Experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model

Moulia, Catherine; Brun, Nathalie; Dallas, John F.; Orth, Annie; Renaud, François

doi:10.1017/s0031182000067135

Cited by 76 publications

(76 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The second possible factor is the vague reproductive barrier among the current subspecies. In mice, despite capable hybridization in captivity, the reproductive barrier among subspecies is documented well in the hybrid zone studies (reviewed in Sage et al, 1993), which may be attributed to the potential fitness reduction of the hybrids such as the increased loads of intestinal parasites (Moulia et al. 1993;Sage et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

et al. 2008

View full text Add to dashboard Cite

Patterns of genetic variation provide insight into the evolutionary history of a species. Mouse (Mus musculus) is a good model for this purpose. Here we present the analysis of genealogies of the 21 nuclear loci and one mitochondrial DNA region in M. musculus based on our nucleotide sequences of nine inbred strains from three M. musculus subspecies (musculus, domesticus, and castaneus) and one M. spicilegus strain as an outgroup. The mitochondrial DNA gene genealogy of those strains confirmed the introgression pattern of one musculus strain. When all the nuclear DNA data were concatenated to produce a phylogenetic tree of nine strains, musculus and domesticus strains formed monophyletic clusters with each other, while the two castaneus strains were paraphyletic. When each DNA region was treated independently, the phylogenetic networks revealed an unnegligibly high level of subspecies admixture and the mosaic nature of their genome. Estimation of ancestral and derived population sizes and migration rates suggests the effects of ancestral polymorphism and gene flow on the pattern of genetic variation of the current subspecies. Gene genealogies of Fut4 and Dfy loci also suggested existence of the gene flow between M. musculus and M. spicilegus or other distant species.

show abstract

Section: Discussionmentioning

confidence: 99%

Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

et al. 2008

View full text Add to dashboard Cite

show abstract

“…For example, in the hybrid zone of the two mouse subspecies, Mus musculus musculus and M. musculus domesticus, mice with hybrid genotypes harbor more helminth parasites than mice of the two parental taxa [189]. However, the F1 from these subspecies has higher resistance to parasites than the parental mice [190].…”

Section: Inbreeding and Outbreeding In Population Strategies Of Defenmentioning

confidence: 99%

The Role of the Immune System in Behavioral Strategies of Reproduction

Мошкин

Gerlinskaya

Evsikov

2000

Journal of Reproduction and Development

View full text Add to dashboard Cite

Abstract. Since both reproduction and immunocompetence are costly, the negative reciprocal relationships between these functions were found in many species. Due to reproductive immunosuppression, some fraction of seasonally breeding populations of small mammals reproduces in the first breeding season, while others reproduce in the next one. Elevation of breeding efforts under the increased risk of mortality and the reproductive delay until recovery are the polar variants of mating behavior of parasitized individuals. However the parasite-induced changes of odor, visual or acoustic signals limit the mating success of the infected hosts. The direct influence of the immune system, regularly activated by infections, to chemicals signals can be answer to the question: why these signals are honest? Decrease of a strange infection risk by kin breeding can be a satisfactory strategy of an isolated population. Nevertheless, many species follow the inbreeding avoidance strategy, where the major histocompatibility complex (MHC) genes play key role in kin recognition. The advantage of MHC heterozygosity was found at the all steps of the breeding cycle; including mating choice, fertilization, pre-and postnatal development. So, the relationships between immune system and neuroendocrine regulation of behavior give proximate explanations of the evolutionary stable strategies of breeding behavior.

show abstract

“…in a classic laboratory experiment by Park 1948). Second, to examine if over-infection of one taxon as observed in the field has a genetic background, we tested whether the same infection pattern was seen under controlled laboratory conditions where other environmental forces were excluded or were kept constant (as in Moulia et al 1993).…”

Section: Introductionmentioning

confidence: 99%

The coexistence of hybrid and parentalDaphnia: the role of parasites

et al. 2006

View full text Add to dashboard Cite

Parasite driven time-lagged negative frequency-dependent selection of hosts has been studied in natural populations by following changes in host genotype frequencies over time. However, such dynamics have not been considered at higher taxonomic levels, for example, between parental species and their hybrids. In a field study on a Daphnia hybrid system, we observed that one Daphnia taxon first was relatively underinfected, but became over-infected after a strong increase in frequency. This finding is consistent with the idea of parasite evolution towards the most frequent host taxon. In two experiments, we investigated whether the assumptions made by a model of negative frequency-dependent selection apply to our host taxa system. First, we showed that the parasite can change the outcome of taxa competition and secondly, we confirmed that the over-infection of one host taxon observed in the field has a genetic basis. Our results indicate that the incorporation of host-parasite interactions at the species level may allow us to gain a more complete picture of forces driving dynamic taxa coexistence in Daphnia hybrid systems. More generally, we suggest that if hybrids coexist in sympatry with parental taxa, the infection patterns as observed under natural conditions may be rather temporal and unstable.

show abstract

Experimental evidence of genetic determinism in high susceptibility to intestinal pinworm infection in mice: a hybrid zone model

Cited by 76 publications

References 29 publications

Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies

The Role of the Immune System in Behavioral Strategies of Reproduction

The coexistence of hybrid and parentalDaphnia: the role of parasites

Contact Info

Product

Resources

About