Experimental evaluation of theoretical contact forces in the cat patellofemoral joint

Hasler, E.M.; Herzog, Walter; Ronsky, Janet L.

doi:10.1016/0021-9290(96)00016-4

Cited by 9 publications

(4 citation statements)

References 18 publications

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“…Elaborate studies in larger animal models confirmed these findings, even though with generally lower joint loading in quadrupeds. Stress loads of 1.5-3.5 BW patellofemoral were described in cats 33 and 2.1 BW tibiofemoral in the sheep model. 34 Although no data are available in the minipig model, we consider joint load in both locations as similar.…”

Section: Discussionmentioning

confidence: 99%

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

et al. 2009

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Various animal models for experimental osteochondral defect healing have been used in orthopaedic research. Two main defect locations were chosen: the patellar groove or the central part of the medial femoral condyles (MFC). To date, it is not clear whether both locations display similar patterns in critical size osteochondral defect healing. We retrospectively analysed both locations in our minipig model hypothesizing that they show similar healing pattern. Thirty-five defects were analysed after three or 12 months. Osteochondral defects were 10 mm deep and 6.3 mm (MFC, n ¼ 19) in diameter or 8 mm and 5.4 mm, respectively (trochlear groove [TG], n ¼ 16). Semi-quantitative histological scoring and histomorphological evaluation were carried out. Both defect locations showed fillings of fibrous and fibrocartilage-like repair tissue. The osseous defect was closed by endochondral bone formation in the MFC. Semi-quantitative scoring did not show differences, whereas qualitative histomorphological analysis more frequently showed cartilaginous repair tissue in MFC defects. There was more frequent subchondral bone cyst formation in MFC location (P ¼ 0.05), TG defects resulted in lower postoperative pain. Both defect localizations are suitable for studies on osteochondral healing. Since regenerating with less hyaline-like repair tissue and less subchondral cyst formation, TG is more favourable for experimental osteochondral defect healing in this model.

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Section: Discussionmentioning

confidence: 99%

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

et al. 2009

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“…6;Hasler et al 1996). Similarly, the corresponding joint pressures decreased because of the reduced muscle forces and altered gait kinematics.…”

Section: Hindlimb and Joint Mechanics In The Acl-transected Catmentioning

confidence: 91%

Considerations on Joint and Articular Cartilage Mechanics

Herzog

Federico

2006

Biomech Model Mechanobiol

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When studying joint degeneration leading to osteoarthritis (OA), it seems imperative that local joint tissue loading is known during normal everyday movement and that the adaptive/degenerative effects of this loading are quantified systematically. Philosophically, we believe the best way to approach this problem is by studying joint degeneration and osteoarthritis in long-term experimental models and by representing diarthrodial joints and the associated tissues with accurate, geometric and structural, theoretical models. Here, we present selected examples of our work representing this approach. Experimentally, we demonstrate that the local loading of joints changes continuously in experimental models of OA, not only because of the changing external and internal loading, but also because of the continuous alterations in joint contact geometry and tissue mechanical properties. Furthermore, we show that single bouts of joint loading affect gene expression, and that gene expression, as well as subsequent joint degeneration is site-specific. In fact, opposing articular surfaces that are exposed to the same loading may degenerate at completely different rates. Finally, we propose a series of theoretical models of articular cartilage and contact mechanics, demonstrating that many of the anisotropic and inhomogeneous properties can be explained by structural elements and their orientation and volumetric concentration across the tissue.

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“…Average contact pressures on the femoral condyle were estimated by calculating the joint contact forces from the knee extensor torques (Hasler et al, 1996) and by dividing the contact forces by the measured tibio-femoral contact areas obtained using two-photon microscopy and post-sacrifice morphometric measurements.…”

Section: Experimental Setup and Controlled Muscle Force Applicationmentioning

confidence: 99%

A novel method for determining articular cartilage chondrocyte mechanics in vivo

Abusara

Seerattan

Leumann

et al. 2011

Journal of Biomechanics

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Experimental evaluation of theoretical contact forces in the cat patellofemoral joint

Cited by 9 publications

References 18 publications

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

The effect of defect localization on spontaneous repair of osteochondral defects in a Göttingen minipig model: a retrospective analysis of the medial patellar groove versus the medial femoral condyle

Considerations on Joint and Articular Cartilage Mechanics

A novel method for determining articular cartilage chondrocyte mechanics in vivo

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