Experimental Herpes Simplex Keratitis

Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells

“…In humans as well as in experimental animals, HSV-1 infection of corneal epithelium elicits very little infiltration of inflammatory cells, whereas HSV-1 infection of keratocytes within the stromal layer is characterized by an intense infiltration of neutrophils and lymphocytes (40,41,65). It is tempting to speculate therefore that the differences in the capacities of the two cell types to produce IL-8 following HSV-1 infection contribute to the differences in the numbers of inflammatory cells seen in the two layers of infected corneas.…”

Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells

“…In humans as well as in experimental animals, HSV-1 infection of corneal epithelium elicits very little infiltration of inflammatory cells, whereas HSV-1 infection of keratocytes within the stromal layer is characterized by an intense infiltration of neutrophils and lymphocytes (40,41,65). It is tempting to speculate therefore that the differences in the capacities of the two cell types to produce IL-8 following HSV-1 infection contribute to the differences in the numbers of inflammatory cells seen in the two layers of infected corneas.…”

Herpes simplex keratitis: challenges in diagnosis and clinical management

“……”

Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells

“…In humans as well as in experimental animals, HSV-1 infection of corneal epithelium elicits very little infiltration of inflammatory cells, whereas HSV-1 infection of keratocytes within the stromal layer is characterized by an intense infiltration of neutrophils and lymphocytes (40,41,65). It is tempting to speculate therefore that the differences in the capacities of the two cell types to produce IL-8 following HSV-1 infection contribute to the differences in the numbers of inflammatory cells seen in the two layers of infected corneas.…”

Herpes simplex keratitis: challenges in diagnosis and clinical management

“……”

Induction of interleukin-8 gene expression is associated with herpes simplex virus infection of human corneal keratocytes but not human corneal epithelial cells

“…In humans as well as in experimental animals, HSV-1 infection of corneal epithelium elicits very little infiltration of inflammatory cells, whereas HSV-1 infection of keratocytes within the stromal layer is characterized by an intense infiltration of neutrophils and lymphocytes (40,41,65). It is tempting to speculate therefore that the differences in the capacities of the two cell types to produce IL-8 following HSV-1 infection contribute to the differences in the numbers of inflammatory cells seen in the two layers of infected corneas.…”

Herpes simplex keratitis: challenges in diagnosis and clinical management

“……”