Experimental examination of a targeted hyperthermia system using inductively heated ferromagnetic microspheres in rabbit kidney

Jones, Stephen; Winter, J G

doi:10.1088/0031-9155/46/2/308

Cited by 25 publications

(8 citation statements)

References 18 publications

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“…Jordan et al [113] have shown that SAR can be optimized through magnetic fractionation of the starting colloid, i.e., by selecting a small particle size window from the original size distribution. In addition to particle size and shape influence on heating power [114][115][116], the magnetic field amplitude and frequency must be considered when comparing experiments in Table IV.…”

Section: Hyperthermiamentioning

confidence: 99%

Magnetic Nanoparticles for Cancer Therapy

Goya¹,

Grazú²,

Ibarra

2008

CNANO

255

161

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Today, technologies based on magnetic nanoparticles (MNPs) are routinely applied to biological systems with diagnostic or therapeutic purposes. The paradigmatic example is the magnetic resonance imaging (MRI), a technique that uses the magnetic moments of MNPs as a disturbance of the proton resonance to obtain images. Similarly, magnetic fluid hyperthermia (MFH) uses MNPs as heat generators to induce localized cell death. The physical basis of these techniques relies on the interaction with external magnetic fields, and therefore the magnetic moment of the particles has to be maximized for these applications. Targeted drug-delivery based on 'smart' nanoparticles is the next step towards more efficient oncologic therapies, by delivering a minimal dose of drug only to the vicinity of the target. Current improvements in this fields relay on a) particle functionalization with specific ligands for targeting cell membrane receptors and b) loading MNPs onto cells (e.g., dendritic cells, T-cells, macrophages) having an active role in tumor grow. Here we review the current state of research on applications of magnetic carriers for cancer therapy, discussing the advances and drawbacks of both passive and targeted delivery of MNPs. The most promising strategies for targeted delivery of MNPs are analyzed, evaluating the expected impact on clinical MRI and MFH protocols.

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Section: Hyperthermiamentioning

confidence: 99%

Magnetic Nanoparticles for Cancer Therapy

Goya¹,

Grazú²,

Ibarra

2008

CNANO

255

161

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“…[47] Wu et al and Jones and Winter used MNPs in the treatment of hepatocellular carcinoma embolization. [47,48] In the follow up of these initial experiments, some research teams used animals to show the effectiveness of this method. [48] • Lubbe and co-workers conducted the Stage-I clinical study using magnetically focused medication transport.…”

Section: The Evolution Of Magnetic Drug Deliverymentioning

confidence: 99%

“…[47,48] In the follow up of these initial experiments, some research teams used animals to show the effectiveness of this method. [48] • Lubbe and co-workers conducted the Stage-I clinical study using magnetically focused medication transport. [49] Electrostatic connections involving phosphate units were attached to the granular exterior and amino groups contained inside the medication.…”

Section: The Evolution Of Magnetic Drug Deliverymentioning

confidence: 99%

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

Aslam

Shukrullah

Naz

et al. 2021

Part & Part Syst Charact

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encountering non-target tissues, cells, or areas. [2] An overview of the general drug delivery system is given in Figure 1. Over four decades ago, the idea of "magnetized medication delivery" was proposed as a highly potential use of magnetic nanoparticles. Magnetic nanostructures are granules comprising of polymeric materials and medicine together with ferromagnetic components (magnetite). Substances utilized in the creation of nanostructures are sterilizable, harmless, and disposable; good examples include gelatin, ethyl cellulose, albumin, and collagen. [3] The idea of magnetostrictive aiming begins with linking active ingredients to magnetic nanocrystals accompanied by the infusion and assistance of these molecules to a target tissue under the impact of regionalized strong magnetic field and keeping there at site till the completion of the treatment and ultimate disposal. Literature shows six kinds of magnetic substances, i.e., antiferromagnetic, ferromagnetic, superparamagnetic, ferromagnetic, paramagnetic and diamagnetic. [4] The detail of these substances is given in Table 1. Once the external field is withdrawn, paramagnetic components shed magnetic momentum and super-paramagnetic substances turn nonmagnetic, unless an additional field is applied. [5] Nanomaterials may transport huge dosages of medicines to obtain great localized accumulation, preventing cytotoxic and other undesirable side symptoms occurring due to excessive dosing frequency in other regions of the body. In situ investigations showed that real clinical studies are a difficult job due to length management, durability, cytocompatibility, and adhesive coating for drug action as well as other physiologic characteristics. [3,6,7] The details of possible uses of magnetic nanoparticles (MNPs) in biomedical applications are given in Figure 2.The aim of creating or even strengthening administration methods is to deliver medicines to specific areas of the patient's system via a channel that can regulate the therapeutic distribution in terms of a physiologic or biochemical stimulus. Synthetic polymer-based microcapsules, microemulsions, and micelles are reported to be efficient in improving drug selectivity, reducing therapeutic toxicity, enhancing clinical oral bioavailability, and safety of medical products against biological degeneration. [15,16] Magnetically guided drug transportation is a technique in which magnetic pharmaceutical transporters in organisms are controlled by applied magnetic forces to deliver drugs to the desired location. Different magnetic drug delivery systems (MDDSs) are developed to treat a variety of illnesses, particularly cancer and neurological disorders. However, a unique magnetic setup is required in each application for an effective magnetically guided drug aiming to direct the drug-carrying nanocarriers to the intended area. The current and future perspectives of MDDS are investigated in this study by considering their biological functions, deliverable efficiency, complexity, and the nature of the externally applie...

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“…The applications of iron particles, with various sizes, compositions, and shapes, in the biomedical fields have attracted worldwide attention during the past few years . Nonfunctionalized iron particles only have limited applications.…”

Section: Introductionmentioning

confidence: 99%

“…The surface functionalized iron particles with thin organic layers are commercially available, such as Feridex (dextran associated iron oxide) for contrast enhanced MRI, and are carboxylic acid functionalized for bio‐molecule separations . For hyperthermia applications, the heat generated from the iron particles by magnetic hysteresis effects result from on‐off switching of the magnetic field . Hence, high magnetic saturation properties of the iron particles must be maintained if the particles are subjected to surface coating.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of surface‐grafted poly(N‐isopropylacrylamide) and poly(carboxylic acid)—Iron particles via atom transfer radical polymerization for biomedical applications

Sutrisno

Fuchs

Evrensel

2013

J of Applied Polymer Sci

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This research relates to the preparation and characterization of surface grafted poly(N-isopropylacrylamide) and poly(carboxylic acid)–micron-size iron particles via atom transfer radical polymerization (ATRP). The surface grafted polymers–iron particles result in multifunctional materials which can be used in biomedical applications. The functionalities consist of cell targeting, imaging, drug delivery, and immunological response. The multifunctional materials are synthesized in two steps. First, surface grafting is used to place polymer molecules on the iron particles surface. The second step, is conjugation of the bio-molecules onto the polymer backbone. Fourier transform infrared (FTIR) spectroscopy and scanning electron microscopy were used to confirm the presence of polymers on the iron particles. The thickness of the grafted polymers and glass transition temperature of the surface grafted polymers were determined by transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). The covalent bond between grafted polymers and iron particles caused higher glass transition temperature as compared with non-grafted polymers. The ability to target the bio-molecule and provide fluorescent imaging was simulated by conjugation of rat immunoglobulin and fluorescein isothiocyanate (FITC) labeled anti-rat. The fluorescence intensity was determined using flow cytometry and conjugated IgG-FITC anti-rat on iron particles which was imaged using a fluorescence microscopy.

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Experimental examination of a targeted hyperthermia system using inductively heated ferromagnetic microspheres in rabbit kidney

Cited by 25 publications

References 18 publications

Magnetic Nanoparticles for Cancer Therapy

Magnetic Nanoparticles for Cancer Therapy

Multifunctional Magnetic Nanomedicine Drug Delivery and Imaging‐Based Diagnostic Systems

Synthesis and characterization of surface‐grafted poly(N‐isopropylacrylamide) and poly(carboxylic acid)—Iron particles via atom transfer radical polymerization for biomedical applications

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