Experimental Inclusion Conjunctivitis in Man

Otitis media in adults with chlamydial conjunctivitis

“…3 Our study showed a similar prevalence of otological symptoms in patients with naturally acquired chlamydial conjunctivitis (13%). Occasional reports of OM with isolation of C trachomatis from the middle ear aspirate in adults with chlamydial conjunctivitis have been published.…”

“…5 OM may result from direct infection from the conjunctiva via the eustachian tube (which probably occurred in cases 1 and 2), or secondary to its blockage following nasopharyngeal lymphoid hypertrophy (which is the probable explanation in cases 3 and 4). 3 C trachomatis has been detected in middle ear aspirates by culture or PCR in children and adults with OM in the absence of chlamydial conjunctivitis 6 7 although these findings have not been reproduced by others investigating OM in children. 8 9 However, C pneumoniae is the more likely species to be involved in children with acute OM.…”

Otitis media in adults with chlamydial conjunctivitis

“…3 Our study showed a similar prevalence of otological symptoms in patients with naturally acquired chlamydial conjunctivitis (13%). Occasional reports of OM with isolation of C trachomatis from the middle ear aspirate in adults with chlamydial conjunctivitis have been published.…”

“…5 OM may result from direct infection from the conjunctiva via the eustachian tube (which probably occurred in cases 1 and 2), or secondary to its blockage following nasopharyngeal lymphoid hypertrophy (which is the probable explanation in cases 3 and 4). 3 C trachomatis has been detected in middle ear aspirates by culture or PCR in children and adults with OM in the absence of chlamydial conjunctivitis 6 7 although these findings have not been reproduced by others investigating OM in children. 8 9 However, C pneumoniae is the more likely species to be involved in children with acute OM.…”

Neonatal chlamydial conjunctivitis.

“…16 17 Systemic immunity seemed to be more important than local immunity in those experiments. Antibodies to a genus antigen determined by complement fixation present before the challenge did not prevent infection.…”

Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited against a Vaginal Challenge with Chlamydia muridarum

“…The negative control groups OVA/Z3-14 (25; 14–35), OVA/A8-35 (28; 14–35), or MEM-0 (32; 21–35), shed longer than the nMOMP vaccinated animals, while the positive control Cm -EB immunized group had the shortest shedding time (4; 4–14). …”

Otitis media in adults with chlamydial conjunctivitis

“…3 Our study showed a similar prevalence of otological symptoms in patients with naturally acquired chlamydial conjunctivitis (13%). Occasional reports of OM with isolation of C trachomatis from the middle ear aspirate in adults with chlamydial conjunctivitis have been published.…”

“…5 OM may result from direct infection from the conjunctiva via the eustachian tube (which probably occurred in cases 1 and 2), or secondary to its blockage following nasopharyngeal lymphoid hypertrophy (which is the probable explanation in cases 3 and 4). 3 C trachomatis has been detected in middle ear aspirates by culture or PCR in children and adults with OM in the absence of chlamydial conjunctivitis 6 7 although these findings have not been reproduced by others investigating OM in children. 8 9 However, C pneumoniae is the more likely species to be involved in children with acute OM.…”

Neonatal chlamydial conjunctivitis.

“…16 17 Systemic immunity seemed to be more important than local immunity in those experiments. Antibodies to a genus antigen determined by complement fixation present before the challenge did not prevent infection.…”

Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited against a Vaginal Challenge with Chlamydia muridarum

“…The negative control groups OVA/Z3-14 (25; 14–35), OVA/A8-35 (28; 14–35), or MEM-0 (32; 21–35), shed longer than the nMOMP vaccinated animals, while the positive control Cm -EB immunized group had the shortest shedding time (4; 4–14). …”

Otitis media in adults with chlamydial conjunctivitis

“…3 Our study showed a similar prevalence of otological symptoms in patients with naturally acquired chlamydial conjunctivitis (13%). Occasional reports of OM with isolation of C trachomatis from the middle ear aspirate in adults with chlamydial conjunctivitis have been published.…”

“…5 OM may result from direct infection from the conjunctiva via the eustachian tube (which probably occurred in cases 1 and 2), or secondary to its blockage following nasopharyngeal lymphoid hypertrophy (which is the probable explanation in cases 3 and 4). 3 C trachomatis has been detected in middle ear aspirates by culture or PCR in children and adults with OM in the absence of chlamydial conjunctivitis 6 7 although these findings have not been reproduced by others investigating OM in children. 8 9 However, C pneumoniae is the more likely species to be involved in children with acute OM.…”

Neonatal chlamydial conjunctivitis.

“…16 17 Systemic immunity seemed to be more important than local immunity in those experiments. Antibodies to a genus antigen determined by complement fixation present before the challenge did not prevent infection.…”

Increased Immunoaccessibility of MOMP Epitopes in a Vaccine Formulated with Amphipols May Account for the Very Robust Protection Elicited against a Vaginal Challenge with Chlamydia muridarum

“…The negative control groups OVA/Z3-14 (25; 14–35), OVA/A8-35 (28; 14–35), or MEM-0 (32; 21–35), shed longer than the nMOMP vaccinated animals, while the positive control Cm -EB immunized group had the shortest shedding time (4; 4–14). …”