Experimental Induction of Liver Tumours in Rainbow Trout (<i>Salmo gairdneri</i>) by Contaminated Sediment from Hamilton Harbour, Ontario

Metcalfe, C. D.; Cairns, Victor W.; Fitzsimons, John D.

doi:10.1139/f88-251

Cited by 62 publications

(29 citation statements)

References 2 publications

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“…Although experimental evidence has shown that liver neoplasms can be induced by exposure of fish to contaminated sediments (Metcalf et al 1988;, the development of these lesions is thought to occur slowly. Furthermore, it has been suggested that regression and re-modelling of lesions such as hepatocellular FCA, back into normal parenchyma is possible if the stimulating contaminant is removed (Myers et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Histopathological alterations in Senegal sole, Solea Senegalensis, from a polluted Huelva estuary (SW, Spain)

Oliva

Martorell

Riaño

et al. 2012

Fish Physiol Biochem

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As a component of a large research project to evaluate the effects of contaminants on fish health in the field, histopathological studies have been conducted to help establish causal relationship between pollutants (heavy metals and aromatic polycyclic hydrocarbonsPAHs) and histopathological responses in Senegal sole, Solea senegalensis, from an estuary of SW Spain. Heavy metals (As, Zn, Cd, Pb, Cu and Fe) and 16 PAHs (proprietary USEPA) concentrations in water, sediment and tissues (liver and gills) and histopathological alterations in S. senegalensis from three sampling sites of Ria de Huelva estuary during 2004-2006 years have been analysed. The histopathological studies revealed seasonal and spatial differences in the lesion grade of alterations observing the highest lesion grades in fish from Odiel River and autumn season. No significant differences were observed in the alterations prevalence between sampling sites, but significant differences were observed between seasons observing the highest prevalence in autumn season. However, calculated IPAT demonstrated a lowmoderate impact of pollutants on health fish. Correlations between histopathological alterations and pollutants analysed were observed being heavy metals the group that presented a major number of correlations with alterations in several organs of S. senegalensis. In evaluating the general health of fish, the use of histopathological studies in recommended for making more reliable assessment of biochemical responses in fish exposed to a variety of environmental stressors. Statistical analysis using semiquantitative data on pathological lesions can help to establish correlation between cause (stressor) and effect (biomarker).

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Section: Discussionmentioning

confidence: 99%

Histopathological alterations in Senegal sole, Solea Senegalensis, from a polluted Huelva estuary (SW, Spain)

Oliva

Martorell

Riaño

et al. 2012

Fish Physiol Biochem

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“…There is a consensus, however, that vacuolated hepatocytes are frequently found proximal to neoplasms and that tumor prevalence is associated with increasing numbers of vacuolated liver cells and that, the extent of deformity and cell injury is also consistent with hepatotoxicant action [4,11]. PAH's have been implicated in the development of liver carcinogenesis [5,14,30] and a cause and effect relationship between PAH's and liver tumors or preneoplastic lesions in fish has been established by in-vitro studies [16,28]. Our observations in the present study could be attributable in part to this chemical group, as measurable levels of heavy metals, hydrocarbons, organo-chlorines, PAH's and PCB's have been reported in the Lagos lagoon complex by Ajao et al [1].…”

Section: Discussionmentioning

confidence: 99%

Hepatic Pathologies in the Brackish Water Catfish ( Chrysichthys Nigrodigitatus ) From Contaminated Locations of the Lagos Lagoon Complex

Olarinmoye¹

2009

Appl Ecol Env Res

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Abstract. Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in literature. The focus on the liver in these studies is predicated on its central nature in the scheme of biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a consequence of the latter primary role of the liver in these processes it is regarded as a predilective site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level. Hepatic histopathology recorded in livers from feral populations of the brackish water catfish Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6 0 24'N, 2 0 56'E; and Lagos lagoon: 6 0 29'N, 3 0 22'E) were analysed. Observed pathologies included hydropic degeneration (58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of cellular alterations (FCA's). No obvious oncologic features were observed; the presence of the hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as such.

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“…The discussion below interprets the toxicological significance, to the extent possible, of the complex associations between lesion types and measures of potential contaminant exposure, actual dietary uptake, hepatic Volume 102, Number 2, February 1994 aAnalyses were performed separately while adjusting for mean age and gender ratio (female:male). (2,10-12, 75,76) and which significantly co-occur with neoplasms in English sole (18) (3,15,24,25,39,59), in studies in other species of wild fish (69,77,78) and the hepatocarcinogenicity of genotoxic PAHs in laboratory studies with fish (5,41,42,(79)(80)(81). XPAHs in sediment from English sole sites ranged from undetectable at the Nisqually River reference site to 5900 ng/g in Elliott Bay, comparable to levels in previous studies where the relationship between PAH exposure and neoplasms was first established in this species (15).…”

Section: Relationships Between Chemical Contaminants and Hepatic Lesionsmentioning

confidence: 99%

Relationships between toxicopathic hepatic lesions and exposure to chemical contaminants in English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus) from selected marine sites on the Pacific Coast, USA.

Myers

Stehr

Olson

et al. 1994

Environ Health Perspect

145

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Relationships between hepatic lesions and chemical contaminant concentrations in sediments, stomach contents, liver tissue, and bile were statistically evaluated in three species of bottomfish, English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus), captured from 27 urban and nonurban sites on the Pacific Coast from Alaska to southern California. Lesions detected were neoplasms, preneoplastic foci of cellular alteration, nonneoplastic proliferative lesions, unique or specific degenerative/necrotic lesions, nonspecific degenerative/necrotic lesions, and hydropic vacuolation of biliary epithelial cells and hepatocytes. In general, lesion prevalences were significantly higher in all three species captured at chemically contaminated urban sites, and certain lesions had significantly higher relative risks of occurrence at urban sites in Puget Sound, San Francisco Bay, the vicinity of Los Angeles, and San Diego Bay. Concentrations of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, DDT and its derivatives, and chlordanes and dieldrin in sediment, stomach contents, liver, and fluorescent aromatic compounds in bile were significant risk factors for the occurrence of neoplastic, preneoplastic, nonneoplastic proliferative, and specific degenerative/necrotic lesions, as well as hydropic vacuolation. Fish age also had a significant influence on occurrence of several hepatic lesions, but gender was rarely a significant risk factor. These relationships provide strong evidence for the involvement of environmental contaminants in the etiology of hepatic lesions in several marine bottomfish species and clearly indicate the utility of these lesions as biomarkers of contaminant-induced effects in wild fish. Images Figure 2. A Figure 2. B Figure 3. Figure 4. A Figure 4. B

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Experimental Induction of Liver Tumours in Rainbow Trout (Salmo gairdneri) by Contaminated Sediment from Hamilton Harbour, Ontario

Cited by 62 publications

References 2 publications

Histopathological alterations in Senegal sole, Solea Senegalensis, from a polluted Huelva estuary (SW, Spain)

Histopathological alterations in Senegal sole, Solea Senegalensis, from a polluted Huelva estuary (SW, Spain)

Hepatic Pathologies in the Brackish Water Catfish ( Chrysichthys Nigrodigitatus ) From Contaminated Locations of the Lagos Lagoon Complex

Relationships between toxicopathic hepatic lesions and exposure to chemical contaminants in English sole (Pleuronectes vetulus), starry flounder (Platichthys stellatus), and white croaker (Genyonemus lineatus) from selected marine sites on the Pacific Coast, USA.

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