Experimental Glaucoma Damage Mechanism

Rodent Models for Glaucoma Retinopathy and Optic Neuropathy

“…16 Without the necessary neurotrophic factors, RGC slowly die of apoptosis. [17][18][19] Vascular Insufficiency…”

Rodent Models for Glaucoma Retinopathy and Optic Neuropathy

“…16 Without the necessary neurotrophic factors, RGC slowly die of apoptosis. [17][18][19] Vascular Insufficiency…”

Preservation of Retina Ganglion Cell Function by Morphine in a Chronic Ocular-Hypertensive Rat Model

“…It is believed that elevated IOP causes distortion or ''bowing'' of the extracellular matrix (ECM) plates, which in turn damages axon bundles by mechanical stress and eventually leads to retinal ganglion cell (RGC) death. 2,3 Although a major risk factor for the development of glaucoma is elevated IOP, the pathophysiological mechanisms by which elevated IOP leads to optic nerve atrophy and retina degeneration are unknown.…”

Contribution of microglia‐mediated neuroinflammation to retinal degenerative diseases

“…Abnormal microglia reactivity and distribution have been observed in animal models of RGC degeneration, as the optic nerve axotomy model [105][106][107] and retinal ischemia [77,108], suggesting that microglia become reactive secondary to RGC degeneration. Nevertheless, direct evidence of the contribution of microglia to the loss of RGCs in glaucoma was provided by the observations that microglial cells proliferate in the vicinity of RGCs [109] and that the recruitment and activation of microglial cells occurs before RGC death [99].…”

Rodent Models for Glaucoma Retinopathy and Optic Neuropathy

“…16 Without the necessary neurotrophic factors, RGC slowly die of apoptosis. [17][18][19] Vascular Insufficiency…”

Preservation of Retina Ganglion Cell Function by Morphine in a Chronic Ocular-Hypertensive Rat Model

“…It is believed that elevated IOP causes distortion or ''bowing'' of the extracellular matrix (ECM) plates, which in turn damages axon bundles by mechanical stress and eventually leads to retinal ganglion cell (RGC) death. 2,3 Although a major risk factor for the development of glaucoma is elevated IOP, the pathophysiological mechanisms by which elevated IOP leads to optic nerve atrophy and retina degeneration are unknown.…”

Contribution of microglia‐mediated neuroinflammation to retinal degenerative diseases

“…Abnormal microglia reactivity and distribution have been observed in animal models of RGC degeneration, as the optic nerve axotomy model [105][106][107] and retinal ischemia [77,108], suggesting that microglia become reactive secondary to RGC degeneration. Nevertheless, direct evidence of the contribution of microglia to the loss of RGCs in glaucoma was provided by the observations that microglial cells proliferate in the vicinity of RGCs [109] and that the recruitment and activation of microglial cells occurs before RGC death [99].…”

Rodent Models for Glaucoma Retinopathy and Optic Neuropathy

“…16 Without the necessary neurotrophic factors, RGC slowly die of apoptosis. [17][18][19] Vascular Insufficiency…”

Preservation of Retina Ganglion Cell Function by Morphine in a Chronic Ocular-Hypertensive Rat Model

“…It is believed that elevated IOP causes distortion or ''bowing'' of the extracellular matrix (ECM) plates, which in turn damages axon bundles by mechanical stress and eventually leads to retinal ganglion cell (RGC) death. 2,3 Although a major risk factor for the development of glaucoma is elevated IOP, the pathophysiological mechanisms by which elevated IOP leads to optic nerve atrophy and retina degeneration are unknown.…”

Contribution of microglia‐mediated neuroinflammation to retinal degenerative diseases

“…Abnormal microglia reactivity and distribution have been observed in animal models of RGC degeneration, as the optic nerve axotomy model [105][106][107] and retinal ischemia [77,108], suggesting that microglia become reactive secondary to RGC degeneration. Nevertheless, direct evidence of the contribution of microglia to the loss of RGCs in glaucoma was provided by the observations that microglial cells proliferate in the vicinity of RGCs [109] and that the recruitment and activation of microglial cells occurs before RGC death [99].…”