were men (79.6%) aged 20-49 years old (49%). Lethality was found to be 42.9%. Maps showed the progressive registration of cases in the urban area. Capybaras were reported as the main primary host, and Amblyomma cajennense was identified in probable sites of infection during field investigation. The likely sites of infection were mostly located near basins, dirty pastures, and bordering woods. Conclusions: The transmission pattern of Brazilian spotted fever in Valinhos is similar to that in other cities in the region, where capybara is the main primary host and an amplifier of R. rickettsii. Over the years, a higher occurrence of cases has been identified in the urban area of the city.

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“…En Brasil, donde los principales huéspedes de A. cajennense son los caballos y los capibaras, el aumento de la población de estos últimos se ha relacionado con el incremento de casos de fiebre manchada de Brasil en áreas endémicas para esta rickettsiosis (12).…”

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“…En el caso de A. cajennense, puede atribuirse principalmente a que esta garrapata es menos propensa a la infección por R. rickettsii que otras especies (11). El papel de huéspedes amplificadores vertebrados que desarrollen grandes rickettsiemias es indispensable para el mantenimiento de la rickettsia en su ciclo enzoótico, al infectar nuevas garrapatas y comenzar nuevos linajes de garrapatas infectadas (12 (10). Los humanos también pueden ser atacados por todos los estadios de la garrapata, usualmente por cientos de larvas, docenas de ninfas y pocos adultos (4).…”

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Vigilancia de la infección por Rickettsia sp. en capibaras (Hydrochoerus hydrochaeris) un modelo potencial de alerta epidemiológica en zonas endémicas

et al. 2011

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, 2008). El presente estudio reporta por primera vez la presencia de infección natural por rickettsia del grupo de las fiebres manchadas en capibaras de Colombia. Los hallazgos sugieren que los capibaras pueden ser usados como potenciales centinelas de la circulación de rickettsias y marcadores de las áreas de riesgo para la transmisión de rickettsiosis.Palabras clave: Rickettsia sp., infecciones por rickettsiaceae, roedores, garrapatas, técnica indirecta del anticuerpo fluorescente, Colombia. Surveillance of Rickettsia sp. infection in capybaras (Hydrochoerus hydrochaeris) a potential model of epidemiological alert in endemic areasIntroduction. Capybaras (Hydrochoerus hydrochaeris) are considered amplifying hosts of Rickettsia sp. These rodents are usually parasitized by the tick vector, Amblyomma cajennense, the main vector of rickettsioses in humans and animals in South America. Capybaras can be used as sentinels in detection of circulation of rickettsiae.Objective. Antibodies to rickettsiae of spotted fever group were detected in capybaras in a rural area of Cordoba Province, northern Colombia. Materials and methods. Sera were analyzed from 36 capybaras in a rural area of Monteria (village of San Jeronimo) in Córdoba. For the detection of IgG antibodies, indirect immunofluorescence was performed. The antigens were derived from R. rickettsia strain Taiaçu isolated in Brazil. Capybara sera were diluted 1:64 for IFA analysis. Ticks were collected from each capybara (also known as chigüiro) and identified to species.Results. The seroprevalence of spotted fever group Rickettsia was 22% (8 capybaras). Four sera had a titer of 1:64, 3 had a titer of 1:128 and one serum had a titer of 1:512. All ticks removed from the capybaras (n=933) were taxonomically identified as Amblyomma cajennense. Conclusion. Colombia has areas endemic for rickettsioses, as indicated by confirmed annual outbreaks. The current study reports the first evidence of natural rickettsial infection of the spotted fever group in capybaras from Colombia. The findings suggest that capybaras can be used as sentinels for the circulation of rickettsiae and can identify endemic areas for the transmission of rickettsial diseases.

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Experimental infection of capybaras Hydrochoerus hydrochaeris by Rickettsia rickettsii and evaluation of the transmission of the infection to ticks Amblyomma cajennense

Cited by 117 publications

References 14 publications

Inquérito Epidemiológico De Suposto Foco De Febre Maculosa

Inquérito Epidemiológico De Suposto Foco De Febre Maculosa

Urbanization of Brazilian spotted fever in a municipality of the southeastern region: epidemiology and spatial distribution

Vigilancia de la infección por Rickettsia sp. en capibaras (Hydrochoerus hydrochaeris) un modelo potencial de alerta epidemiológica en zonas endémicas

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